Psychological distress among frontline workers during the COVID-19 pandemic: A mixed-methods studyResearch Article Published on 2021-08-052022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, SARS, [키워드] analysed Burnout connection COVID-19 COVID-19 pandemic distress element ENhance explained healthcare indicated mitigate novel Nurses Outbreaks participant Patient Perspective professional Psychological Psychological distress qualitative data Quantitative data reduce reduced repeated measures Result Satisfaction social environment Support survey thematic analysis unique variance virus with COVID-19 work-life balance [DOI] 10.1371/journal.pone.0255510 PMC 바로가기 [Article Type] Research Article
Dynamics of SARS-CoV-2 Spike Proteins in Cell Entry: Control Elements in the Amino-Terminal Domains세포 진입에서 SARS-CoV-2 스파이크 단백질의 역학: 아미노 말단 도메인의 제어 요소Research Article Published on 2021-08-032022-09-10 Journal: mBio [Category] MERS, SARS, 변종, [키워드] ACE2 receptors acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive amplify associations binding cell entry change changes in comparison Comparisons complex Control coronavirus coronavirus spike protein coronavirus spike proteins correlated domain driven by Dynamics effective element Extracellular greater inactivation Increased INDEL indels Infection initial membrane fusion murine NTD NTDs Quantitative RBD RBDs Receptor binding receptor-binding domains reduced Region respiratory sarbecovirus SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus spike Spike protein Spike proteins spikes stability Structure Substitution substitutions susceptible the receptor-binding domain the SARS-CoV-2 Trimers variant Variation variations virus virus entry virus infectivity virus receptors Virus-like particle virus-like particles [DOI] 10.1128/mBio.01590-21 PMC 바로가기 [Article Type] Research Article
Exploring the Druggability of Conserved RNA Regulatory Elements in the SARS‐CoV‐2 GenomeResearch Article Published on 2021-08-032022-10-28 Journal: Angewandte Chemie (International ed. in English) [Category] Coronavirus, SARS, [키워드] assays binding Compound conserved COVID19-NMR defined druggability effective element elements experiments fragment screening functional Genome group in vivo Ligand NMR NMR spectroscopy nuclear nucleotides performed positive Region Regulatory RNA RNA genome RNAs SARS-CoV-2 SARS‐CoV‐2 targets [DOI] 10.1002/anie.202103693 PMC 바로가기 [Article Type] Research Article
Development of a framework for the implementation of synchronous e-mental health: a protocol for a realist synthesis of systematic reviews동기 멘탈 건강의 구현을위한 프레임 워크 개발 : 체계적인 검토의 현실주의 합성을위한 프로토콜Study Protocol Published on 2021-08-032022-08-31 Journal: F1000Research [Category] Coronavirus, MERS, meta-analysis, SARS, [키워드] Analysis approach Care CINAHL communication conducted COVID-19 pandemic database determine develop development EBM element evaluated Evidence facilitator finding framework grounded theory Health Health care health problems hypothese hypotheses identify implementation include Inference information integration Internet-Based Intervention Interpretation Intervention limitation lower risk Mental Disorders mental health mental health care mental health problem mental health professional Meta-analysis Online Systems protocol PsycINFO Qualitative qualitative research Remote Consultation subject synchronous systematic review systematic reviews Systematic Reviews as Topic Telemedicine Web of Science [DOI] 10.12688/f1000research.27150.2 PMC 바로가기 [Article Type] Study Protocol
Green tea intake and its effect on laboratory parameters and disease symptoms in hospitalised patients with Covid 19: a structured protocol for a randomized controlled trialCovid 19 입원 환자의 실험실 매개변수 및 질병 증상에 대한 녹차 섭취 및 영향: 무작위 대조 시험을 위한 구조화된 프로토콜Letter Published on 2021-08-032022-09-10 Journal: Trials [Category] MERS, SARS, 임상, [키워드] 1:1 age All participants anticipated appearance assigned Blinding block block size block sizes blood count C-reactive protein Capsule categories CBC Chain Reaction change city clinical trial Coagulation Coagulopathy color company complete blood count computer-generated conducted control group COVID-19 COVID-19 diagnosis COVID-19 infection CRP CRP level CRP levels dinner disease symptom disease symptoms Disseminated intravascular coagulation dissemination division divisions double-blinded element erythrocyte sedimentation erythrocyte sedimentation rate ESR exploratory study green tea green tea supplement hospitalised patient inclusion criteria Infection Intervention intervention group intravascular coagulation Iran kidney Kidney failure laboratory parameter Laboratory parameters lactation Mild-to-moderate number objective outcome participant Patient patients with COVID-19 performed Placebo polymerase chain polymerase chain reaction Pregnancy protocol random randomised randomised controlled trial randomization Randomized controlled trial Randomly RCT real-time polymerase chain reaction recruit Registered required researcher RT-PCR Sample size sedimentation rate Sex shape status supplementary material total sample size Treatment treatment for COVID-19 twice a day Version was determined website [DOI] 10.1186/s13063-021-05462-8 PMC 바로가기 [Article Type] Letter
Induction of interferon response by high viral loads at early stage infection may protect against severe outcomes in COVID-19 patients감염 초기에 높은 바이러스 부하에 의한 인터페론 반응 유도는 COVID-19 환자의 심각한 결과로부터 보호할 수 있습니다Article Published on 2021-08-032022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 유전자 메커니즘, 치료기술, [키워드] Analysis antiviral response antiviral responses cellular Clinical outcome clinical outcomes Co-infection Cohort component correlated COVID-19 COVID-19 patient COVID-19 patients Critical defined disease severity Dysbiosis early phase early stage element Factor Gene Expression Gene expression analysis high viral load host responses include induction Infection infectious viruses interferon interferon response inverse correlation key factor limit of detection majority microflora Mild symptom mild symptoms nasopharyngeal outcome PROTECT question respiratory SARS-CoV-2 SARS-CoV-2 RNA Sequencing severe complications severe symptoms shown upper respiratory tract upregulation Viral Viral load viral loads viral pathogenesis viral strains viral titer Virological while [DOI] 10.1038/s41598-021-95197-y PMC 바로가기 [Article Type] Article
Traditional Chinese Medicine and Western Medicine Share Similar Philosophical Approaches to Fight COVID-19Commentary Published on 2021-08-012022-10-28 Journal: Aging and Disease [Category] COVID-19, [키워드] approach benefit Blood calcium Chinese cold-dampness COVID-19 diagnosing disease element ENhance etiological Evidence favorable effect FIVE immune function in viral infections Medicine other diseases pathogenesis of COVID-19 preventing disease reduce severity shown Spread TCM Traditional Traditional Chinese medicine treat Treatment viruses Vitamin D Vitamin D supplementation Western medicine with COVID-19 [DOI] 10.14336/AD.2021.0512 PMC 바로가기 [Article Type] Commentary
High triglyceride to HDL-cholesterol ratio as a biochemical marker of severe outcomes in COVID-19 patientsCOVID-19 환자의 심각한 결과를 나타내는 생화학적 지표로서 높은 중성지방 대 HDL-콜레스테롤 비율Observational Study Published on 2021-08-012022-09-11 Journal: Clinical nutrition ESPEN [Category] MERS, SARS, 바이오마커, 임상, [키워드] alteration applied association baseline biochemical biochemical marker Blood level blood levels can be used Cardiovascular events Chain Reaction cholesterol cohort study collected Comorbidities Comorbidity component coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 diagnosis COVID-19 patient COVID-19 patients critical care patient D-dimer Descriptive statistics determine diabetes Diabetes Mellitus dimer disease severity disorder dyslipidaemia element elements female ferritin FiO2 HDL HDL c high density lipoprotein Hospitalization Hospitalized hypertension identify Increases increases in indicated Inflammatory factor inflammatory factors inhibitor insulin insulin resistance Insulin sensitivity Invasive mechanical ventilation JAK1 Lactate lactate dehydrogenase LDH Linear regression analysis lipoprotein cholesterol Logistic regression logistic regression model male management Mechanical mechanical ventilation metabolic syndrome National Early Warning Score negative correlation NEWS Organ failure outcome oxygen oxygen support partial oxygen saturation Patient polymerase chain polymerase chain reaction predict predictor Prognosis qPCR qSOFA Quantitative quantitative polymerase chain reaction quick sequential organ failure assessment reduced regression analysis Regression model required ruxolitinib score severe complication severe complications shown subsequent syndrome Tg/HDLc ratio. Treatment Triglyceride type 2 diabete Type 2 diabetes mellitus variable [DOI] 10.1016/j.clnesp.2021.04.020 PMC 바로가기 [Article Type] Observational Study
The SARS-CoV-2 Programmed −1 Ribosomal Frameshifting Element Crystal Structure Solved to 2.09 Å Using Chaperone-Assisted RNA CrystallographyArticles Published on 2021-07-302022-10-28 Journal: ACS chemical biology [Category] COVID-19, SARS, [키워드] Affect alteration base pair chaperone conformation conserved contribute cryo-EM crystal Crystallography disrupt drug drug design drug target element Frame function genomes High-resolution junctions nonstructural protein observé polyprotein pp1a pp1ab produced promote provide RNA SARS-CoV-2 sequence stability stop codon Structure three-dimensional structure translation viral life cycle viral replication [DOI] 10.1021/acschembio.1c00324 PMC 바로가기 [Article Type] Articles
Drug Design Strategies for the Treatment of Viral Disease. Plant Phenolic Compounds and Their DerivativesPharmacology Published on 2021-07-302022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] Affect affecting Antiviral antiviral activity antiviral drugs antiviral property benefit biochemical cause cellular complexes Compound contribute coronavirus derivative drug drug design element Host host cells hydrolysis increase in infected cells inhibit Interaction M pro maturation mechanism of action membrane metal complexes pandemic penetration Phenolic compounds plant protease Protein RdRP receptors Replication Research RNA-dependent RNA polymerase SARS CoV-2 secretion selected shown significantly Spike protein Stage Strategy transfer Treatment Triglyceride turn viral disease viral life cycle virus [DOI] 10.3389/fphar.2021.709104 PMC 바로가기 [Article Type] Pharmacology