Impact of COVID-19 Confinement on Adolescent Patients with Anorexia Nervosa: A Qualitative Interview Study Involving Adolescents and ParentsArticle Published on 2021-04-162022-10-30 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, SARS, [키워드] Adolescent adolescents anorexia anorexia nervosa asked changes in clinical clinician cohorts compulsion conducted confinement Contact COVID-19 Deterioration disorders expressed female Impact implication improvement include interview involved Involving joint less parent parents Patient patients positive psychological Impact Qualitative qualitative study receiving reduced risk semistructured interview Stress structures Symptom Symptoms tension thematic analysis Treatment triggering [DOI] 10.3390/ijerph18084251 PMC 바로가기 [Article Type] Article
The antigenic anatomy of SARS-CoV-2 receptor binding domainSARS-CoV-2 수용체 결합 도메인의 항원 해부학Article Published on 2021-04-152022-09-12 Journal: Cell [Category] MERS, SARS, 진단, [키워드] Abstract ACE2 blockers Anatomy animal models antibody antibody binding site antigenic bind binding binding domain binding mode complex coronavirus, SARS-CoV-2, anti-RBD antibody, receptor binding domain, antibody, immune responses, virus structure data-driven dissect Emergency use epitope example Fab glycosylated human antibody response Human monoclonal antibody identify immune protection inhibitory inhibitory antibody Interaction mAb mAbs Map mapped Microscopy MOST N-terminal domain neutralize Neutralizing neutralizing antibody NTD panel of antibody prophylactically PROTECT Protein RBD RBD binding receptor Receptor binding domain recognizing Recovered COVID-19 patients SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor structures the RBD unique Virus spike X-ray crystallography [DOI] 10.1016/j.cell.2021.02.032 PMC 바로가기 [Article Type] Article
Involving clinicians in management: assessing views of doctors and nurses on hybrid professionalism in clinical directoratesResearch Article Published on 2021-04-152022-10-28 Journal: BMC health services research [Category] Coronavirus, MERS, SARS, [키워드] added authority change changes in Characteristics Clinical directorate clinician Clinician engagement COVID-19 COVID-19 pandemic doctor Doctors Drawing effective eight greater healthcare Healthcare professional hospital hospitals hybrid Hybrid professionalism hybridization implementation implication increase in investigated Involving Italy limitation management Nurse Nurses overlap questionnaire reported Research response Result returned Standardization structures while [DOI] 10.1186/s12913-021-06352-0 PMC 바로가기 [Article Type] Research Article
A Review of Impact of Textile Research on Protective Face MasksReview Published on 2021-04-132022-10-30 Journal: Materials [Category] COVID-19, [키워드] addition addressed adverse effect Anti-viral benefit caused change Complete complex conducted COVID-19 COVID-19 disease Critical develop Efficacy Efficiency face Face mask Face masks facemask global pandemic Human Impact Mask mechanism MOST Nanoparticles pandemic physical problem professional PROTECT Protective recommendations Research review risk SARS-CoV-2 Structure structures textile textiles Transmission Treatment university viruses [DOI] 10.3390/ma14081937 PMC 바로가기 [Article Type] Review
COVID-19 Management in the Pediatric Age: Consensus Document of the COVID-19 Working Group in Paediatrics of the Emilia-Romagna Region (RE-CO-Ped), ItalyReview Published on 2021-04-082022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, SARS, [키워드] accumulated acute respiratory syndrome age approach Care carried caused Characteristics children clinical experience Clinical management Consensus coronavirus coronavirus disease COVID-19 COVID-19 pathology criteria database death defined develop document Emilia-Romagna group Health highlight hospital Hospitalization include infected children Italy knowledge literature majority management MIS-C not affected paediatrics pandemic pediatric pediatrics problem professional reduction in Region Research resulting SARS-CoV-2 SARS-COV-2 infection Severe case Spread structures the SARS-CoV-2 therapeutic Treatment working [DOI] 10.3390/ijerph18083919 PMC 바로가기 [Article Type] Review
A COVID-19 Drug Repurposing Strategy through Quantitative Homological Similarities Using a Topological Data Analysis-Based FrameworkArticle Published on 2021-04-022022-10-28 Journal: Pharmaceutics [Category] COVID-19, [키워드] 3CL accelerate analyses applied candidate carried COVID-19 death Dexamethasone drug Drug repurposing effective effort Final framework global pandemic identify in silico molecular docking persistent Betti function produced protease Protein repurposing RNA-dependent RNA polymerase SARS-COV-2 infection Scientific community Strategy Structure structures the SARS-CoV-2 topological data analysis transcriptomic treat Treatment Viral protein [DOI] 10.3390/pharmaceutics13040488 PMC 바로가기 [Article Type] Article
Lead compounds for the development of SARS-CoV-2 3CL protease inhibitorsSARS-CoV-2 3CL 프로테아제 억제제 개발을 위한 리드 화합물Article Published on 2021-04-012022-09-10 Journal: Nature Communications [Category] SARS, 신약개발, [키워드] 3CL complex Compound compounds crystal structures drug target effective identify in vitro inhibitor inhibitors leads Molecular medicine protease Protease inhibitor protease inhibitors SARS-CoV-2 Structure structures the SARS-CoV-2 these compound these compounds Virology X-ray crystallography [DOI] 10.1038/s41467-021-22362-2 PMC 바로가기 [Article Type] Article
Effects of SARS-CoV-2 mutations on protein structures and intraviral protein-protein interactionsSARS-CoV-2 돌연변이가 단백질 구조 및 바이러스 내 단백질-단백질 상호작용에 미치는 영향Article Published on 2021-04-012022-09-11 Journal: Journal of medical virology [Category] SARS, 변종, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Affect affected analyzed binding affinity caused changes in Characteristics complexes coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Diagnosis docking Effect Frame globe Impact in some incidence incidence rate incidence rates Interaction interface investigated involved mutant Mutation nonsynonymous mutation Novel coronavirus nucleocapsid occurred Occurrence ORF3a ORF8 pandemic physiological Protein protein interactions protein sequence protein structure protein-protein interaction Q57H RMSD SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 mutation SARS-CoV-2 mutations SARS-CoV-2 transmission severe acute respiratory syndrome Coronavirus Spread Structure structures the binding affinity the SARS-CoV-2 genome Treatment variance Viral protein virus genome [DOI] 10.1002/jmv.26597 PMC 바로가기 [Article Type] Article
An update to monoclonal antibody as therapeutic option against COVID-19Review article Published on 2021-04-012022-10-05 Journal: Biosafety and Health [Category] 신약개발, [키워드] administration Antibody therapy approval clinical trial complications conducted coronavirus country COVID-19 COVID-19 disease disease drug Ebola effective Emergency use authorization EUA FDA food General population host cells immune response individuals Infection mAb mAbs mechanism of action monoclonal monoclonal antibody Population respiratory syncytial virus RSV SARS-CoV-2 structures therapeutic option treat Vaccine vaccine availability [DOI] 10.1016/j.bsheal.2021.02.001 [Article Type] Review article
Effects of cigarette smoking on SARS-CoV-2 receptor ACE2 expression in the respiratory epithelium †호흡기 상피에서 SARS-CoV-2 수용체 ACE2 발현에 대한 흡연의 영향 †Comment Published on 2021-04-012022-09-11 Journal: The Journal of pathology [Category] SARS, 유전자 메커니즘, [키워드] ACE2 ACE2 expression ACE2 receptor acute respiratory syndrome coronavirus airway airway epithelium apical surface cellular entry cigarette smoke cigarette smoking coronavirus 2 COVID-19 COVID-19 symptom COVID-19 symptoms Effect experimental model experimental models future therapeutic gene expression datasets Great Britain highlight human lung tissue implication increase Ireland journal limitation Lung injury morbidity and mortality mortality rates murine model pandemic pathological pathology respiratory respiratory epithelium risk of transmission SARS-CoV-2 SARS-CoV-2 receptor Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 smoke smoking smoking cessation Society Sons structures virus [DOI] 10.1002/path.5607 PMC 바로가기 [Article Type] Comment