Massive dissemination of a SARS-CoV-2 Spike Y839 variant in Portugal포르투갈에서 SARS-CoV-2 Spike Y839 변종의 대규모 보급Research Article Published on 2020-11-252022-09-10 Journal: Emerging Microbes & Infections [Category] MERS, SARS, 변종, 유전자 메커니즘, 치료기술, 치료제, [키워드] anti-viral drug Anti-viral drugs collaboration confirmed case contributing to country COVID-19 COVID-19 case D839Y dissemination Effect Epidemic Epidemics experimental validation exponential phase Frequency functional fusion peptide Genetic variant Genome genomes Genomic epidemiology Genomic surveillance Italy massive motif Mutation peptide Portugal prevalent Region relative frequency required SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variant selective Sequencing spike spike variants Spread Support Surveillance the epidemic the Spike variant variants [DOI] 10.1080/22221751.2020.1844552 PMC 바로가기 [Article Type] Research Article
Rapid High-Yield Production of Functional SARS-CoV-2 Receptor Binding Domain by Viral and Non-Viral Transient Expression for Pre-Clinical EvaluationArticle Published on 2020-11-042022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome added Antigen approaches binding bioreactor Cell cells conformational coronavirus COVID-19 COVID-19 therapeutics COVID-19 vaccine Culture cultures demonstrated downstream efficient Epitopes evaluated exhibited expression functional HEK293SF suspension cells Improvements Infection mechanism media monoclonal antibody motif Neutralizing antibodies Plasmid Production Protein Rapid RBD Research resulting SARS-CoV-2 SARS-CoV-2 Spike Receptor Binding Domain sialic acid spike subunit supernatants Support the RBD protein the Spike Transient transient transfection upstream Vaccine vaccine bioprocess virus [DOI] 10.3390/vaccines8040654 PMC 바로가기 [Article Type] Article
SARS-CoV2 envelope protein: non-synonymous mutations and its consequencesSARS-CoV2 외피 단백질: 동의어가 아닌 돌연변이와 그 결과Article Published on 2020-11-012022-09-11 Journal: Genomics [Category] SARS, 변종, [키워드] Affect analyzed Asia binding C-terminus Complete consequence COVID-19 domain envelope envelope protein Europe Genome genome sequence Genome sequences Guangzhou host protein Missense mutation Missense mutations motif NCBI database Non-synonymous mutation Non-synonymous mutations Oceania PALS1 Protein SARS-CoV2 SARS-CoV2 genomes transmembrane USA Victoria [DOI] 10.1016/j.ygeno.2020.07.001 PMC 바로가기 [Article Type] Article
Unique fibrinogen-binding motifs in the nucleocapsid phosphoprotein of SARS CoV-2: Potential implications in host-pathogen interactionsSARS CoV-2의 뉴클레오캡시드 인단백질의 독특한 피브리노겐 결합 모티프: 숙주-병원체 상호작용의 잠재적 의미Article Published on 2020-11-012022-09-11 Journal: Medical Hypotheses [Category] SARS, 치료법, [키워드] Asymptomatic binding Blood blood clot Blood clots blood clotting cascade clinical manifestation clinical manifestations clinical observation Coagulase Coagulation condition contagious Corona virus coronavirus COVID-19 Critical Critical illness death disease Disseminated intravascular coagulation Economy etiological agent evade fibrinogen function functions global health Health help homologous Host Host immune response host-pathogen interaction Hypothesis immune evasion implication in vitro incidence increase in increased risk induce infected patient infected patients infecting Infection information Interaction intravascular coagulation mechanism Mild molecular mechanisms morbidity and mortality motif Motif. N-protein novel Novel coronavirus nucleocapsid pandemic Potential Protein Proteins prothrombin regulate SARS CoV SARS CoV-2 SARS CoV-2 infection Stage Staphylococcus aureus tested therapeutic strategy turn unique virus von Willebrand factor [DOI] 10.1016/j.mehy.2020.110030 PMC 바로가기 [Article Type] Article
nSARS-Cov-2, pulmonary edema and thrombosis: possible molecular insights using miRNA-gene circuits in regulatory networksResearch Published on 2020-10-302022-10-31 Journal: Exrna [Category] COVID-19, [키워드] accompany Antigen presentation antigen-presentation approach Cell coronavirus 2 Diseases disorder drugs edema Factor Features Feed forward loops FFLs identify Infection Inflammatory response information loop miRNA miRNA coregulatory networks molecular molecular mechanism motif nSARS-CoV-2 pandemic pathophysiology pathway pulmonary disease Pulmonary edema regulate regulatory circuit regulatory network Research respiratory Result Signaling signaling pathway signaling pathways similarity Spread symptomatic targets TGF the disease thromboembolic thrombosis trajectory unique vaccine candidate viral replication virus virus spike protein while [DOI] 10.1186/s41544-020-00057-y PMC 바로가기 [Article Type] Research
Structural basis for potent neutralization of SARS-CoV-2 and role of antibody affinity maturationArticle Published on 2020-10-272022-10-04 Journal: Nature Communications [Category] MERS, SARS, 변종, [키워드] antibody affinity Betacoronavirus bind binding binding affinity competing complex COVID-19 pandemic COVID19 determine effective epitope human ACE2 receptor induce infected with SARS-CoV-2 maturation mechanism monoclonal antibody motif Mutation neutralization Neutralizing neutralizing antibody overlap Patient Receptor binding domain reduction in responsible reveal SARS-CoV-2 the S1 subunit Treatment Vaccine viral infection virus X-ray X-ray crystallography [DOI] 10.1038/s41467-020-19231-9 PMC 바로가기 [Article Type] Article
Remdesivir targets a structurally analogous region of the Ebola virus and SARS-CoV-2 polymerases530 Published on 2020-10-272022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, SARS, [키워드] agent amino acid residue amino acid substitution Antiviral antiviral nucleotide analog approval biosecurity board center characterized clinically evaluated conserved Control Coronaviruses COVID-19 COVID-19 patient disease drug Ebola Ebola virus Emergency use authorization EUA evaluated Filovirus filoviruses food Human humans in vitro Lineage mechanism of action molecular motif Mutation nucleotide nucleotide prodrug Outbreaks passages Patient polymerase Program reduced Remdesivir residue RNA virus SARS-CoV-2 selected Significance subject Surveillance susceptibility susceptible target therapy to define treating COVID-19 Treatment variant virus [DOI] 10.1073/pnas.2012294117 PMC 바로가기 [Article Type] 530
ORF3a mutation associated with higher mortality rate in SARS-CoV-2 infectionOriginal Paper Published on 2020-10-262022-11-01 Journal: Epidemiology and Infection [Category] COVID-19, MERS, SARS, [키워드] acute respiratory distress acute respiratory syndrome affecting amino acid change antigenic diversity association B cell caused change chemokine Complete coronavirus country COVID-19 cytokine-related pathways epitope Extensive functional annotation Genetic variant Genome sequencing globe Host immune response in silico Jak-STAT leucine Modification Mortality mortality rate motif Mutation network analysis ORF3a ORF3a protein pathway Phosphorylation SARS-CoV-2 SARS-COV-2 infection Signal transduction syndrome [DOI] 10.1017/S0950268820002599 PMC 바로가기 [Article Type] Original Paper
Brazilian Consortium for the Study on Renal Diseases Associated With COVID-19: A Multicentric Effort to Understand SARS-CoV-2-Related NephropathyMedicine Published on 2020-10-232022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] ACE2 ADAMTS13 addition analyzed angiotensin-converting enzyme 2 APOL1 appear approach assays association authors Autopsy biopsy Brazil caused CD138 CD20 CD3 CD4 CD57 CD68 CD8 Cell Collapsing glomerulopathy collected complement Complete complex concerning confirmed case coronavirus disease COVID-19 deaths Deceased described detect diagnosed expressing genotyping glomerulopathy help highest IHC include inflammatory cell information involved kidney Kidney disease Kidney injury mechanism Microscopy Morphological morphology motif pathology Patient patients with COVID-19 performed Peripheral blood renal Renal involvement renal tissue respiratory RT-PCR SARS-CoV-2 staining state hospital the patient the United State thrombotic thrombotic microangiopathy tissue university hospital virus with COVID-19 [DOI] 10.3389/fmed.2020.584235 PMC 바로가기 [Article Type] Medicine
Differential Expression of Viral Transcripts From Single-Cell RNA Sequencing of Moderate and Severe COVID-19 Patients and Its Implications for Case SeverityMicrobiology Published on 2020-10-162022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] abundantly expressed Bronchoalveolar lavage fluid Care cell infection rate cells Clinical outcome COVID-19 COVID-19 case COVID-19 patients death detectable differentially expressed event expression feature fusion Health immune implicated infected cell joint macrophages moderate motif NK cells nucleocapsid ORF10 outbreak outcome pathogenesis of COVID-19 Patient patients with moderate predict Predictive progression reported resource RNA SARS-CoV SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 sequence severe cases severe COVID-19 severe patients significantly higher Single Cell T cells the disease the patient the SARS-CoV-2 The United States tissue trajectory transcription regulatory sequence Transcriptome TRS TRSs viral fusion evolution viral gene expression viral transcript virulence Virus evolution virus gene fusion [DOI] 10.3389/fmicb.2020.603509 PMC 바로가기 [Article Type] Microbiology