clinical trial – Page 223 – Communicable Diseases Research

Concentration-dependent mortality of chloroquine in overdose

과다복용 시 클로로퀸의 농도 의존적 사망률

Research Article

Published on 2020-07-082022-10-31
Journal: eLife [Category] COVID-19, 말라리아,

Combination treatments with hydroxychloroquine and azithromycin are compatible with the therapeutic induction of anticancer immune responses

하이드록시클로로퀸과 아지스로마이신의 병용 치료는 항암 면역 반응의 치료 유도와 양립 가능합니다.

Article

Published on 2020-07-082022-09-11
Journal: Oncoimmunology [Category] SARS, 바이오마커, 비임상, 신약개발, 임상,

[키워드] administration Affect antibiotic anticancer antimalarial antimalarial drug appear autophagic flux AZI Azithromycin blockade body weight breath Campus Cancer Cancer patients cancers cisplatin clinical trial Combination combination therapy COVID-19 crizotinib curative dose doses Gustave Roussy HCQ Hydroxychloroquine immune immune checkpoint immune response immune responses immunogenic cell death Immunotherapy indicated inducer interfere investigated lung cancer mice not affect oxaliplatin PD-1 preclinical study reduction in regimen SARS-CoV-2 therapeutic treated Treatment Tumor tumor growth utility
[DOI] 10.1080/2162402X.2020.1789284 PMC 바로가기 [Article Type] Article

Small molecule therapeutics for COVID-19: repurposing of inhaled furosemide

Cell Biology

Published on 2020-07-072022-10-28
Journal: PeerJ [Category] COVID-19,

[키워드] “cytokine storm” addition Anti-inflammatory anti-inflammatory activity anti-inflammatory cytokine applicability biologic caused cell line clinical trial clinical utility coronavirus COVID-19 Cytokine storm Cytokines evaluate furosemide Health host inflammatory response hypercytokinemia identify IL-1ra IL-6 IL-8 immuno-inflammatory in silico in vitro Inhaled inhibitor of IL-6 initial Innate immunity involved lethal infection LPS mechanism of action molecular docking morbidity and mortality multiple cytokine novel coronavirus SARS-CoV-2 Pathogenesis pro-inflammatory cytokine pro-inflammatory cytokines promote Safe small molecule stimulated subsequent suppresse therapeutic therapy THP-1 TNF-α Treatment viral infection virus was reduced
[DOI] 10.7717/peerj.9533 PMC 바로가기 [Article Type] Cell Biology

A mechanistic model and therapeutic interventions for COVID-19 involving a RAS-mediated bradykinin storm

Short Report

Published on 2020-07-072022-10-31
Journal: eLife [Category] COVID-19, SARS,

[키워드] ACE ACE2 activate addition addressed Affect affected affecting Analysis analyzed Atypical BALF blood pressure blood vessel bradykinin Brain Bronchoalveolar lavage fluid cause caused Cell changes in China clinical trial clinician collected Combination contribute Control cough COVID-19 COVID-19 patient COVID-19 patients Critical decrease decreased expression degrade develop disease drug effective enzyme expand experiment explain Gene Expression help high temperature Host Human Hyaluronic acid identify increases in individual induce Inflammation life-threatening Lower lung lung cell maintain mechanism Mild molecular mechanism multiple tissue new virus no symptom opposite outcome oxygen uptake Pain Pathogenesis Patient patients with COVID-19 predicted previous study produced provide RAS receptors regulate renin-angiotensin system researcher responsible risk SARS-CoV-2 sequence severe symptom shown Spread storm Symptom Symptoms symptoms of COVID-19 the disease the SARS-CoV-2 virus therapeutic intervention tissue treat treatments for COVID-19 turn vascular dilation vascular permeability virus was increased were used
[DOI] 10.7554/eLife.59177 PMC 바로가기 [Article Type] Short Report

Can artificial intelligence identify effective COVID ‐19 therapies?

News & Views

Published on 2020-07-072022-11-01
Journal: EMBO Molecular Medicine [Category] COVID-19, MERS, SARS,

[키워드] activity administration Antiviral Can Chemical biology clinical trial correlated COVID COVID‐19 disease effective identify liver Medicine Microbiology, Virology & Host Pathogen Interaction Organoid pandemic Patient Placebo‐controlled provide rheumatoid arthritis treat trials
[DOI] 10.15252/emmm.202012817 PMC 바로가기 [Article Type] News & Views

Impact of vitamins A, B, C, D, and E supplementation on improvement and mortality rate in ICU patients with coronavirus-19: a structured summary of a study protocol for a randomized controlled trial

Study Protocol

Published on 2020-07-062022-10-29
Journal: Trials [Category] Coronavirus, SARS,

[키워드] 1:1 Abnormalities absence Ascorbate assigned baseline Biotin block BMI body temperature Chemotherapy clinical clinical trial clinical trials Complete condition control group COVID-19 CRP CT scan definitive diagnosis dissemination Duration element eligible patient ESR evaluate exclusion criteria expected female patient Folic acid Gender HIV Hospitalization Hypothesis ICU ICU patient IL6 Imam Impact IMPROVE include inclusion criteria intensive care unit Intervention invasive Iran kidneys liver lung male mortality rate New nicotinamide Non-invasive number objective organ outcome oxygen saturation pantothenate parallel group participant participated Patient patients patients with COVID-19 PCR per day percentage phosphate Placebo polymerase chain protocol pulmonary involvement randomization Randomized Randomized controlled trial Randomly receive registry renal researcher respiratory Riboflavin Sample size severity significantly sodium SpO2 Study protocol Supplementation Support table Tehran the patient thiamine nitrate TNF-α Treatment Two-arm viral disease Vitamin vitamin A Vitamin B Vitamin C Vitamin D Vitamin E WBC website weight with COVID-19
[DOI] 10.1186/s13063-020-04547-0 PMC 바로가기 [Article Type] Study Protocol

Systematic review of the registered clinical trials for coronavirus disease 2019 (COVID-19)

Review

Published on 2020-07-062022-10-30
Journal: Journal of Translational Medicine [Category] COVID-19, SARS,

[키워드] 2019-nCoV center Characteristics China Chinese Chinese hospitals clinical clinical evidence clinical trial Cochrane Handbook conducted coronavirus disease COVID-19 database drugs evaluated exclusion criteria exploratory trial identify Improving Inclusion Intervention Interventional trial majority median Methodological quality New coronavirus pneumonia observation observational studies observational study outbreak outcome Patient patients performed recommendation recruit Registered Registered clinical trial Registration Research researcher Result Risk of bias Sample size searched selected small sample size statistical Study design subject systematic review the median Treatment Trial trials
[DOI] 10.1186/s12967-020-02442-5 PMC 바로가기 [Article Type] Review

Transcatheter drug delivery through bronchial artery for COVID-19: is it fiction or could it come true?

Hypothesis

Published on 2020-07-062022-10-31
Journal: European Radiology Experimental [Category] COVID-19, SARS,

Frailty and COVID-19: A Systematic Scoping Review

Review

Published on 2020-07-042022-10-30
Journal: Journal of Clinical Medicine [Category] COVID-19,

Mesenchymal Stem Cells: A New Piece in the Puzzle of COVID-19 Treatment

Immunology

Published on 2020-07-032022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS,