The Murine Coronavirus Hemagglutinin-esterase Receptor-binding Site: A Major Shift in Ligand Specificity through Modest Changes in ArchitectureResearch Article Published on 2012-01-262022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] absence architecture Author Bacteria betacoronavirus binding binding site cell tropism change changed changes in complex consequence coronavirus coronavirus Coronaviruses domain domains Evolution example Factor glycan glycoprotein Hemagglutinin-esterase Interaction Ligand Lineage living cell Major MHV modifications MOST mouse hepatitis virus murine organ Pathogenesis Protein Protozoa receptor resolved shift sialic acid specificity sugar Topology vertebrates virion virus [DOI] 10.1371/journal.ppat.1002492 PMC 바로가기 [Article Type] Research Article
Identification of a Genomic Reservoir for New TRIM Genes in Primate Genomes영장류 게놈에서 새로운 TRIM 유전자에 대한 게놈 저장소 식별Research Article Published on 2011-12-012022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] African antiviral gene antiviral genes Author best Biology characterized chromosome chromosome 11 Cluster compared copy number Defense described determine Divergence duplication duplications Evolution expressed found Gene gene cluster Genes Genome genomes Han Chinese HIV Human Human genome human population identification immune system individual innate immune response innate immune system Innate immunity locus majority mechanism MOST natural selection neutralized New pathogen Pathogens positive primate primates question Region reservoir restrict restriction factor retroviral rhesus macaques screened selected Specificities target specificity Tripartite Motif ubiquitin ligase virus recognition viruses young gene [DOI] 10.1371/journal.pgen.1002388 PMC 바로가기 [Article Type] Research Article
Phylogenetic distribution and predominant genotype of the avian infectious bronchitis virus in China during 2008-2009Research Published on 2011-04-222022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] age Amino acid amino acids sequence amplified Analysis bronchitis caused Characteristics China circulating cleavage site coding region death different distribution Gene Genotype homology IBV indicated infectious Infectious Bronchitis Virus isolate molecular MOST nucleotide Outbreaks pandemic predominant Prevalence Protein Result RT-PCR S1 protein sequenced strain Strains suggested trials Vaccine virus [DOI] 10.1186/1743-422X-8-184 PMC 바로가기 [Article Type] Research
Human rhinovirus infection in young African children with acute wheezingResearch Article Published on 2011-03-152022-10-28 Journal: BMC Infectious Diseases [Category] Coronavirus, [키워드] African age analysed Analysis caused Characteristics children circulating clinical disease Culture deaths detect detected determine enrolled Fisher group hospital Hospitalized HRV Human In-hospital increasingly Infection information intensive care métapneumovirus Mild moderate monoclonal antibody morbidity MOST nasal swab occurred other respiratory virus PCR-based assays presenting presenting symptom respiratory virus Result reverse transcription PCR rhinovirus rhinovirus South therapy to screen Treatment Trigger viral infection was performed was used wheezing [DOI] 10.1186/1471-2334-11-65 PMC 바로가기 [Article Type] Research Article
Infidelity of SARS-CoV Nsp14-Exonuclease Mutant Virus Replication Is Revealed by Complete Genome SequencingResearch Article Published on 2010-05-062022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] accumulate acute respiratory syndrome Author bioinformatics clone compared competent Complete complex consensus genome coronavirus coronavirus exoribonuclease Coronaviruses Critical Culture decrease deep sequencing demonstrated Effect Evolution examined experiment Frequency full-length genome Genetic Genome genome replication genome sequence growth Impact in vitro inactivation increase in Infidelity lack less limit mechanism MOST murine hepatitis virus mutant mutant virus Mutation nonstructural protein nonstructural protein 14 nsp14 nsp14-ExoN Nsps passage Pathogenesis powerful tool quasispecy recognize Replication replication fidelity required resulting Revealed RNA genome RNA genomes RNA virus SARS-coronavirus SARS-CoV sequence stability the Coronaviridae to define total population unique viral growth viral replication viral RNA genome viral system virus virus wild-type SARS-CoV [DOI] 10.1371/journal.ppat.1000896 PMC 바로가기 [Article Type] Research Article
Immunohistochemistry for detection of avian infectious bronchitis virus strain M41 in the proventriculus and nervous system of experimentally infected chicken embryosResearch Published on 2009-02-052022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] addition Affect age Allantoic fluid Antigen Brain bronchitis Cell chorioallantoic collected detected Diagnosis diagnostic different disease Embryo embryonic embryos fixed found gastrointestinal tract generate IBV IBV infection IHC immunohistochemistry induce Infected Infection Infectious Bronchitis Virus inoculated kidney kidneys liver lung M41 membrane MOST Myocardial nasal epithelium nervous system Neuron oviduct Pathogenesis PI Respiratory system Result sensitivity spleen strain Strains tissue tissue tropism vasculature virulence virus virus isolation [DOI] 10.1186/1743-422X-6-15 PMC 바로가기 [Article Type] Research
Antigenic characterization of severe acute respiratory syndrome-coronavirus nucleocapsid protein expressed in insect cells: The effect of phosphorylation on immunoreactivity and specificityArticle Published on 2007-05-112022-11-01 Journal: Virus research [Category] Coronavirus, [키워드] Analysis Antigen antigenic antigenicity assay baculovirus coronavirus correlation cross-reactivity determine diagnostic E. coli expressed facilitate immunoreactivity insect cell insect cells involved mAb molecular MOST N protein nucleocapsid nucleocapsid protein pathology phosphorylated Phosphorylation produced Protein protein phosphatase 1 reduced Research SARS infection SARS-CoV SARS-CoV N SARS-CoV N protein serum Severe acute respiratory syndrome specificity treated were expressed [DOI] 10.1016/j.virusres.2007.03.019 PMC 바로가기 [Article Type] Article
Long-Term Persistence of Robust Antibody and Cytotoxic T Cell Responses in Recovered Patients Infected with SARS CoronavirusResearch Article Published on 2006-12-202022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] against SARS-CoV Analysis antibody change changes in characterized clinical recovery CTL CTL epitope cytotoxic effective found humoral immune response immunological implication individual individuals Infected Infection Intervention moderate MOST N protein onset of symptoms outcome Patient peptides peripheral lymphocyte persistence recovered recovered patient response responses restored robust SARS Coronavirus SARS-CoV SARS-CoV-specific antibody study period subject Support T cell the disease therapeutic agent Vaccine [DOI] 10.1371/journal.pone.0000024 PMC 바로가기 [Article Type] Research Article
Human Coronavirus-NL63 infections in Korean children, 2004–2006Article Published on 2006-11-292022-11-01 Journal: Journal of Clinical Virology [Category] Coronavirus, MERS, [키워드] HCoV-NL63 Acute bronchiolitis acute respiratory disease Adenovirus children clinical feature collected Croup described detect excluded found HCoV-NL63 Hospitalized Human IFA Infection influenza A influenza B Korean children MOST MPV nasopharyngeal nasopharyngeal specimen objective parainfluenza PCR assay PCR product positive Prevalence primer reported respiratory tract infection respiratory viruses Result RSV RT-PCR sequenced tested the patient viruses were used [DOI] 10.1016/j.jcv.2006.10.009 PMC 바로가기 [Article Type] Article
Virus-specific RNA and Antibody from Convalescent-phase SARS Patients Discharged from HospitalResearch Published on 2004-10-012022-10-31 Journal: Emerging Infectious Diseases [Category] Coronavirus, [키워드] acute respiratory syndrome analyzed antibody caused collected conjunctival convalescence cross-sectional determined discharged patient ELISA enzyme immunoassay immunofluorescence assay Indirect immunofluorescence assay MOST Novel coronavirus occurred Patient polymerase chain polymerase chain reaction positive Prevalence Research RNA SARS SARS-CoV Seroconversion seroconverted serology seropositive serum serum sample severe specimen Stool tested throat swab Two patient Urine Viral RNA virus was determined [DOI] 10.3201/eid1010.040026 PMC 바로가기 [Article Type] Research