Treatment and research lines for the patient with COVID-19. What do we have and where are we going?Review Article Published on 2020-07-272022-10-29 Journal: International Brazilian Journal of Urology : official journal of the Brazilian Society of Urology [Category] COVID-19, SARS, [키워드] acute respiratory syndrome caused clinical trial coronavirus Coronavirus disease 2019 COVID-19 COVID-19 diagnostic testing [Supplementary Concept] COVID-19 pandemic effort Evidence global public health pandemic potential therapy Primary prevention quarantine Research resource SARS-CoV-2 the patient therapeutic strategy Treatment with COVID-19 [DOI] 10.1590/S1677-5538.IBJU.2020.S118 PMC 바로가기 [Article Type] Review Article
Efficacy and safety of Lianhua Qingwen combined with conventional antiviral Western Medicine in the treatment of coronavirus disease (covid-19) in 2019 Protocol for a systematic review and meta-analysis4400 Published on 2020-07-242022-10-30 Journal: Medicine [Category] COVID-19, SARS, [키워드] addition Antiviral antiviral drug approval articles asymptomatic infection bias risk CBM center China clinical Clinical efficacy clinical trial CNKI control group Conventional coronavirus disease cough country COVID-19 crown curative database effective Efficacy and safety eligible Ethics evaluate events Evidence experiments Fever Handbook identify independent Intervention lianhua qingwen manual measure Medicine Meta-analysis Methodological quality Netherland nonrandomized Novel coronavirus outcome Pneumonia protocol regions Registration Safe searched spread to Symptoms systematic review Systemic review Traditional Chinese medicine Treatment trials VIP was used were used [DOI] 10.1097/MD.0000000000021404 PMC 바로가기 [Article Type] 4400
Potential Anti-COVID-19 Therapeutics that Block the Early Stage of the Viral Life Cycle: Structures, Mechanisms, and Clinical TrialsReview Published on 2020-07-232022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] ACE2 acute respiratory syndrome block caused Clathrin-mediated endocytosis clinical clinical trial clinical trials combating coronavirus Coronavirus-2 COVID-19 described disease early stage effective endocytosis ENhance enzyme facilitate Health care system Host host protein include Infection lack life macromolecule mechanism mechanisms monoclonal antibodies pandemic polypeptides Potential presenting Prevent protease PROTECT reported researcher SARS-CoV-2 serine 2 small molecule Spike protein Stage structures sulfated polysaccharides target Therapeutics TMPRSS2 transmembrane treat Vaccine viral entry viral fusion viral infection viral life cycle viral spike protein [DOI] 10.3390/ijms21155224 PMC 바로가기 [Article Type] Review
Expedited COVID-19 vaccine trials: a rat-race with challenges and ethical issuesPerspectives Published on 2020-07-222022-10-28 Journal: The Pan African Medical Journal [Category] COVID-19, MERS, SARS, [키워드] candidate vaccine clinical trial COVID-19 COVID-19 vaccine COVID-19 virus drugs Ethics global effort management media molecular target MONITOR pandemic platform Research resource risk the vaccine timelines Trial Vaccine Vaccine development Volunteer [DOI] 10.11604/pamj.2020.36.206.23977 PMC 바로가기 [Article Type] Perspectives
Evaluation of Current Therapies for COVID-19 TreatmentReview Published on 2020-07-222022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] Analysis Anticoagulant antivirals Chemotherapy clinical trial clinical trials COVID-19 current death Efficacy and safety etiological agent Evidence Lung infection MERS multiple organ failure potential benefits Preliminary data responsible SARS-CoV SARS-CoV-2 soluble ACE2 Therapies therapy threshold treat Treatment virus [DOI] 10.3390/microorganisms8081097 PMC 바로가기 [Article Type] Review
Nebulised heparin as a treatment for COVID-19: scientific rationale and a call for randomised evidenceReview Published on 2020-07-222022-11-01 Journal: Critical Care [Category] COVID-19, [키워드] Activation acute lung injury acute respiratory distress addition Anti-inflammatory Anti-viral ARDS association Bronchoalveolar lavage fluid Clinical deterioration clinical outcomes clinical study clinical trial Coagulation Coagulopathy condition COVID-19 COVID-19 patients dead Diffuse alveolar damage effective Evidence feature hyaline membrane IMPROVE infected with SARS-CoV-2 Inflammatory Inflammatory cytokine Inhaled inhibiting limit mammalian cells Microvascular thrombosis nebulised heparin outcome Patient patients plasma Prevent Pulmonary infection randomised reduce mortality reduced Respiratory disease resulting SARS SARS-CoV-2 severe disease shown syndrome the SARS-CoV-2 virus therapeutic therapeutic potential Treatment unfractionated heparin urgent investigation ventilatory support [DOI] 10.1186/s13054-020-03148-2 PMC 바로가기 [Article Type] Review
Profiles of COVID-19 clinical trials in the Chinese Clinical Trial RegistryReview Published on 2020-07-222022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, MERS, SARS, [키워드] adopted anti-viral drug Anti-viral drugs caused Characteristics Chinese clinical clinical study clinical trial clinical trials comprehensive analysis COVID-19 COVID-19 pandemic COVID19 Effect effective drug effort global public health Government help identify International Intervention outcome profile public health Registered registry resource significantly supported Traditional Chinese medicine Vaccine virus [DOI] 10.1080/22221751.2020.1791736 PMC 바로가기 [Article Type] Review
The rationale of using mesenchymal stem cells in patients with COVID‐19 ‐related acute respiratory distress syndrome: What to expectHuman Clinical Article Published on 2020-07-212022-10-28 Journal: Stem cells translational medicine [Category] COVID-19, SARS, [키워드] acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome alveolar alveolar cell Antiviral approach approved ARDS Cell Clinical management Clinical outcome clinical trial clinical trials clinics compassionate use coronavirus coronavirus disease COVID‐19 COVID‐19 patients COVID‐19 Critical critical appraisal Cytokine storm death demonstrated develop disorder dysfunction effective Efficacy endogenous repair feature Health ICU immune response immune system Immunocompromised immunomodulation infections inflammatory disease inhibiting intensive care lung edema Lung function Mesenchymal stem cells microenvironment MSC MSCs multiorgan failure outcome pandemic Patient rapid progress Registered resulting SARS‐CoV‐2 stem cell syndrome the patient therapeutic Therapeutic approach therapeutic potential tissue source Treatment Trial trials type I was tested [DOI] 10.1002/sctm.20-0164 PMC 바로가기 [Article Type] Human Clinical Article
Antimalarial and cytotoxic drugs on COVID-19 and the cardiovascular burden: Literature review and lessons to be learnedCOVID-19 및 심혈관 부담에 대한 항말라리아 및 세포독성 약물: 문헌 검토 및 배울 교훈Review Published on 2020-07-212022-09-10 Journal: Vascular [Category] MERS, SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adverse drug reaction Adverse drug reactions antiviral activity Azithromycin best bleeding cardiac cardiac injury cardiovascular burden Chloroquine clinical evidence clinical trial clinical trials coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 demonstrated disorder drug Endothelial dysfunction Evidence evidence of focus Google Scholar Guidance Hospitalized hospitalized patients Hydroxychloroquine hydroxychloroquine plus azithromycin in vitro increasingly Injury literature literature review Neuropathology Patient care Remdesivir reported resource Result review severe acute respiratory syndrome Coronavirus stroke systemic inflammation thrombosis thrombotic thrombotic microangiopathy was performed [DOI] 10.1177/1708538120941635 PMC 바로가기 [Article Type] Review
Mechanisms Underlying Potential Therapeutic Approaches for COVID-19Immunology Published on 2020-07-212022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome approaches Betacoronavirus caused clinical trial Contact coronavirus COVID-19 COVID-19 case COVID-19 pandemic Cytokine storm cytokine treatment disease distress Drug administration Efficacy future therapeutic immune therapy Inflammation Isolation Lung injury majority mechanism monoclonal antibody non-specific Patient Potential Prevent Replication respiratory distress SARS-CoV-2 SARS-CoV-2 cell infection Spread Stage the cytokine storm the disease Transmission Treatment virus [DOI] 10.3389/fimmu.2020.01841 PMC 바로가기 [Article Type] Immunology