innate immune response – Page 22 – Communicable Diseases Research

RIG-I-Like Receptor-Mediated Recognition of Viral Genomic RNA of Severe Acute Respiratory Syndrome Coronavirus-2 and Viral Escape From the Host Innate Immune Responses

중증 급성 호흡기 증후군 코로나바이러스-2의 바이러스 게놈 RNA의 RIG-I 유사 수용체 매개 인식 및 숙주 선천 면역 반응으로부터의 바이러스 탈출

Immunology

Published on 2021-06-252022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, 진단, 치료법,

Autophagy receptors as viral targets

Review Letter

Published on 2021-06-242022-10-31
Journal: Cellular & Molecular Biology Letters [Category] COVID-19,

[키워드] autophagic autophagy cargo component cytosol Degradation evade Infection innate immune response innate immune responses Interaction knowledge lysosome promote receptor receptors Replication Research selective shown target Vesicle viral infections viruses Xenophagy
[DOI] 10.1186/s11658-021-00272-x PMC 바로가기 [Article Type] Review Letter

Translational shutdown and evasion of the innate immune response by SARS-CoV-2 NSP14 protein

SARS-CoV-2 NSP14 단백질에 의한 타고난 면역 반응의 번역 차단 및 회피

423

Published on 2021-06-152022-09-10
Journal: Proceedings of the National Academy of Sciences of [Category] MERS, SARS, 유전자 메커니즘,

[키워드] active site active sites activities acute respiratory syndrome acute respiratory syndrome coronavirus addition Antiviral antiviral proteins antiviral response causative agent caused complex conserved coronavirus COVID-19 COVID-19 pandemic Critical demonstrated ENhance evade ExoN Exoribonuclease Health Health crisis Host host antiviral responses Host immune response host immune responses host protein human coronaviruses IFN-I IFN-I responses immune evasion immune responses Infection inhibit inhibition activity inhibitor inhibitory innate immune response Innate immunity interferon interferon-stimulated gene interferon-stimulated genes ISGs mechanism nsp14 overcome Pathogenesis pathogenesis of SARS-CoV-2 pathogenic virus pathogenic viruses Pathogens previous study Protein Proteins replicate required respiratory reveal SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Significance subversion synthesis the SARS-CoV-2 translation translation inhibition translational type I interferon Viral viral pathogens virus replication viruses
[DOI] 10.1073/pnas.2101161118 PMC 바로가기 [Article Type] 423

COVID-19: Lung-Centric Immunothrombosis

Cellular and Infection Microbiology

Published on 2021-06-112022-10-31
Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID-19, MERS, SARS,

Targeted Mitochondrial Therapy With Over-Expressed MAVS Protein From Mesenchymal Stem Cells: A New Therapeutic Approach for COVID-19

Cell and Developmental Biology

Published on 2021-06-112022-10-31
Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19,

[키워드] ACE2 addition affecting approach cause Cell cellular cellular immunity COVID-19 damaged cell damaged tissue disease Diseases element expression expression of SARS-CoV-2 healthy host cell IFN immune immune response Impaired IMPROVE induce Inflammation innate immune response innate immune responses innate immune system interferon Ligand MAVS mesenchymal stem cell Mitochondria mitochondrial mitochondrial antiviral-signaling protein MSC MSCs New outer membrane pathogenesis of COVID-19 Probability Protein pulmonary involvement reduce regenerative regulate Regulatory rejection Replication S protein SARS-CoV-2 STEM stem cell Stress Symptom the SARS-CoV-2 these cell tissue inflammation transferring Transport viable treatment viral spike protein virus
[DOI] 10.3389/fcell.2021.695362 PMC 바로가기 [Article Type] Cell and Developmental Biology

SARS-CoV-2 ORF8 Forms Intracellular Aggregates and Inhibits IFNγ-Induced Antiviral Gene Expression in Human Lung Epithelial Cells

Immunology

Published on 2021-06-092022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS,

[키워드] acute respiratory syndrome addition aggregate aggregation analyses Anti-viral Antiviral antiviral immunity antiviral molecule antiviral molecules association baseline bioinformatic analysis cause cell cycle progression cell proliferation cellular cellular distribution cellular processes characteristic coronavirus COVID-19 COVID-19 patient Culture cytosol DHX58 disease ectopic expression Effect epithelial examined expressed expressing expression facilitate form Frame Host Human human lung IFNβ IFNγ Immunofluorescent staining in silico independent Inflammation inhibit innate immune response interferon signaling Intracellular intrinsic lung lung epithelial lung epithelial cell Lung epithelial cells Lung injury lung tissue MX1 MX2 N-terminal not affect nuclear ORF8 pathogenic Protein Regulation residue SARS-CoV-2 SARS-CoV-2 accessory protein SARS-COV-2 infection suppressed Symptom unique viral infection ZBP1
[DOI] 10.3389/fimmu.2021.679482 PMC 바로가기 [Article Type] Immunology

PD-L1 Dysregulation in COVID-19 Patients

Immunology

Published on 2021-06-072022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS,

[키워드] Adaptive immune response ARDS biological sample blood sample caused CD4+ T cells clinical study consequence COVID-19 COVID-19 pandemic COVID-19 pathogenesis COVID-19 patient cultures dysregulated dysregulated immune response dysregulation effective epithelial cell Evidence healthy donors healthy individuals hospitalized COVID-19 patient Host immune response identify Immune cell immune checkpoint molecules in vitro Infection inhibitors innate immune response Ligand manifestation Manifestations model system modulation Monocytes Neutrophils Patient PD-L1 Prognosis prognostic prognostic biomarker reached RNA expression SARS-CoV-2 Serum level subset T cell therapeutic approaches tissue tissue biopsy upregulation variety
[DOI] 10.3389/fimmu.2021.695242 PMC 바로가기 [Article Type] Immunology

A unique view of SARS-CoV-2 through the lens of ORF8 protein

ORF8 단백질 렌즈를 통한 SARS-CoV-2의 독특한 시각

Article

Published on 2021-06-012022-09-11
Journal: Computers in biology and medicine [Category] SARS, 변종,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive amalgamation Amino acid Analysis antiviral response bat Characteristics Chemical coronavirus down-regulation Effect highlight histocompatibility Host host immunity hosts immune immune evasion immune responses innate immune response innate immune responses interferon Major major histocompatibility complex modulate Mutation Mutational hotspots ORF8 ORF8 evolution ORF8 protein ORF8 proteins pangolin pangolin-CoV performed Perspective phylogenetics phylogenies Physicochemical properties predicted Protein sample collection SARS-CoV-2 sequence similarity severe acute respiratory syndrome Coronavirus structural property unique variant
[DOI] 10.1016/j.compbiomed.2021.104380 PMC 바로가기 [Article Type] Article

Comprehensive Comparison of RNA-Seq Data of SARS-CoV-2, SARS-CoV and MERS-CoV Infections: Alternative Entry Routes and Innate Immune Responses

SARS-CoV-2, SARS-CoV 및 MERS-CoV 감염의 RNA-Seq 데이터 종합 비교: 대체 진입 경로 및 선천적 면역 반응

Immunology

Published on 2021-05-282022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘,

[키워드] A549 A549 cell A549 cells ACE2 Analysis Calu3 CaLu3 cells Cell cell entry cell type cells Comparative analysis complex Comprehensive COVID-19 patients dataset dose Evidence evidence of example expressing expression Factor human ACE2 IFNs immune responses imperative inefficient Infection Injury Innate innate immune response innate immune responses Innate immunity interferon interferons investigated ISGs mechanism MERS-CoV organs Pathogenesis pathogenesis of COVID-19 performed produced response Result RNA-seq data route SARS-CoV SARS-CoV-2 SARS-CoV-2 cell SARS-COV-2 infection second Support therapy These data TMPRSS2 transduced vector Viral viral entry virus virus entry route
[DOI] 10.3389/fimmu.2021.656433 PMC 바로가기 [Article Type] Immunology

Coronavirus Disease 2019 in Children

Pediatrics

Published on 2021-05-282022-10-31
Journal: Frontiers in Pediatrics [Category] COVID-19,

[키워드] Activation acute respiratory syndrome adolescents Adults affected Angiotensin-converting enzyme Antiviral Asymptomatic Care characterized chest imaging children Clinical course complex coronavirus coronavirus disease Course COVID-19 described Diagnosis drugs expression Factor healthcare worker Immunity implicated IMPROVE incidence information innate immune response lower airways manifestation mechanism of action Mild mild respiratory moderate morbidity MOST much lower Novel coronavirus occurred outbreak pandemic Pathogenesis patients pediatric positive receptor reduced respiratory viral infections SARS-CoV-2 SARS-COV-2 infection Spread subsequent suggested Symptom tested therapy thought Treatment Trial upper airway virus while Wuhan
[DOI] 10.3389/fped.2021.668484 PMC 바로가기 [Article Type] Pediatrics