Emerging Therapeutic Strategies for COVID-19 patientsFocused Review Published on 2020-03-122022-11-01 Journal: Discoveries [Category] COVID-19, [키워드] 2019-nCoV abidol antibody Chloroquine phosphate coronavirus COVID-19 COVID-19 patient deaths effective lopinavir/ ritonavir Novel coronavirus over Patient plasma Potential Remdesivir reported resulting SARS-CoV-2 stem cell Strategy therapeutic intervention Therapeutic strategies Vaccine [DOI] 10.15190/d.2020.2 PMC 바로가기 [Article Type] Focused Review
Cardiovascular involvement in COVID-19: not to be missedReview Article Published on 2020-01-012022-10-28 Journal: Brazilian Journal of Cardiovascular Surgery [Category] COVID-19, MERS, [키워드] ACE2 angiotensin converting enzyme 2 angiotensin-converting enzyme 2 binding Cardiopulmonary cardiovascular cardiovascular disease cardiovascular diseases cardiovascular system clinical decision Clinical management coagulation disorder COVID-19 D-dimer level died endothelial expressed extracorporeal membrane oxygenation extreme Frequency human cell IMV indicate Inflammatory inflammatory process Injury Invasive mechanical ventilation Lung compliance lung tissue Manifestations mechanical ventilation modulation myocardial damage myocardial injury myocarditis Novel coronavirus oxygen saturation pandemic Patient Pneumonia, viral positive Prevent progression Prothrombin time pulmonary conditions responsible SARS-CoV2 SARS-CoV2 infection severe respiratory infection Signaling standard treatment the spike protein Therapeutic strategies venous Ventilation Viral pneumonia Wuhan [DOI] 10.21470/1678-9741-2020-0224 PMC 바로가기 [Article Type] Review Article
Porcine Hemagglutinating Encephalomyelitis Virus Enters Neuro-2a Cells via Clathrin-Mediated Endocytosis in a Rab5-, Cholesterol-, and pH-Dependent MannerVirus-Cell Interactions Published on 2017-09-272022-10-30 Journal: Journal of Virology [Category] Coronavirus, [키워드] Actin activated Activation Analysis antiviral drug approach cause Cell cells cellular entry Central nervous system China cholesterol clathrin Clathrin-mediated endocytosis CNS confocal microscopy contagious coronavirus death disease dissect dominant negative dysfunction Encephalomyelitis endocytic pathways endocytosis etiological agent Exocytosis GTPase Guidance Host infected cell Infection Invasion investigated involved knowledge mechanism molecular mechanism mutant nerve cell Neural neurological neurovirulent neurovirulent coronavirus occur overexpression Pathogenesis pathway performed pharmacological porcine hemagglutinating encephalomyelitis virus positive-sense positively correlated progression Rab required RNA coronavirus RNA interference single-stranded suggested target TEM Therapeutic strategies transfer transmission electron microscopy understanding viral endocytosis viral entry viral entry pathway virus virus particles were used [DOI] 10.1128/JVI.01083-17 PMC 바로가기 [Article Type] Virus-Cell Interactions
Rescuing the aberrant sex development of H3K9 demethylase Jmjd1a-deficient mice by modulating H3K9 methylation balanceH3K9 메틸화 균형을 조절하여 H3K9 탈메틸화효소 Jmjd1a 결핍 마우스의 비정상적인 성 발달 구조Research Article Published on 2017-09-262022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activities activity administration approach balance biological function Cancer chromatin complex core histones deficiency demethylase demonstrated Diseases DNA Embryo embryonic enzyme Epigenetic eukaryotes expression Genetic hallmark heterochromatin heterozygous histone histone methylation Histones inhibitor initiate intellectual disability leads locus lysine mammals Methylation methyltransferase mice Modification modulating modulation molecular mechanism mutant Mutation pharmacological phenotype principle proof provide rescued reveal Sex Sex determination Therapeutic strategies therapeutic strategy transcriptional regulation transcriptionally tuning [DOI] 10.1371/journal.pgen.1007034 PMC 바로가기 [Article Type] Research Article
Porcine Epidemic Diarrhea Virus Induces Autophagy to Benefit Its ReplicationArticle Published on 2017-03-192022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] accelerate Analysis Apoptosis autophagy autophagy machinery benefit caused complex interplay confocal microscopy demonstrated effective epidemic diarrhea expression Infection Inflammatory cytokine Inflammatory responses NF-κB signaling Pathogenesis pathway PEDV PEDV replication positive feedback loop Replication reported Research RNA interference Therapeutic strategies transmission electron microscopy triggered virus virus infection [DOI] 10.3390/v9030053 PMC 바로가기 [Article Type] Article