Impact of COVID-19 national lockdown on asthma exacerbations: interrupted time-series analysis of English primary care dataAsthma Published on 2021-09-292022-10-28 Journal: Thorax [Category] COVID-19, SARS, [키워드] age Algorithm all age groups Analysis approach Asthma asthma epidemiology both sexes Cohort conducted Corticosteroid Course COVID-19 database defined England English Evidence Exacerbation healthcare hospital Impact lockdown National Optimum pandemic Patient patients primary care recorded reduction reduction in reductions in Region required Result Sex statistically significant reduction stratified [DOI] 10.1136/thoraxjnl-2020-216512 PMC 바로가기 [Article Type] Asthma
Assessment of an intervention to optimise antenatal management of women admitted with preterm labour and intact membranes using amniocentesis-based predictive risk models: study protocol for a randomised controlled trial (OPTIM-PTL Study)양수천자 기반 예측 위험 모델을 사용하여 조산 및 온전한 막으로 입원한 여성의 산전 관리를 최적화하기 위한 중재 평가: 무작위 대조 시험을 위한 연구 프로토콜(OPTIM-PTL 연구)Article Published on 2021-09-282022-09-11 Journal: BMJ Open [Category] SARS, 임상, [키워드] 24 hour 24 hours added age All participant All participants Amniocentesis amniotic Amniotic cavity Analysis Antenatal Antibiotic therapy Antibiotics approval approved assessment authority Care chorioamnionitis clinical clinical trial conducted control group Corticosteroid Corticosteroids Cost analysis database Device doses doses of corticosteroids dropout rate drug eligible patient Ethics ethics committee EudraCT European European Union Drug Regulating Authorities Clinical Trials database evaluated fetal fetal medicine finding gestational age high risk highest hospital discharge Hospital stay identification identification number institutional protocols Intervention intervention arm Invasion majority management maternal medicine Medical devices medication Medicine Medicines membrane microbial multicentre observé Occurrence overtreatment peer-reviewed power power of 80% Predictive Pregnancy Primary outcome randomisation randomised randomised controlled trial receiving reducing reduction reduction in Registered Regulating required risk secondary outcome Secondary outcomes Spanish stratified Study protocol Trial two-sided type I type I error Ultrasonography union while women written Informed Consent [DOI] 10.1136/bmjopen-2021-054711 PMC 바로가기 [Article Type] Article
Comparison of the impact of chronic corticosteroid therapy on critical care outcomes of COVID-19 patients with and without history of chronic liver diseaseArticle Published on 2021-09-282022-10-04 Journal: Scientific Reports [Category] 임상, 치료법, [키워드] 28-day mortality Analysis chronic liver disease CLD comorbid condition condition conducted Corticosteroid corticosteroid therapy COVID-19 COVID-19 hospitalization COVID-19 pandemic COVID-19 patient COVID-19 severity Critical care daily dose demonstrated dose group Hospital stay Hospitalization Hospitalized ICU ICU admission inclusion criteria information liver Mortality no difference outcome Outcomes research Patient patients with COVID-19 retrospective risk factor Risk factors secondary seeking statistically significant difference viral infection with COVID-19 [DOI] 10.1038/s41598-021-98778-z PMC 바로가기 [Article Type] Article
Neuromyelitis optica spectrum disorder with active replication of hepatitis B virus and seropositive anti-aquaporin-4 antibody A case reportArticle Published on 2021-09-242023-06-03 Journal: Medicine [Category] B형 간염, [키워드] aquaporin-4 Corticosteroid HBV Liver function Neuromyelitis optica spectrum disorder [DOI] 10.1097/MD.0000000000027207 PMC 바로가기
Prompt Reduction in CRP, IL-6, IFN-γ, IP-10, and MCP-1 and a Relatively Low Basal Ratio of Ferritin/CRP Is Possibly Associated With the Efficacy of Tocilizumab Monotherapy in Severely to Critically Ill Patients With COVID-19Medicine Published on 2021-09-232022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] anti-IL-6 receptor antibody basal chemokine Clinical characteristics Clinical deterioration Combination combination therapy Corticosteroid COVID-19 Critically ill Critically ill patient CRP cytokine Cytokine storm Dexamethasone Effect evaluated exhibited expression healthy controls humanized IFN-γ IgG IgG antibody IL-6 Ill increase in indicate Inflammatory inhibit inhibited IP-10 management MCP-1 mechanical ventilation Meta-analysis Methylprednisolone monotherapy multiplex numbers of patients observational study outcomes oxygen supply Patient patients treated patients with COVID-19 Pneumonia Ratio RCT reduction in remained required respond Retrospective study serum severe COVID-19 significant increase significantly higher systematic review Tocilizumab tocilizumab administration treat Treatment virus with COVID-19 worsening [DOI] 10.3389/fmed.2021.734838 PMC 바로가기 [Article Type] Medicine
Case Report: Successful Treatment of Five Critically Ill Coronavirus Disease 2019 Patients Using Combination Therapy With Etoposide and CorticosteroidsMedicine Published on 2021-09-232022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] activated Activation acute respiratory distress (ARDS) age anti-inflammatory agents Antiviral ARDS Case series characterized clinical trial combination therapy contribute coronavirus disease Corticosteroid Corticosteroids Course COVID-19 COVID-19-associated ARDS distress drugs effective Efficacy and safety etoposide evaluate Fever FIVE hospitalized patient hyperinflammation Ill induce Infection Inflammation Inflammatory inflammatory mediator Invasive mechanical ventilation Japan lung Macrophage marker monocyte Mortality Multiple myeloma Patient patients reflected reported required SARS-CoV-2 second dose severe adverse event Steroids syndrome therapeutic strategy Therapies tissue injury treated treating COVID-19 patient Treatment underlying diseases [DOI] 10.3389/fmed.2021.718641 PMC 바로가기 [Article Type] Medicine
Effects of Short-Term Corticosteroid Use on Reactogenicity and Immunogenicity of the First Dose of ChAdOx1 nCoV-19 Vaccine단기 코르티코스테로이드 사용이 ChAdOx1 nCoV-19 백신의 첫 번째 용량의 반응성 및 면역원성에 미치는 영향Comparative Study Published on 2021-09-222022-09-12 Journal: Frontiers in Immunology [Category] SARS, 진단, [키워드] anti-SARS-CoV-2 antibody BNT BNT162b2 Cellular immune response ChAdOx1 nCoV-19 Concentration Corticosteroid COVID-19 dose Effect electrochemiluminescence immunoassay evaluated first dose groups HCW HCWs healthcare worker IFN-γ immunogenicity interferon gamma interquartile range IQR low-dose corticosteroid median prednisolone equivalent Quantitative reactogenicity recruited reduce robust significantly significantly higher Spike protein statistical significance steroid total score vaccination Vaccine was measured [DOI] 10.3389/fimmu.2021.744206 PMC 바로가기 [Article Type] Comparative Study
Clinical outcomes in patients co-infected with COVID-19 and Staphylococcus aureus : a scoping reviewResearch Published on 2021-09-212022-10-28 Journal: BMC Infectious Diseases [Category] COVID-19, SARS, [키워드] age Analysis Antibiotics article articles Aside assessment Bacteremia bacterial co-infection bacterial pathogen cause CINAHL clinical Clinical outcome clinical outcomes Co-infection Combination conducted Corticosteroid COVID-19 COVID-19 vaccination critical appraisal database death discharge eligible Endocarditis English Evidence Final hospital Hospital admission Hospitalization ICU admission Infection Intervention intubation Joanna majority mechanical ventilation mortality rate outcome OVID pandemic Pandemics Pathogens Patient patient mortality patients physician provided Quality reducing reported Result risk Secondary bacterial infections Sex significantly spread of COVID-19 staphylococcal Staphylococcus aureus strain supplementary material Symptoms the WHO Treatment venous catheter were infected with COVID-19 [DOI] 10.1186/s12879-021-06616-4 PMC 바로가기 [Article Type] Research
Risk factors for invasive aspergillosis in ICU patients with COVID-19: current insights and new key elementsReview Published on 2021-09-152022-10-28 Journal: Annals of Intensive Care [Category] COVID-19, [키워드] acute respiratory distress syndrome Admission Antibiotics article association CAPA Characteristics chronic condition Chronic kidney disease Comorbidities concerning conditions Corticosteroid Corticosteroids Course COVID COVID-19 COVID-19-associated pulmonary aspergillosis Critically ill patient diabetes Diagnosis diagnostic disease element environmental factors epidemiological evaluate Factor Factors feature hospital Host ICU ICU patient Immunomodulatory agents influenza infection intensive care intensive care unit invasive Invasive pulmonary aspergillosis IPA Isolation Liver cirrhosis management mechanical ventilation Non-invasive respiratory support Obstructive pandemic potential risk Prolonged Prospective Study pulmonary disease reported respiratory diseases Reviewing risk factor Risk factors SARS-CoV-2 SARS-CoV2 infection severe immunosuppression shifting Spread Surveillance Therapeutic approach Therapies therapy treat Treatment Ventilation [DOI] 10.1186/s13613-021-00923-4 PMC 바로가기 [Article Type] Review
The efficacy of corticosteroids therapy in patients with moderate to severe SARS-CoV-2 infection: a multicenter, randomized, open-label trial중등도 내지 중증 SARS-COV-2 감염 환자에서 코르티코 스테로이드 요법의 효능 : 다기관, 무작위 화, 오픈 라벨 시험Randomized Controlled Trial Published on 2021-09-152022-08-13 Journal: Respiratory Research [Category] 임상, 치료제, [키워드] Admission Anti-inflammatory drugs assigned Azithromycin clinical recovery Corticosteroid Corticosteroids corticosteroids therapy deaths Diabetic diabetic patient diabetic patients dosage Effectiveness Efficacy group Hospital stay Hydroxychloroquine ICU admission in-hospital mortality intensive care intensive care unit intubation ITT Lopinavir Lopinavir/ritonavir LOS low dose Low dose prednisolone management mechanical ventilation mITT mITT and PP populations mITT population moderate to severe modified intention-to-treat Modified ITT multicenter naproxen no significant difference no significant differences number of deaths Open-label open-label trial outcome Patient patients patients treated patients with moderate per-protocol per-protocol population per-protocol populations performed Population PP population Prednisolone Primary outcome Randomized Randomly receive receiving regimen Result Ritonavir secondary Secondary outcomes severe COVID-19 severe SARS-CoV-2 significantly lower steroid therapeutic treated treatment regimen treatment regimens Trial [DOI] 10.1186/s12931-021-01833-6 PMC 바로가기 [Article Type] Randomized Controlled Trial