clinical trial – Page 224 – Communicable Diseases Research

Insights of Novel Coronavirus (SARS-CoV-2) disease outbreak, management and treatment

Review

Published on 2020-07-032022-10-27
Journal: AIMS Microbiology [Category] COVID-19,

Targeting GM-CSF in COVID-19 Pneumonia: Rationale and Strategies

Immunology

Published on 2020-07-032022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS,

[키워드] administration alveolar macrophage animal model binding blockade blunting cells circulating Clinical improvement clinical trial compassionate use COVID-19 Cytokine release syndrome death described driven by FDA approval GM-CSF healthy controls help Hospitalization hyperinflammation IL-6 Increased Inflammatory cytokine Inflammatory response inflammatory signaling interferon-γ intranasal intravenous dose involved lung damage Macrophage macrophages mavrilimumab mechanical ventilation Mild symptom monoclonal antibodies monoclonal antibody MOST outcomes Oxygenation patients with COVID-19 placebo-controlled trial produced proliferation Prospective provided Randomized rationale receptor Respiratory failure respiratory infections SARS-CoV-2 Severe case severe pneumonia Signaling Strategy syndrome T-cells targeting tested treated Trial while
[DOI] 10.3389/fimmu.2020.01625 PMC 바로가기 [Article Type] Immunology

COVID-19 Coronavirus Vaccine Design Using Reverse Vaccinology and Machine Learning

역백신학 및 기계 학습을 사용한 COVID-19 코로나바이러스 백신 설계

Immunology

Published on 2020-07-032022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 비임상,

[키워드] adhesins Analysis antigenicity applied breath Candidates caused clinical trial complementary Complete conserved contagious contagious disease coronavirus coronavirus vaccine COVID-19 COVID-19 pandemic COVID-19 vaccine COVID-19 vaccine development develop disease effective Epitopes FIVE Host human coronavirus immune responses induce infecting Invasion lack linear B-cell epitope linear B-cell epitopes machine learning membrane MERS MERS-CoV MHC-I MHC-II mild symptoms N protein non-structural protein non-structural protein 3 non-structural proteins NSP Nsp3 NSP8 nucleocapsid predict predicted Protective Protein Proteins proteome reverse vaccinology S protein Safe SARS-CoV SARS-CoV-2 SARS-CoV-2 coronavirus sequence stimulate structural protein T-cell epitopes target tested the S protein the SARS-CoV-2 Vaccine vaccine candidate Vaccine development vaxign vaxign-ML Viral virus was selected
[DOI] 10.3389/fimmu.2020.01581 PMC 바로가기 [Article Type] Immunology

Acupuncture for breathlessness in COVID-19 A protocol for systematic review and meta-analysis

3800

Published on 2020-07-022022-10-30
Journal: Medicine [Category] COVID-19, SARS,

Hydroxychloroquine efficacy and safety in preventing SARS-CoV-2 infection and COVID-19 disease severity during pregnancy (COVID-Preg): a structured summary of a study protocol for a randomised placebo controlled trial

Letter

Published on 2020-07-022022-10-29
Journal: Trials [Category] COVID-19, SARS,

[키워드] 1:1 aetiology agreement allocation Anosmia anticipated Arm ARMS Asymptomatic automatically Barcelona blinded block randomization Cardiac pathology change characterized chills clinical Clinical course clinical trial close contact collected Compound Concomitant conducted confirmed COVID-19 case Contact cough Course COVID-19 COVID-19 disease COVID-19 disease severity CRF criteria delivery determine diarrhoea dissemination double-blind Dyspnoea ECDC Effect Efficacy Efficacy and safety element EudraCT evaluate evaluate the effect Fever FIVE gestation global health HCQ headache history hospital Hospitalization Hydroxychloroquine hypersensitivity inclusion criteria intervention study investigator Liver disease Mild mild symptoms Mortality multicentre nasopharyngeal number objective oropharyngeal swab outcome packaged Pain participant Patient PCR PCR-confirmed Placebo placebo controlled trial placebo-controlled Pregnancy pregnant pregnant women prenatal Prevent Primary outcome progression protocol randomised randomised controlled trial Randomized receive recruited recruitment reducing Registered risk Sample size SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 PCR SARS-CoV-2 viral shedding status stratified study group study participant Study protocol subsequent Symptom symptomatic syndrome Tablet Tolerability Transmission Treatment treatment group Trial Two-arm uterine website women
[DOI] 10.1186/s13063-020-04557-y PMC 바로가기 [Article Type] Letter

The Oxford Royal College of General Practitioners Clinical Informatics Digital Hub: Protocol to Develop Extended COVID-19 Surveillance and Trial Platforms

Protocol

Published on 2020-07-022022-10-31
Journal: JMIR Public Health and Surveillance [Category] COVID-19,

[키워드] accelerate Accessibility acute respiratory syndrome adaptive clinical trials analyses Analysis approaches approval benefit Care clinical clinical trial clinical trials clinical trials as a topic collected college communicable Community contribute coronavirus coronavirus disease COVID-19 data extraction data set data sets Digital disease incidence Disease surveillance dissemination drug effective episode European Extended facilitate facilitated feasibility fixed food General practice general practitioner General practitioners Health Health Service Host Identifier informatics initial International interoperability lockdown medical record systems, computerized Metadata National objective office Older ontologies Oxford pandemic participant partnership Patient care platform positive response Practice primary care Primary Health Care protocol Public Health England public health surveillance recorded Regulatory report Repository Research Result SARS-CoV-2 secure sentinel sentinel surveillance serology severe acute respiratory syndrome coronavirus 2 Statistics Support Surveillance Swab Trial United Kingdom Volume
[DOI] 10.2196/19773 PMC 바로가기 [Article Type] Protocol

Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial

Research article

Published on 2020-07-012022-10-05
Journal: International journal of antimicrobial agents [Category] SARS, 임상,

[키워드] 2019-nCoV absence added Asymptomatic average Azithromycin Chinese clinical trial Confirmed COVID-19 patient controls COVID-19 COVID-19 patient eight end point evaluate the effect French hospital Hydroxychloroquine hydroxychloroquine treatment Inclusion Infection Lower respiratory tract much lower Nasopharyngeal swab negative controls non-randomized Open-label Patient patients Presence protocol receive reduction reported respiratory viral Result SARS-CoV-2 significantly significantly more small sample size Symptom Symptoms treated Treatment untreated patients upper respiratory tract Viral load virus virus elimination was tested
[DOI] 10.1016/j.ijantimicag.2020.105949 [Article Type] Research article

SARS‐CoV‐2 and HIV coinfection: clinical experience from Rhode Island, United States

Short Report

Published on 2020-07-012022-10-31
Journal: Journal of the International AIDS Society [Category] COVID-19, SARS,

[키워드] affected African American age Antiretroviral therapy average Care case sery CD4 center clinical experience Clinical finding clinical trial Coinfection comparable coronavirus 2 coronavirus disease COVID‐19 COVID‐19 symptom COVID‐19 develop diagnosed died eight Emergency use authorization female highlight Hispanic HIV Hospitalized IMPROVE Infectious disease male Miriam outcome pandemic Patient patients with HIV preparedness Prevalence Remdesivir respiratory Result Rhode Island Risk factors SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 the United State United State Viral load with HIV
[DOI] 10.1002/jia2.25573 PMC 바로가기 [Article Type] Short Report

A Scoping Review of Registered Clinical Trials of Cellular Therapy for COVID-19 and a Framework for Accelerated Synthesis of Trial Evidence—FAST Evidence

Review article

Published on 2020-07-012022-10-05
Journal: Transfusion Medicine Reviews [Category] SARS, 임상,

[키워드] accelerated acute respiratory distress syndrome Admission Analysis anticipated appear approval ARDSacute respiratory distress syndrome candidate Cell cells cellular cellular therapy clinical clinical trial clinically complex conducted COVID-19 Critical cumulative detect determine effective Effectiveness enrolment framework heterogeneity ICUIntensive Care Unit identify implementation intensive care intensive care unit Intervention mechanical ventilation Mesenchymal stromal cell Meta-analysis Mortality MSC MSCmesenchymal stromal cell multiple study natural killer NK cells NKnatural killer outcome outcomes Patient predominant Prevent receive reductions in Registered registry Regulatory review Safe Sample size searched similar study stromal cell Study design subject subset Support synthesis therapy treat treatments for COVID-19 Trial while WHO
[DOI] 10.1016/j.tmrv.2020.06.001 [Article Type] Review article

A Scoping Review of Registered Clinical Trials of Convalescent Plasma for COVID-19 and a Framework for Accelerated Synthesis of Trial Evidence (FAST Evidence)

Review article

Published on 2020-07-012022-10-05
Journal: Transfusion Medicine Reviews [Category] SARS, 임상,

[키워드] accelerated acute respiratory distress syndrome Analysis Antibody titer anticipated approval Blood clinical clinical trial clinical trials clinically complicate conducted Control convalescent plasma COVID-19 Critical case detect determine effective sample size Effectiveness Efficacy enrolment expected feasibility framework implementation improvement intensive care investigator majority mechanical ventilation Meta-analysis Mortality operator outcome outcomes Patient Placebo plasma Prevent rates of admission reductions in Registered registry reported review searched similar study Statistical power subjects Support synthesis systematic review tested the WHO treat Treatment Trial
[DOI] 10.1016/j.tmrv.2020.06.005 [Article Type] Review article