Human Monocyte Subsets and Phenotypes in Major Chronic Inflammatory DiseasesReview Published on 2019-08-302023-08-30 Journal: Frontiers in Immunology [Category] E형 간염, [키워드] Atherosclerosis diet human monocytes neurodegeneration respiratory diseases [DOI] 10.3389/fimmu.2019.02035 PMC 바로가기 [Article Type] Review
An ADAMTS3 missense variant is associated with Norwich Terrier upper airway syndromeADAMTS3 missense 변종은 Norwich Terrier 상기도 증후군과 관련이 있습니다.Research Article Published on 2019-05-162022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] ADAMTS3 addition affected airway airway obstruction airways Analysis approach association assumed breed Bulldog candidate gene canine caused change characteristic chromosome chromosome 13 contribute Critical determinant determinants disease Disruption dissociate English ENhance error examined ExoN facial feature flat French French bulldog Frequency Genetic genetic association genetic screens genetics Genome genome-wide association Health health screening heterogeneous highlight identify independent independent of Intervention Laryngoscopy loss of function Missense mutation missense variant motif oedema offer overlap pathology performed predisposing factor predisposition presenting prevalent Previous studies previous study prognostics resolved respiratory Respiratory disease respiratory diseases respiratory obstruction risk allele scored screened severity shown skull surgical surgical interventions Symptom syndrome Terrier treat upper upper airway variant variants was used [DOI] 10.1371/journal.pgen.1008102 PMC 바로가기 [Article Type] Research Article
Conditional knockout mice for the distal appendage protein CEP164 reveal its essential roles in airway multiciliated cell differentiation말단 부속기 단백질 CEP164에 대한 조건부 녹아웃 마우스는 기도 다중섬모 세포 분화에서 필수적인 역할을 밝힙니다Research Article Published on 2017-12-152022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence addition affecting airway airways arising Arl13b Asthma basal body binding Brain Cby1 Cell cell differentiation cells CEP164 cerebrospinal fluid characterized chronic obstructive ciliary ciliary dyskinesia circulation clearance component Control COPD Critical cystic fibrosis develop differentiation disease disorder distal docking dysfunction dyskinesia Evidence female reproductive tract fiber fibrosis fluids Genetic genetic disease GTPase Health human biology hydrocephalus implicated Infection infertility knockout mice lack lining male male infertility membrane vesicle membrane vesicles mice modulate molecular mechanism molecular mechanisms Mucociliary clearance Mucus multicilia oviduct Patient Perturbation physiological primary ciliary dyskinesia primary culture Protein Proteins provide recruitment regulate Regulation respiratory respiratory diseases selective Structure Symptom Testis tissue tracheal Transport unique Vesicle while [DOI] 10.1371/journal.pgen.1007128 PMC 바로가기 [Article Type] Research Article
Epidemiology and clinical characteristics of human coronaviruses OC43, 229E, NL63, and HKU1: a study of hospitalized children with acute respiratory tract infection in Guangzhou, ChinaOriginal Article Published on 2017-12-062022-10-31 Journal: European Journal of Clinical Microbiology & Infect [Category] Coronavirus, MERS, [키워드] 229E age children China Clinical characteristics clinical feature clinical manifestation Clinical sign collected coronavirus coughing Epidemiology Evidence Fever group Guangzhou, China highest HKU1 Hospitalized Human human coronavirus Infection less NL63 OC43 Patient PCR Pediatric patient Pneumonia polymerase chain positive Prevalence provide rale respiratory diseases Respiratory pathogens respiratory tract infection respiratory virus Retrospective study significant difference strain subtropical Symptoms tested throat swab [DOI] 10.1007/s10096-017-3144-z PMC 바로가기 [Article Type] Original Article
Sex-based differences in susceptibility to SARS-CoV infectionArticle Published on 2017-04-052023-06-15 Journal: Journal of immunology (Baltimore, Md. : 1950) [Category] MERS, [키워드] estrogen signaling respiratory diseases Rodent model SARS-CoV sex differences [DOI] 10.4049/jimmunol.1601896 PMC 바로가기 [Article Type] Article
Development of transgenic mouse model expressing porcine aminopeptidase N and its susceptibility to porcine epidemic diarrhea virusArticle Published on 2014-12-272022-11-01 Journal: Virus research [Category] Coronavirus, MERS, [키워드] aminopeptidase N animal model APN bovine coronavirus Coronavirus infection Coronaviruses development epidemic diarrhea expressed expressing fusing growth hormone Infection Laboratory mice organs Pathogenesis polyadenylation site Porcine APN Porcine coronaviruses Porcine epidemic diarrhea virus promoter proximal Research respiratory diseases susceptibility susceptible transgene transgenic transgenic mice Transgenic mouse transgenic mouse model virus [DOI] 10.1016/j.virusres.2014.12.024 PMC 바로가기 [Article Type] Article
Performance and clinical validation of the RealStar ® MERS-CoV Kit for detection of Middle East respiratory syndrome coronavirus RNA중동 호흡기 증후군 코로나바이러스 RNA 검출을 위한 RealStar ® MERS-CoV 키트의 성능 및 임상 검증Article Published on 2014-03-282022-09-25 Journal: Journal of Clinical Virology [Category] MERS, 진단, [키워드] Altona Diagnostics amplification analytical sensitivity assays clinical sample comparable coronavirus cross-reactivity Diagnosis diagnostic assay Diagnostic method envelope Epidemiology Frame genomic region Germany Hamburg highly pathogenic IMPROVE Internal control management MERS-CoV MERS-CoV infection MERS-CoV RNA Middle East Middle East respiratory syndrome molecular Munich nucleic acid objective ORF Patient PCR performance real-time RT-PCR Respiratory disease respiratory diseases respiratory pathogen respiratory sample respiratory syndrome coronavirus Result RNA RT-PCR assay RT-PCR kit target region upstream virus WHO World Health Organization [DOI] 10.1016/j.jcv.2014.03.012 PMC 바로가기 [Article Type] Article
Human Coronaviruses: Insights into Environmental Resistance and Its Influence on the Development of New Antiseptic StrategiesReview Published on 2012-11-122022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] acute respiratory syndrome aluminum antiseptic antiseptics-disinfectants Antiviral treatment approach Betacoronavirus biological fluids bronchitis children common cold Coronaviridae family coronavirus described development different Efficacy emerging disease environmental condition environmental survival evaluate found HCoV 229E high risk HKU1 hospital Human human coronavirus human coronaviruses humans immunosuppressed patients Infection infections infective influence insight involved knowledge lack led to management mean methodology Neonates New NL63 nosocomial OC43 outbreak pathogen pathogenicity Pneumonia Prevent resistance respiratory diseases responsible RNA virus SARS-CoV specific treatment specificity Spread Strategy Support surgical temperature the Coronaviridae upper respiratory tract viral infections viruses [DOI] 10.3390/v4113044 PMC 바로가기 [Article Type] Review
Structural Bases of Coronavirus Attachment to Host Aminopeptidase N and Its Inhibition by Neutralizing AntibodiesResearch Article Published on 2012-08-022022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] acute respiratory syndrome aminopeptidase aminopeptidase N antibody antigenic Antiviral APN attachment Author base binding blocked Cancer Cancer therapy Cell cell entry cell entry receptor cell membrane colds complex coronavirus CoV CoVs crystal structure determinant determine dimeric drugs ectodomain engage enteric diseases facilitate gastroenteritis Host host cells Human immune immune response in some Infection infections Infectious disease information inhibition Interaction membrane-bound neutralization Neutralizing antibodies neutralizing antibody Prevent Protein RBDs receptor Receptor binding receptor binding motif related reported residue respiratory diseases shown specificity spike glycoprotein Strains subsequent subset TGEV the RBD the receptor-binding domain the S protein unique Vaccines virus virus particle viruses [DOI] 10.1371/journal.ppat.1002859 PMC 바로가기 [Article Type] Research Article