An evaluation of a FluoroSpot assay as a diagnostic tool to determine SARS-CoV-2 specific T cell responsesSARS-COV-2 특이 적 T 세포 반응을 결정하기위한 진단 도구로서 플루오 스팟 분석의 평가Research Article Published on 2021-09-302022-09-10 Journal: PLoS ONE [Category] SARS, 진단, 치료법, [키워드] addition Affect aligning Amino acid appear assays blood sample Blood samples calculated cellular Cellular immune response cellular immune responses cellular response Chain Reaction Cohort COVID-19 patients cross-reactive determine diagnostic diagnostic value dual endemic HCoVs evaluated HCoVs HCW healthcare worker Healthcare workers hospitalized COVID-19 patient house human coronavirus human coronaviruses IFN-γ IgG immune response immune responses individuals less nucleocapsid Numerous peptide peptide pool peptide pools polymerase chain polymerase chain reaction post infection reference standard Release repeated Research SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike sensitivity Seroconversion serological serological assays serology seronegative Specificities specificity T cell T cell response [DOI] 10.1371/journal.pone.0258041 PMC 바로가기 [Article Type] Research Article
Risk factors, predictions, and progression of acute kidney injury in hospitalized COVID-19 patients: An observational retrospective cohort studyObservational Study Published on 2021-09-292022-10-04 Journal: PLoS ONE [Category] SARS, 임상, [키워드] 95% CI Acute kidney injury addition Admission age AKI AKI patient analyzed Bahrain cardiac injury marker clinician Comorbidity complex conducted correlated covariate adjustment COVID-19 patient COVID-19 patients dead patient death develop diabete died Factors Follow-up force hospital Hospital admission hospitalized COVID-19 hospitalized COVID-19 patient hospitalized patients hypercoagulability hypertension incidence increased the risk Laboratory testing less medical record medications moderate mortality rate multivariate logistic regression objective Observational cohort study Occurrence Odds ratio on mechanical ventilation Patient patients with AKI poor prognosis positively correlated Prognosis progression regression analysis reported Result retrieved retrospective retrospective cohort study risk factor SARS-COV-2 infection serum albumin shown treated troponin with COVID-19 [DOI] 10.1371/journal.pone.0257253 PMC 바로가기 [Article Type] Observational Study
Is glucose-6-phosphatase dehydrogenase deficiency associated with severe outcomes in hospitalized COVID-19 patients?Article Published on 2021-09-282022-10-04 Journal: Scientific Reports [Category] SARS, 치료법, [키워드] 95% confidence interval age aggravate antioxidant association COVID-19 patients deficiency Epidemiology glucose-6-phosphate dehydrogenase deficiency Hospitalized hospitalized COVID-19 hospitalized COVID-19 patient Intervention intubation likelihood non-invasive ventilation not significantly different Occurrence outcome Outcomes research Patient presence of comorbidity Research Respiratory signs and symptoms Risk factors severe COVID-19 severity of COVID-19 suppress viral infection [DOI] 10.1038/s41598-021-98712-3 PMC 바로가기 [Article Type] Article
Role of fatty liver in coronavirus disease 2019 patients’ disease severity and hospitalization length: a case–control studyResearch Published on 2021-09-262022-10-31 Journal: European Journal of Medical Research [Category] COVID-19, [키워드] affected approach Chest chest CT-scan Complication control group coronavirus disease Coronavirus disease 2019 (COVID-19) COVID-19 COVID-19 pandemic COVID-19 patients determine develop disease severity Fatty liver Hospitalization Hospitalized hospitalized COVID-19 patient Hounsfield unit Illness severity liver Liver injury lobe lobes lung Non-COVID-19 patients pandemic Patient patients positive PCR test Prevalence prevalent Result Retrospective study role severe disease severity significantly higher significantly more statistical analysis Stay length the disease the SARS-CoV-2 [DOI] 10.1186/s40001-021-00590-y PMC 바로가기 [Article Type] Research
Outpatient and inpatient anticoagulation therapy and the risk for hospital admission and death among COVID-19 patientsResearch Paper Published on 2021-09-242022-10-04 Journal: EClinicalMedicine [Category] 유전자 메커니즘, [키워드] (n), number %, percentage ACEi, angiotensin-converting enzyme inhibitors age anticoagulation ARBs, angiotensin receptor blockers CI, confidence intervals CKD, chronic kidney disease clinics CO2, carbon dioxide COPD, Chronic obstructive pulmonary disease Coronavirus disease 2019 COVID-19 COVID-19 diagnosis COVID-19 patient COVID-19, Coronavirus disease 2019 D-dimer death deaths diagnosed with COVID-19 Diagnosis DIC, disseminated intravascular coagulation DOAC, direct oral anticoagulant EHR, electronic health records EMR, electronic medical records evaluated failure finding funding HCT, hematocrit HIT, heparin-induced thrombocytopenia hospital Hospital admission Hospitalization Hospitalized hospitalized COVID-19 patient HR, hazard ratio hypercoagulable increased mortality increased risk Inpatient investigated IPAC, inpatient anticoagulation therapy IRB, institutional review board Limited mg/dl, milligram per deciliter MI, prior myocardial infarction Mortality mortality risk multivariable analysis OPAC, outpatient persistent anticoagulation therapy Outpatient outpatients overall case-fatality rate Patient patients prospective cohort study RDW, red blood cell distribution width reduced risk reduction in risk RT-PCR, Reverse transcriptase-polymerase chain reaction SARS-COV-2, severe acute respiratory syndrome coronavirus-2 SBP-min, minimum systolic blood pressure SBP, systolic blood pressure SD, standard deviations SE, standard errors SpO2-min, minimum oxygen saturation T1DM, type 1 diabetes mellitus T2DM, type 2 diabetes mellitus the patient therapy treated USA VTE, venous thromboembolism was obtained WBC, White blood cell with COVID-19 [DOI] 10.1016/j.eclinm.2021.101139 PMC 바로가기 [Article Type] Research Paper
Endothelial Activation and Stress Index (EASIX) as an Early Predictor for Mortality and Overall Survival in Hematological and Non-Hematological Patients with COVID-19: Multicenter Cohort StudyArticle Published on 2021-09-242022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] Activation acute renal failure Admission Biomarker Cancer Cancer patients characterized Course COVID-19 COVID-19 diagnosis COVID-19 patient COVID-19 patients creatinine demonstrated disease EASIX endothelial Endothelial dysfunction Endothelium group hematological hematological cancer Hematological malignancy Hemodialysis high mortality rate hospitalized COVID-19 patient hospitalized patients in-hospital mortality index intensive care lactate dehydrogenase multiple organs Occurrence Patient patients patients with COVID-19 performed Platelet count prognostic Retrospective analysis risk Sepsis significantly Stress survival with COVID-19 [DOI] 10.3390/jcm10194373 PMC 바로가기 [Article Type] Article
Cytometric analysis of patients with COVID-19: what is changed in the second wave?Research Published on 2021-09-232022-10-30 Journal: Journal of Translational Medicine [Category] COVID-19, SARS, [키워드] activated Activation age Analysis analyzed changed Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Cytokine storm cytometric Cytometry Diagnosis enzyme-linked immunosorbent Europe expression flow cytometry Gender help Hospitalization Hospitalized hospitalized COVID-19 patient IL-6 level immune response interleukin-6 less lymphocyte lymphocyte subpopulation Lymphocytes Mild moderate modulate monoclonal antibody natural killer cell pandemic Patient patients reduction Result serum stages subpopulation subpopulations T helper T lymphocyte T regulatory cell targeted therapy therapy virus [DOI] 10.1186/s12967-021-03072-1 PMC 바로가기 [Article Type] Research
Increased sHLA-G Is Associated with Improved COVID-19 Outcome and Reduced Neutrophil Adhesion증가 된 SHLA-G는 개선 된 COVID-19 결과 및 호중구 접착 감소와 관련이 있습니다.Article Published on 2021-09-172022-08-31 Journal: Viruses [Category] SARS, 바이오마커, [키워드] activated Activation adhesion Admission Analysis Biomarker Blood CD160 changes in clinical condition clinical evolution Clinical improvement control patients controls COVID-19 COVID-19 patient COVID-19 patients E-selectin ELISA assay endothelial Endothelial cell endothelial cells Endothelium evaluated expression FGF2 HLA HLA-G hospitalized COVID-19 patient hospitalized COVID-19 patients human leukocyte antigen ICAM-1 Improved in vitro Increased infective Inflammatory Interaction inverse correlation involved leukocyte molecules neutrophil plasma Plasma levels plasma samples quantified Respiratory failure responses selectin serum significantly higher [DOI] 10.3390/v13091855 PMC 바로가기 [Article Type] Article
Continuous Remote Patient Monitoring Shows Early Cardiovascular Changes in COVID-19 PatientsArticle Published on 2021-09-172022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] Admission affected Analysis artificial intelligence Blood oxygen saturation body temperature Cardiopulmonary cardiopulmonary parameters cardiovascular change changes in collected conducted Continuous COVID-19 COVID-19 patient Deleterious Deterioration Diastolic blood pressure Early detection Effects Final FIVE high risk high-risk population hospitalized COVID-19 patient Isolation monitoring Observational cohort study parameter Patient remote Remote patient monitoring respiratory parameters respiratory rate retrospective show significant difference trajectory Vascular Vital vital signs were measured worse prognosis [DOI] 10.3390/jcm10184218 PMC 바로가기 [Article Type] Article
Comparison of systemic immune-inflammation index (SII), early warning score (ANDC) and prognostic nutritional index (PNI) in hospitalized patients with malignancy, and their influence on mortality from COVID-19Research Article Published on 2021-09-152022-10-30 Journal: Infectious Agents and Cancer [Category] COVID-19, [키워드] age ANDC both groups Comorbidity COVID-19 COVID-19 case COVID-19 pneumonia Deceased diagnosed with COVID-19 duration of hospitalization Early warning score evaluated had no Hospitalized hospitalized COVID-19 patient hospitalized patient In-hospital death independent Inflammation lymphocyte malignancies malignancy measure monocyte Mortality neutrophil nutritional status Patient patients with SARS-CoV-2 Platelet Pneumonia PNI predictive power prognostic propensity score matching Real-time PCR Result retrospective significantly significantly higher significantly lower SII statistically suggested survivor two groups [DOI] 10.1186/s13027-021-00400-4 PMC 바로가기 [Article Type] Research Article