Biological evaluation of a mechanical ventilator that operates by controlling an automated manual resuscitator. A descriptive study in swineResearch Article Published on 2022-03-032022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, SARS, [키워드] addition alteration anaesthesia Analysis automated Biological blood biochemistry Brain carbonate Clinical studies condition detect eight electrocardiogram evaluate Evidence health system healthy histopathological in vivo kidney Lactate liver lung mechanical ventilation mechanical ventilator organ outbreak Oxygenation PaO parameter pathological finding performed physiological level physiological response preclinical data produced reported Support tissue tissue damage ventilatory parameters Volume [DOI] 10.1371/journal.pone.0264774 PMC 바로가기 [Article Type] Research Article
Mental health and self-determination profiles of the diverse population of medical students in Malaysia during the COVID-19 pandemicResearch Published on 2022-03-032022-10-28 Journal: BMC Psychology [Category] COVID-19, MERS, SARS, [키워드] addition affected aligned ANOVA Autonomy change collected competence component contribute COVID-19 COVID-19 pandemic Diversity Effect eight emotional Evidence expression Factor feature Gender Health identify intrinsic Local Malaysia medical school mental health Modification modifications modify pandemic participant principal profile programming Quantitative reduced Relatedness reliability representing response Result Schools Self-determination supplementary material undergraduate medical education unique was related Well-being were assessed [DOI] 10.1186/s40359-022-00759-y PMC 바로가기 [Article Type] Research
Remote management of osteoporosis in the first wave of the COVID-19 pandemicOriginal Article Published on 2022-03-022022-10-27 Journal: Archives of Osteoporosis [Category] COVID-19, [키워드] age Ancona approach center chronic disease clinic clinical condition Compliance conducted confirmed case coronavirus disease COVID-19 COVID-19 diagnosis COVID-19 mortality COVID-19 pandemic COVID-19 patient COVID-19 patients Critical deaths Deceased Denosumab diagnosed eight endocrinology evaluate fatality First wave Follow-up general condition hospital Hospitalization Italy less management medications metabolic metabolism National novel older patients Osteoporosis pandemic Patient patients Prevalence remote reported Result routine care SARS-CoV-2 SARS-COV-2 infection Support Symptom Telemedicine Treatment Umberto Vitamin D Vitamin D supplementation [DOI] 10.1007/s11657-022-01069-x PMC 바로가기 [Article Type] Original Article
Remote management of osteoporosis in the first wave of the COVID-19 pandemicOriginal Article Published on 2022-03-022022-10-27 Journal: Archives of Osteoporosis [Category] Coronavirus, COVID-19, MERS, SARS, [키워드] age Ancona approach center chronic disease clinic clinical condition Compliance conducted confirmed case coronavirus disease COVID-19 COVID-19 diagnosis COVID-19 mortality COVID-19 pandemic COVID-19 patient COVID-19 patients Critical deaths Deceased Denosumab diagnosed eight endocrinology evaluate fatality First wave Follow-up general condition hospital Hospitalization Italy less management medications metabolic metabolism National novel older patients Osteoporosis pandemic Patient patients Prevalence remote reported Result routine care SARS-CoV-2 SARS-COV-2 infection Support Symptom Telemedicine Treatment Umberto Vitamin D Vitamin D supplementation [DOI] 10.1007/s11657-022-01069-x PMC 바로가기 [Article Type] Original Article
Effect of not vortexing nasopharyngeal and throat swabs on SARS-CoV-2 nucleic acid detection: A pilot studySARS-CoV-2 핵산 검출에 대한 비인두 및 인후 면봉 검사의 효과: 파일럿 연구Article Published on 2022-03-012022-09-11 Journal: Journal of virological methods [Category] SARS, 치료기술, [키워드] Analysis appear assays automated cellular cellular material Ct values cycle threshold Effect eight IMPROVE Laboratory nasopharyngeal nucleic acid nucleic acid amplification nucleic acid tests PCR pilot study positive processing Qualitative reduction in respiratory virus Sample Sample processing SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 nucleic acid SARS-CoV-2 RNA SARS-CoV-2 testing semi-quantitative sensitivity submitted Support Swab swab sample swab samples swabs tested throat swab transport medium Viral transport medium Vortex Vortex. Vortexing VTM while [DOI] 10.1016/j.jviromet.2022.114468 PMC 바로가기 [Article Type] Article
Study of Alteplase for Respiratory Failure in SARS-CoV-2 COVID-19: A Vanguard Multicenter, Rapidly Adaptive, Pragmatic, Randomized Controlled TrialClinical Trial Published on 2022-03-012022-10-05 Journal: Chest [Category] SARS, 임상, [키워드] activated alteplase ARDS baseline benefit bleeding event Brain Combination control group Controlled COVID-19 cross-sectional early administration eight Enrollment failure fibrinolysis Hemorrhagic IMPROVE Improvements improvements in oxygenation in-hospital mortality IQR maintain mechanism microthrombi Mortality neurologic observation occurred outcome Participants Patient patients Phase 1 Phase 2 phase 3 study Primary outcome pulmonary pulmonary failure Pulmonary function randomization Randomized receiving respiratory Respiratory failure Safe SARS-CoV-2 secondary severe COVID-19 significantly Standard-of-care statistically significant difference stroke therapeutic tissue plasminogen activator Tissue plasminogen activator (tPA) Treatment Vascular ventilator-free day VFD were excluded [DOI] 10.1016/j.chest.2021.09.024 PMC 바로가기 [Article Type] Clinical Trial
Discrepancy between frequent occurrence of COVID-19-like symptoms and low seroconversion rates among healthcare workersCOVID-19 유사 증상의 빈번한 발생과 의료 종사자 간의 낮은 혈청 전환율 간의 불일치Article Published on 2022-03-012022-09-11 Journal: Journal of medical virology [Category] MERS, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibodies antibody antibody status approved chemiluminescence cohort characteristics coronavirus COVID-19 cross-sectional cross-sectional study demonstrated detectable discrepant result discrepant results dysfunction eight except for First wave General practice Germany group healthcare worker IgG immunoassay Immunoglobulin Immunoglobulin G in vitro independent Infection infection rate initial screening laboratory-confirmed low seroconversion rate medical staff Microparticle neutralization neutralization test neutralizing capacity no significant difference no significant differences Occurrence pandemic participant positive Predictive Predictive value questionnaire Questionnaires respiratory resulting Sample SARS-CoV-2 screening test self-diagnosis Seroconversion seroconversion rate seroconversion rates seroconversion rates. specific antibodies Spike-specific antibody Symptom Symptoms taste dysfunction test results tested was performed [DOI] 10.1002/jmv.27385 PMC 바로가기 [Article Type] Article
Detection and Contact Tracing of COVID-19 in Indonesia through a Red Cross Community Based Surveillance SystemConference abstract Published on 2022-03-012022-10-05 Journal: International Journal of Infectious Diseases [Category] 치료기술, [키워드] 24 hours Active surveillance approach CBS Community complement component Contact Contact tracing COVID-19 Critical detect detection Diagnosis disease effective eight event feasible Follow-up visit Health health authorities healthcare facility Human identify individual Indonesia Infectious disease Local local response management many cases material Pandemics PCR positive positive preventive measure public health Red reported Result scaled supported Surveillance System threat tracing undergo Volunteer volunteers [DOI] 10.1016/j.ijid.2021.12.085 [Article Type] Conference abstract
A phase I, first-in-human, randomized dose-escalation study of anti-activated factor XII monoclonal antibody garadacimab항 활성화 인자 XII 단일 클론 항체 garadacimab의 I 상, 최초 인간, 무작위 용량 증량 연구Clinical Trial Published on 2022-03-012022-09-12 Journal: Clinical and translational science [Category] MERS, 임상, 진단, [키워드] activated activities Analysis antibodies blood sample clinical development Coagulation Cohort cohorts collected Contact coronavirus disease COVID-19 deaths demonstrated dose dose-dependent dose-dependent manner dose-escalation Effect eight Factor healthy healthy volunteers increase in increases in inhibit intravenous male monoclonal antibody MOST pathway Phase I Placebo plasma plasma concentration positive proinflammatory Prothrombin time prothrombotic Randomized reported single-center Support TEAE TEAEs tested Tolerability treatment-emergent adverse event Volunteer volunteers [DOI] 10.1111/cts.13180 PMC 바로가기 [Article Type] Clinical Trial
Jusanin, a New Flavonoid from Artemisia commutata with an In Silico Inhibitory Potential against the SARS-CoV-2 Main ProteaseArticle Published on 2022-03-012022-10-30 Journal: Molecules [Category] COVID-19, MERS, SARS, [키워드] Artemisia commutata addition ADMET applied being binding binding energy carried co-crystallized complex conducted Covid-19 main protease DFT eight enzyme flavonoid in silico indicated Jusanin Ligand M pro metabolite molecular molecular docking Molecular docking study molecular dynamic simulations Molecular dynamics simulation molecular similarity New new flavonoid NMR PDB Potential Proteins SARS-CoV-2 SARS-CoV-2 main protease Seven similarity the SARS-CoV-2 Toxicity [DOI] 10.3390/molecules27051636 PMC 바로가기 [Article Type] Article