Insights into RNA synthesis, capping, and proofreading mechanisms of SARS-coronavirusArticle Published on 2014-10-162022-11-01 Journal: Virus research [Category] Coronavirus, [키워드] activity Biochemistry capping complex coronavirus coronavirus RNA CoVs enzyme exonuclease Factors function Genome highlighting highly active highly pathogenic in vitro insight involved mechanism mechanisms MERS-CoV methyltransferase Middle East Molecular biology positive-sense Proofreading provided replicate Replication Research respiratory RNA RNA polymerase RNA synthesis RNA virus RNA-dependent RNA polymerase SARS Coronavirus SARS-coronavirus SARS-CoV single-stranded stimulated unique [DOI] 10.1016/j.virusres.2014.10.008 PMC 바로가기 [Article Type] Article
Regulation of p53 and Rb Links the Alternative NF-κB Pathway to EZH2 Expression and Cell Senescencep53 및 Rb의 조절은 대체 NF-κB 경로를 EZH2 발현 및 세포 노화에 연결합니다Research Article Published on 2014-09-252022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activated Activation alternative NF-κB pathway Analysis ANAPC1 c-Rel cancer cell Cancer cells CD40 CD40 ligand CD40L CDK4 CDK6 Cell cell cycle cell senescence cellular senescence ChIP chromatin immunoprecipitation chronic chronic lymphocytic leukemia classical complexes Crosstalk de-repression defined Degradation DEK dependent on Effect effector effectors expression EZH2 fibroblasts Hematological malignancies Hematological malignancy IKK IKKα induce inhibit investigated IκB IκBα knockdown leads Loss Lymphocytic leukemia mechanism microarray analysis microenvironment NEMO NF-κB NF-κB inducing kinase NF-κB pathway NF-κB2 NIK or canonical oxygen p100 p21WAF1 p52 p53 pathway patients phenotype Phosphorylation polycomb protein promote protein stability provide PSMA5 quantitative PCR RacGAP1 reactive oxygen species reactive oxygen specy regulate Regulation regulatory subunit RELA RelB repression retinoblastoma retinoblastoma protein ROS SASP senescence senescent siRNA solid tumors stability stimulated subset subunit subunits suppress suppression target gene Target genes the cell Tumor tumor suppressor tumorigenesis tumors tumour suppressor turn western blot Western blot analyses Western blot analysis wild type [DOI] 10.1371/journal.pgen.1004642 PMC 바로가기 [Article Type] Research Article
Structural Basis for the Ubiquitin-Linkage Specificity and deISGylating Activity of SARS-CoV Papain-Like ProteaseResearch Article Published on 2014-05-222022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] 3D structure abrogated activate activated activity acute respiratory syndrome amino acid residue B-cell Basis binding cleaving complex coronavirus distal domain DUB ENCODE enzyme function Genome help higher affinity highlight Host host cell hydrolysis identify in viral inhibited innate immune response interact Interaction interferon involved ISG15 mechanism MERS Middle East molecular mutant mutated NFκB nuclear Papain-like protease Pathogenesis PLPro polyprotein post-translational modification Protease activity Protein Proteins provide reduced required residue residues respiratory reveal SARS virus SARS-CoV short circuit signaling molecule signaling pathway significantly similar study specificity stimulated substrate substrates thumb unique viral replication virus was determined X-ray [DOI] 10.1371/journal.ppat.1004113 PMC 바로가기 [Article Type] Research Article
Regulation of Programmed Ribosomal Frameshifting by Co-Translational Refolding RNA HairpinsResearch Article Published on 2013-04-292022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] 293T cells base pair base-pair determined disrupt downstream Efficiency example functional Hairpin in vitro mechanism provide Regulation regulatory element required reveal RNA RNA structure SARS Coronavirus SARS-CoV sequence variation shown stability stimulated translational upstream yeast [DOI] 10.1371/journal.pone.0062283 PMC 바로가기 [Article Type] Research Article
Evaluation on the Efficacy and Immunogenicity of Recombinant DNA Plasmids Expressing Spike Genes from Porcine Transmissible Gastroenteritis Virus and Porcine Epidemic Diarrhea VirusResearch Article Published on 2013-03-192022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] addition analyzed Antibody Response Antigen CD4+ CD8+ change CTL development diarrhea DNA DNA plasmid DNA vaccine effective vaccine epidemic diarrhea eukaryotic expression vector full-length S gastroenteritis Gene IFN-γ immunized mice immunogenicity induce inoculated kinetic Measures mice Neutralization antibody neutralizing antibody Open reading frame PEDV performed plasmids proliferation Protein recombinant DNA resulting S1 protein specific antibody spike stimulated subgroup subgroups Surface glycoprotein T lymphocyte TGEV vaccination virus Virus neutralization [DOI] 10.1371/journal.pone.0057468 PMC 바로가기 [Article Type] Research Article
Genome-Wide Analysis of Protein-Protein Interactions and Involvement of Viral Proteins in SARS-CoV ReplicationResearch Article Published on 2008-10-012022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] adopted assays biochemical complex coronavirus Coronavirus replication detected domain expressing found function in vitro Interaction Involvement mammalian mechanism molecular mechanisms multifunctional Nidovirale non-structural protein Nsp12 nsp14 Nsp3 platform Protein protein-protein interaction Proteins provided regulate reporter RNA genome SARS Coronavirus SARS-CoV sequence shown stimulated to screen Transcription unique Viral protein viruses [DOI] 10.1371/journal.pone.0003299 PMC 바로가기 [Article Type] Research Article
Lowered yields of virus-induced interferon production in leukocyte cultures and risk of recurrent respiratory infections in childrenArticle Published on 1999-11-292022-11-01 Journal: Journal of Clinical Virology [Category] Coronavirus, [키워드] Adenovirus age Blood Child children coronavirus correlation Culture cultures defined enrolled entire cohort Finnish follow-up period Genetic greater group highest IFN IFN response interferon leukocyte not differ objective otitis otitis media produced respiratory infection respiratory infections Result rhinovirus risk selected statistically significant difference stimulated upper respiratory infection variations virus viruses was measured [DOI] 10.1016/S1386-6532(99)00056-6 PMC 바로가기 [Article Type] Article