Allocation of the “Already” Limited Medical Resources Amid the COVID-19 Pandemic, an Iterative Ethical Encounter Including Suggested Solutions From a Real Life EncounterMedicine Published on 2021-01-142022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] adhere Algorithm allocation automated cause challenges clinics country COVID-19 develop disease encounter ENhance Health healthcare Healthcare provider healthcare worker help ICU implementation Implementing include Including intensive care knowledge lack life Limited low-income countries Measures Migration overcome Patient precluded protocols remote monitoring resource resources solution Solutions Telemedicine the WHO unique [DOI] 10.3389/fmed.2020.616277 PMC 바로가기 [Article Type] Medicine
Deep Learning applications for COVID-19Survey Paper Published on 2021-01-112022-10-30 Journal: Journal of Big Data [Category] COVID-19, [키워드] accelerate Answering computer computer vision COVID-19 COVID-19 pandemic COVID-19 research deep Deep Learning applications detection drug Epidemiology example Forecasting generalization help Image include intelligence interpretability language learning life Life Sciences limitation Limited literature review misinformation natural natural language processing prediction privacy processing provide Public repurposing Research Retrieval robotics Structure vision [DOI] 10.1186/s40537-020-00392-9 PMC 바로가기 [Article Type] Survey Paper
CT radiomics facilitates more accurate diagnosis of COVID-19 pneumonia: compared with CO-RADSCT radiomics는 CO-RADS와 비교하여 COVID-19 폐렴의 더 정확한 진단을 용이하게 합니다.Comparative Study Published on 2021-01-072022-09-10 Journal: Journal of Translational Medicine [Category] 진단, 치료기술, [키워드] an area Analysis AUC build calibration curve Chest CT Chest CT image Chest CT images clinical clinical utility clinical variable Cohort Computed tomography COVID-19 COVID-19 pneumonia dataset decision curve analysis develop diagnosing diagnosis of COVID-19 diagnostic enrolled facilitate feature laboratory-confirmed Limited machine learning Non-COVID-19 operator other viral pneumonia Patient performed Pneumonia radiologist Radiomics receiver operating characteristics Result ROC selected Sensitivity and specificity training dataset validation cohort Viral Viral pneumonia [DOI] 10.1186/s12967-020-02692-3 PMC 바로가기 [Article Type] Comparative Study
Population-Specific ACE2 Single-Nucleotide Polymorphisms Have Limited Impact on SARS-CoV-2 Infectivity In Vitro인구 특이적 ACE2 단일 뉴클레오티드 다형성은 시험관 내 SARS-CoV-2 감염성에 제한적인 영향을 미칩니다Communication Published on 2021-01-062022-09-10 Journal: Viruses [Category] 유전자 메커니즘, [키워드] ACE2 ACE2 expression acute respiratory syndrome acute respiratory syndrome coronavirus Affect Analysis analyzed angiotensin angiotensin-converting enzyme 2 causative agent cell entry coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Efficiency eight enzyme except for host gene host genes human populations Impact in vitro indicated Infectivity Interaction Limited molecular dynamics Molecular dynamics simulation molecular dynamics simulations Mutation nonsense mutation performed polymorphism Population receptor Receptor binding reduced respiratory responsible SARS-2-S SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein selected severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severity single-nucleotide Single-nucleotide polymorphisms SNP SNPs Spike protein susceptibility the SARS-CoV-2 validation study Viral viral cell viral cell entry [DOI] 10.3390/v13010067 PMC 바로가기 [Article Type] Communication
Immunogenicity of Multiple Doses of pDNA Vaccines against SARS-CoV-2Article Published on 2021-01-062022-10-28 Journal: Pharmaceuticals [Category] COVID-19, [키워드] Activation acute respiratory syndrome antibody Antibody Response binding candidate cellular immune responses comparable coronavirus coronavirus disease COVID-19 COVID-19 vaccine death dose doses effective elicit full-length S globular head highest immune responses Immunity immunogenicity induce interferon Limited long-lasting magnitude marker mice Multiple natural infection Neutralizing antibodies Neutralizing antibody response neutralizing antibody responses Pandemics pDNA Plasmid preclinical data Reinfection required robust S-specific antibody SARS-CoV-2 SARS-CoV-2 vaccine Serum level Support translational Undetermined Vaccine viral spike virus Wuhan, China [DOI] 10.3390/ph14010039 PMC 바로가기 [Article Type] Article
Limited Specificity of Serologic Tests for SARS-CoV-2 Antibody Detection, BeninSARS-CoV-2 항체 검출을 위한 혈청학적 검사의 제한된 특이성, 베냉Dispatch Published on 2021-01-012022-09-10 Journal: Emerging Infectious Diseases [Category] MERS, SARS, 진단, 치료기술, [키워드] acute malaria Benin Control controls coronavirus coronavirus disease COVID-19 detection elicited ELISA ELISAs evaluated false-positive result immune response immune responses Immunity Limited malaria parasites regions respiratory infections SARS SARS-CoV-2 serologic serologic test serologic tests severe acute respiratory syndrome coronavirus 2 Spread Test tropical viruses West Africa zoonoses [DOI] 10.3201/eid2701.203281 PMC 바로가기 [Article Type] Dispatch
Deep Transfer Learning for COVID-19 Prediction: Case Study for Limited Data ProblemsCOVID-19 예측을 위한 심층 전이 학습: 제한된 데이터 문제에 대한 사례 연구Article Published on 2021-01-012022-09-11 Journal: Current medical imaging [Category] 치료기술, [키워드] Accuracy Analysis automated Automatic automatically best Chest chest X-ray Chest X-ray images chest X-rays classification Clinical practice CNN Community computer vision Convolution Convolutional neural networks coronavirus COVID-19 COVID-19 patient dataset deep Deep transfer learning detect develop Diagnosis diagnosis of COVID-19 Early detection Effectiveness helping highest Image analysis inception inceptioNetV3 inceptionResNetV2.. learning Limited not used performance performed problem Research the disease transfer was used X-ray [DOI] 10.2174/1573405616666201123120417 PMC 바로가기 [Article Type] Article
Is the oral cavity a reservoir for prolonged SARS-CoV-2 shedding?구강은 장기간 SARS-CoV-2 배출을 위한 저장소입니까?Case Reports Published on 2021-01-012022-09-11 Journal: Medical Hypotheses [Category] MERS, SARS, 진단, 치료기술, [키워드] Analysis Antiviral effect antiviral effects Asymptomatic COVID-19 can not Care Case fatality rate cells clinically Contagiosity COVID-19 Critical dentistry detect Efficacy effort Fatality rate Health Health care Hypothesis immune system activity innate immune Invasion knowledge limitation Limited mechanism modulate molecular myriad observation oral oral cavity oral tissues pathogenic viruses pathologic Patient patients persistence positive provide Research risk SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 RNA SARS-CoV-2 transmission specimen throat swab tissue to define Transmission virus [DOI] 10.1016/j.mehy.2020.110419 PMC 바로가기 [Article Type] Case Reports
Efficacy and Safety of Inhaled Ciclesonide in Treating Patients With Asymptomatic or Mild COVID-19 in the RACCO Trial: Protocol for a Multicenter, Open-label, Randomized Controlled TrialProtocol Published on 2020-12-312022-10-29 Journal: JMIR Research Protocols [Category] COVID-19, [키워드] administration antipyretics Baseline assessment changes in Ciclesonide clinical Clinical outcome conducted Controlled COVID-19 Data collection determine diagnosed with COVID-19 dose drug Drug administration effective Effectiveness Efficacy endpoint analysis enrolled exclusion criteria expected exploratory Fisher exact test follow-up assessment group groups hospital hypothese Identifier Inclusion Intervention investigator-initiated Japan Laboratory Limited multicenter objective Open-label parallel-group parameter participant Patient patients with COVID-19 peer-reviewed per day performed Pneumonia proposed therapy protocol Randomized Randomized controlled trial receive recruited reduction Registration registry report required Result Safe Safety SARS-CoV-2 statistically significant difference Symptomatic treatment Teijin therapeutic interventions therapeutic option therapy tomography treating Treatment treatment group Trial viral genome [DOI] 10.2196/23830 PMC 바로가기 [Article Type] Protocol
Cognitive impact of COVID-19: looking beyond the short termReview Published on 2020-12-302022-10-28 Journal: Alzheimer's Research & Therapy [Category] COVID-19, MERS, SARS, [키워드] accelerate accumulating ACE inhibitor ACE-2 acute illness angiotensin receptor blocker Angiotensin receptor blockers Angiotensin-converting enzyme angiotensin-converting enzyme inhibitors angiotensin-converting enzyme-2 ApoE cardiorespiratory Central nervous system cerebral classical CNS Cognitive function Cognitive impairment COVID-19 COVID-19 patient current Dementia deplete develop disease Disseminated intravascular coagulation dysfunction Endothelial cell endothelial cells Evidence exacerbate exacerbating expression Follow-up hospitalised patient immune activation increased risk individuals infecting Inflammation inflammatory effect Lewy body Limited lowest medication Meta-analysis nasal mucosa Neurological complication neurons olfactory pathology Patient pericyte pericytes Phosphorylation predicted Protective RAS recent receptor reducing Respiratory disease Respiratory function risk SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 virus Spread stroke suggested Survivors target therapy thrombosis vascular leakage vasculature virus White matter ischaemia [DOI] 10.1186/s13195-020-00744-w PMC 바로가기 [Article Type] Review