Digital Genotyping of Macrosatellites and Multicopy Genes Reveals Novel Biological Functions Associated with Copy Number Variation of Large Tandem RepeatsMacrosatellites 및 Multicopy 유전자의 디지털 유전형 분석은 대규모 직렬 반복의 복사 수 변화와 관련된 새로운 생물학적 기능을 나타냅니다.Research Article Published on 2014-06-192022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accompanied accumulation accumulations Analysis approach approaches association Biological Biological functions changes in copy copy number correlation Digital DNA methylation DNA methylation levels Effect Effects eukaryotic Evolution example expansion extreme FIVE focus fraction function functional Gene Expression Genes Genome genome assembly Genome-wide association study genomes genomic Genotype GWAS hallmark hallmarks human population human populations humans identify include information lead Local loci majority mechanism modulating non-human primates novel nucleotide number Organisms phenotypic diversity Population Previous studies Repeat repeated selective selective pressure sequence significantly single nucleotide single nucleotide variation SNP SNPs suppression tandem tandem repeat tandem repeats transgenic utility Variability variant variants Variation variations [DOI] 10.1371/journal.pgen.1004418 PMC 바로가기 [Article Type] Research Article
Cell Type-Specific Functions of Period Genes Revealed by Novel Adipocyte and Hepatocyte Circadian Clock Models새로운 지방세포 및 간세포 일주기 시계 모델에 의해 밝혀진 기간 유전자의 세포 유형별 기능Research Article Published on 2014-04-032022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] adipocytes Affect amplitude animals Behavior biochemical Bmal1 Brain Cell cell types cellular circadian clock circadian rhythms CLOCK component Cry1 Cry2 Effect evaluated expected Families feasible fibroblasts function Gene Expression Genes Genetic genomic hepatocyte hepatocytes hypothalamus Impact implication Interaction kinetic knockdown knockout mice lentivirus library Local Luminescence mechanism metabolism microplate reader Model molecular negative feedback negative feedback mechanism neurons novel nuclei Per1 Per2 PER3 Period phenotype Physiology Previous studies regulated reporter reveal Revealed RNA RNA interference small molecule Small molecules tissue specific transcriptional [DOI] 10.1371/journal.pgen.1004244 PMC 바로가기 [Article Type] Research Article
Altering SARS Coronavirus Frameshift Efficiency Affects Genomic and Subgenomic RNA ProductionArticle Published on 2013-01-182022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] Affect Altering change changes in coronavirus different Efficiency frameshift Frequency genomic genomic RNA genomic sequence Mutation ORF1a/b Previous studies produced Production protein sequence pseudoknot resulting ribosomal frameshifting RNA RNA sequence SARS Severe acute respiratory syndrome shown synonymous TCID threshold Viral protein viral replication virus virus production [DOI] 10.3390/v5010279 PMC 바로가기 [Article Type] Article
Association of Genetic Variants in Complement Factor H and Factor H-Related Genes with Systemic Lupus Erythematosus Susceptibility보체 인자 H 및 인자 H 관련 유전자의 유전적 변이체와 전신성 홍반성 루푸스 감수성의 연관성Research Article Published on 2011-05-262022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Activation addition African American African Americans allelic American amplification Analysis Asian Asians association Author Autoimmune disease Case-control causal variant CFH CFHR1 CFHR3 CFHR4 CFHR5 chromosome chromosome 1q32 complement Complement activation complex contribute datasets Deletion described detected disease-associated downstream dysregulated Ethnic groups European Evidence exonic exonic SNPs Factor FIVE Gene genes encoding Genetic variant genetic variants genotypic haplotype analysis heterozygous higher risk homozygous human disease human diseases impair intron Intronic locus Lupus lupus erythematosus multiplex Pathogenesis populations Previous studies previous study probe Protein provide provided Regulation Significant SLE SNP SNPs subject suggested susceptibility systemic systemic lupus erythematosus tested variant variants [DOI] 10.1371/journal.pgen.1002079 PMC 바로가기 [Article Type] Research Article
Differential stepwise evolution of SARS coronavirus functional proteins in different host speciesResearch Article Published on 2009-03-052022-10-28 Journal: BMC Evolutionary Biology [Category] Coronavirus, [키워드] adaptive addition Amino acid Analysis bat bats China different Epidemic etiological agent events Evolution found functional protein group Host hosts Human Hypothesis indicated introduced late phase NO pathway patients Positive selection Previous studies previous study Protein representing Result SARS Coronavirus SARS-CoV SARS-like-CoV selective Stage Support target the spike protein wet market [DOI] 10.1186/1471-2148-9-52 PMC 바로가기 [Article Type] Research Article