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[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect aging alteration approach approaches asymptomatic infection cardiovascular disease cardiovascular diseases caused Clinical outcome Comorbidities Comorbidity complications coronavirus coronavirus disease Coronavirus disease 2019 COVID‐19 COVID‐19 crisis declining Defense diabetes Diabetes Mellitus disease disrupt Disruption Effect elderly elderly patients elevated ER stress febrile illness Health higher risk highest Host host defense host response host responses immune functions immunometabolism immunosenescence IMPROVE individual individuals knowledge management mechanism metabolic processes Mild mitochondrial mitochondrial dysfunction molecular mechanism molecular mechanisms outcome pandemic Patient predisposition promote PROTECT pulmonary immunopathology resistance respiratory Respiratory disease risk SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 severe acute respiratory syndrome Coronavirus severe disease severe respiratory disease suppress Tolerance tolerance mechanism Treatment triggered unfolded protein response Viral viral infection viral replication viruses
[DOI] 10.1111/febs.15613 PMC 바로가기 [Article Type] Review