Ultrapotent miniproteins targeting the SARS-CoV-2 receptor-binding domain protect against infection and diseaseSARS-CoV-2 수용체 결합 도메인을 표적으로 하는 초강력 미니단백질은 감염과 질병으로부터 보호합니다Article Published on 2021-07-142022-09-11 Journal: Cell Host & Microbe [Category] MERS, SARS, 변종, 진단, [키워드] administration approach B.1.1.7 COVID-19 COVID-19 pandemic death develop disease domain dose E484K Immune cell infiltration in vivo Infection Inflammation intranasal investigated lead lung Lung disease mice miniprotein mitigate N501Y Pathogenesis pathology prevented Prophylaxis PROTECT Protein-based vaccines public health measure public health measures Receptor-binding domain reduced SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 spike receptor-binding domain Spike protein spike protein-based vaccine spike protein-based vaccines spike receptor-binding domain strain substitutions Support systemic the SARS-CoV-2 therapy Treatment variants Viral viral burden virus WA1/2020 [DOI] 10.1016/j.chom.2021.06.008 PMC 바로가기 [Article Type] Article
Rhinovirus spread in children during the COVID‐19 pandemic despite social restrictions—A nationwide register study in FinlandShort Communication Published on 2021-07-112022-11-01 Journal: Journal of medical virology [Category] COVID-19, Fulltext, MERS, [키워드] affected age all age groups calculated children circulation coronavirus disease COVID‐19 Epidemiology Finnish FIVE highest incidence Influenza lifted looser Nonpharmaceutical interventions pandemic positive Prevent prevented recorded remained respiratory syncytial virus returned rhinovirus RSV Spread stratified Surveillance used data [DOI] 10.1002/jmv.27180 PMC 바로가기 [Article Type] Short Communication
Big Data Technology Applications and the Right to Health in China during the COVID-19 PandemicCommentary Published on 2021-07-082022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] Accuracy application Big data technology China Chinese constitution Contact tracing Coronavirus pneumonia COVID-19 Diagnosis Efficiency Epidemic epidemic prevention and control Factors Health Human rights Impact individual law outbreak positive prevented PROTECT protection public health resource right Right to Health right to privacy risk Significant supported Surveillance technology Topic Treatment virus [DOI] 10.3390/ijerph18147325 PMC 바로가기 [Article Type] Commentary
Characterization of a new SARS-CoV-2 variant that emerged in Brazil브라질에서 출현한 새로운 SARS-CoV-2 변종 특성 규명Comparative Study Published on 2021-07-062022-09-10 Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition animal model Antigen aspartic acid BNT162b2 Brazil characterization characterized circulating comparable convalescent human plasma convalescent patient Convalescent patients convalescent sera coronavirus COVID-19 deaths glycine hamster hamsters Host host range in viral Infection Japan less Lower respiratory tract Messenger RNA mice multiple mutation multiple mutations neutralization titer Neutralizing antibodies neutralizing antibody new SARS-CoV-2 number of deaths P.1 P.1 variant P.1 variants passive transfer pathogenicity Patient plasma position prevented protective immune response Protein reduced Reinfection Replication replicative respiratory S protein SARS-CoV-2 SARS-CoV-2 disease SARS-COV-2 infection SARS-CoV-2 strain sera serum severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown Significance strain Strains Syrian hamsters the S protein transfer Vaccine vaccinee variant variant of SARS-CoV-2 variants Viral viral infectivity virus replication [DOI] 10.1073/pnas.2106535118 PMC 바로가기 [Article Type] Comparative Study
Overcoming COVID-19 in China despite shortcomings of the public health system: what can we learn?Research Published on 2021-07-062022-10-31 Journal: Health Economics Review [Category] COVID-19, [키워드] applied Care China Contact Contact-tracking technology contributed country COVID-19 COVID-19 pandemic death develop feasible Health Health care system Health codes implementation inefficient liberal Local management measure Measures not differ parameters prevented public health Result second wave System dynamics model the disease the epidemic while Wuhan Wuhan, China [DOI] 10.1186/s13561-021-00319-x PMC 바로가기 [Article Type] Research
Physical Activity, Sedentary Behavior, and Weight Status of University Students during the COVID-19 Lockdown: A Cross-National Comparative StudyArticle Published on 2021-07-032022-10-29 Journal: International Journal of Environmental Research an [Category] Coronavirus, SARS, [키워드] activity age Behavior body weight Comparative correlation COVID-19 COVID-19 pandemic cross-sectional finding form Gender individual Indonesian inverse correlation involved lockdown Malaysian MET no significant difference pandemic physical activity Physical inactivity physically Prevalence prevented reduced Sedentary behavior significantly higher status student suggested the WHO university university students was used weight weight status [DOI] 10.3390/ijerph18137125 PMC 바로가기 [Article Type] Article
The renin-angiotensin system and specifically angiotensin-converting enzyme 2 as a potential therapeutic target in SARS-CoV-2 infectionsSARS-CoV-2 감염의 잠재적인 치료 표적으로서 레닌-안지오텐신 시스템 및 특히 안지오텐신 전환 효소 2Article Published on 2021-07-012022-09-11 Journal: Naunyn-Schmiedeberg's Archives of Pharmacology [Category] SARS, 치료제, [키워드] ACE-2 angiotensin angiotensin-converting enzyme 2 Cardiovascular function caused complex mechanism complex mechanisms country COVID-19 COVID-19 infection COVID-19 pandemic deaths entry receptor explanation hypothese modulation occurred pharmacological potential therapeutic target prevented preventive measure preventive measures protective role Protein RAS Regulation Renin renin-angiotensin system respiratory tract SARS-CoV-2 SARS-CoV-2 coronavirus SARS-COV-2 infection Spread therapeutic intervention Therapeutic strategies vaccination Variation variations viral infection virus Wuhan Wuhan, China [DOI] 10.1007/s00210-021-02108-z PMC 바로가기 [Article Type] Article
Sales of antibiotics and hydroxychloroquine in India during the COVID-19 epidemic: An interrupted time series analysisResearch Article Published on 2021-07-012022-10-29 Journal: PLoS Medicine [Category] COVID-19, SARS, [키워드] acute respiratory syndrome affected Analysis antibiotic antibiotic use Antibiotics antimicrobial approaches azithromycin treatment Bacterial Care change changes in children collected concerning consequence contributed coronavirus coronavirus disease country courses Coverage COVID-19 COVID-19 epidemic COVID-19 pandemic develop dose doses Effect Epidemic epidemic wave examined expected Focusing HCQ healthcare highlighting Hydroxychloroquine include increase in India Infection interval IQVIA lack less limitation lockdown Measures medium occurred pandemic peaked performed predominant prevented Prophylaxis proportion raising reported researcher SARS-CoV-2 significant increase statistical symptomatic the epidemic Treatment use of antibiotics Volume widespread [DOI] 10.1371/journal.pmed.1003682 PMC 바로가기 [Article Type] Research Article
Impact of Remdesivir on the Treatment of COVID-19 During the First Wave in Spain스페인의 첫 번째 물결 동안 렘데시비르가 COVID-19 치료에 미치는 영향Article Published on 2021-07-012022-09-11 Journal: Advances in therapy [Category] SARS, 치료제, [키워드] 95% CI Admission affected approved Bed occupancy country COVID-19 death Europe First wave highest hospitalized patient hospitalized patients ICU ICUs Impact increase in management mortality rate occupancy rate oxygen Patient Pneumonia pressure prevented reduced reduction Remdesivir required Retrospective study Spain Spanish supplemental oxygen System Trial Wave with COVID-19 [DOI] 10.1007/s12325-021-01804-9 PMC 바로가기 [Article Type] Article
Molecular Epidemiology of SARS-CoV-2 in Greece Reveals Low Rates of Onward Virus Transmission after Lifting of Travel Restrictions Based on Risk Assessment during Summer 2020Research Article Published on 2021-06-302022-10-30 Journal: mSphere [Category] COVID-19, [키워드] acute respiratory syndrome added Analysis assessment Bayesian approach circulation Cluster collected Contact tracing coronavirus Coverage Efficacy Epidemiology Evidence expand FIVE globe Greece implication independent International lifting likelihood Local Molecular epidemiology Novel coronavirus onward transmission pandemic Phylogenetic phylogeographic analysis phylogeography prevented proportion provided public health public health measure random Rate reconstructed replicate restriction risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 sequence sequence Spread strain summer Transmission Travel Travel restrictions vaccination variant virus [DOI] 10.1128/mSphere.00180-21 PMC 바로가기 [Article Type] Research Article