Antibodies to coronaviruses are higher in older compared with younger adults and binding antibodies are more sensitive than neutralizing antibodies in identifying coronavirus‐associated illnessesResearch Article Published on 2020-03-032022-11-01 Journal: Journal of medical virology [Category] Coronavirus, Fulltext, MERS, [키워드] Adults antibodies antibody assessment binding binding antibody cardiopulmonary disease cause contribute convalescent sera coronavirus correlation evaluated healthy Human Humoral immunity illness illnesses Immunity immunosorbent increase increases in Infection infections monitoring neutralization Neutralization assay Neutralizing antibodies neutralizing antibody occurred Older polymerase chain Prospective Study Protective Reinfection repeated Respiratory illness secretion stimulated strain Strains subject subjects susceptibility virus Virus shedding were measured [DOI] 10.1002/jmv.25715 PMC 바로가기 [Article Type] Research Article
16S rRNA gene sequencing reveals an altered composition of the gut microbiota in chickens infected with a nephropathogenic infectious bronchitis virusArticle Published on 2020-02-262022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] 16S rRNA gene Analysis Biomarker Biotechnology bronchitis cause Chloroplast Clostridia collected contribute Diagnosis disease Enterobacteriaceae Goblet cell Gut gut microbiota Health IBV ileal Infection Infectious Bronchitis Virus information Initially intestinal invading pathogens microbial Microbiology Microbiome microbiota Morphological profile Randomly reveal Sequencing Sequencing analysis significant decrease the Coronaviridae two group villus virus [DOI] 10.1038/s41598-020-60564-8 PMC 바로가기 [Article Type] Article
From SARS to COVID-19: A previously unknown SARS- related coronavirus (SARS-CoV-2) of pandemic potential infecting humans – Call for a One Health approachShort Communication Published on 2020-02-242022-10-28 Journal: One Health [Category] COVID-19, [키워드] acute respiratory disease acute respiratory syndrome approach cause China coronavirus COVID-19 COVID-19 outbreak global public health Health highlighting highly pathogenic Human Impact implementation IMPROVE infecting measure one health pandemic reduce SARS-CoV-2 viruses [DOI] 10.1016/j.onehlt.2020.100124 PMC 바로가기 [Article Type] Short Communication
Swine acute diarrhea syndrome coronavirus-induced apoptosis is caspase- and cyclophilin D- dependentArticle Published on 2020-02-242022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, MERS, [키워드] activated acute diarrhea Apoptosis apoptosis-inducing factor Apoptotic cell death apoptotic pathway association Bax caspase caspase-8 cause Cell characterized cleavage coronavirus cyclosporin A cytochrome cytoplasm diarrhea Evidence extrinsic facilitate host cells IMPROVE in vitro in vivo induce Infection inhibitor intestinal pathological damage intrinsic mechanism mitochondrial MPTP Pathogenesis pathway Pathways Protein reduction in Replication SADS-CoV syndrome treated upregulated Vero E6 viral replication [DOI] 10.1080/22221751.2020.1722758 PMC 바로가기 [Article Type] Article
Systematic Comparison of Two Animal-to-Human Transmitted Human Coronaviruses: SARS-CoV-2 and SARS-CoVCommunication Published on 2020-02-222022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] acute respiratory syndrome cause caused clinical feature clinical manifestations coronavirus Coronaviruses COVID-19 Diagnosis disease Epidemiology genomic genomic comparison global health security Human human coronavirus lung outbreak pathogen pathogenic mechanism pathogenic mechanisms Patient Pneumonia proteomic proteomic comparison reported respiratory epithelium Respiratory tract infections SARS-CoV SARS-CoV-2 severe symptom similarity Symptoms Treatment virus viruses widespread Wuhan [DOI] 10.3390/v12020244 PMC 바로가기 [Article Type] Communication
Emergence of Novel Coronavirus 2019-nCoV: Need for Rapid Vaccine and Biologics DevelopmentReview Published on 2020-02-222022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] 2019-nCoV Anti-viral biopharmaceuticals cause China Collaborative effort coronavirus country develop development diagnostic effective emergence emerging threat health emergency humans Infection Infectious diseases knowledge new virus novel outbreak pathogen Pathogenesis plant plant system question Rapid recent reported researcher reservoirs responsible severe respiratory illness The United States the WHO transient expression Transmissibility Transmission treat Treatment Vaccine Vaccine development virus viruses Wuhan, China zoonoses [DOI] 10.3390/pathogens9020148 PMC 바로가기 [Article Type] Review
Identification of a novel base J binding protein complex involved in RNA polymerase II transcription termination in trypanosomes트리파노솜에서 RNA 중합효소 II 전사 종결에 관여하는 새로운 염기 J 결합 단백질 복합체의 확인Research Article Published on 2020-02-212022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Ablation addition African sleeping sickness Analysis base binding binding domain cause co-IP complex dephosphorylation derepression described DNA downstream genes Epigenetic eukaryotes expand expressed expression Factors gene cluster gene clusters Gene Expression Genome homolog Host Human humans identification identify immune evasion Interaction involved lead leads Leishmania mammalian mass spectrometry mechanism Modification mutant mutants organism Organisms organized phosphatase promoter Protein protein complex Protozoa Reciprocal recruitment regulate regulated Regulatory residue RNA RNA Polymerase II RNA-Seq RNAi RT-PCR shown significantly silent sleeping sickness specific proteins sucrose surface Surface glycoprotein termination thymine Transcription transcription start sites Trypanosoma Trypanosoma brucei Trypanosome upstream variant Variant Surface Glycoprotein Wdr82 yeast [DOI] 10.1371/journal.pgen.1008390 PMC 바로가기 [Article Type] Research Article
Overlapping and discrete aspects of the pathology and pathogenesis of the emerging human pathogenic coronaviruses SARS‐CoV, MERS‐CoV, and 2019‐nCoVReview Published on 2020-02-212022-11-01 Journal: Journal of medical virology [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome cause caused China Committee concern coronavirus Coronaviruses country described Emergency feature highly pathogenic immnopathology immune responses International health regulation introduced knowledge Middle East Novel coronavirus outbreak Pathogenesis pathogenic coronavirus pathology Public public health reported respiratory syndrome coronavirus respiratory tract the disease the WHO virus classification Wuhan [DOI] 10.1002/jmv.25709 PMC 바로가기 [Article Type] Review
Rigidity of the Outer Shell Predicted by a Protein Intrinsic Disorder Model Sheds Light on the COVID-19 (Wuhan-2019-nCoV) InfectivityEditorial Published on 2020-02-192022-10-28 Journal: Biomolecules [Category] COVID-19, SARS, [키워드] acute respiratory syndrome Affect affected affecting cause China computational tool Coronaviral coronavirus country COVID-19 death disorder Epidemic evaluated health emergency Infection infections Infectivity intrinsic laboratory-confirmed LIGHT membrane protein MERS MERS-CoV Middle East Model New coronavirus nucleocapsid protein outbreak predisposition protein intrinsic disorder respiratory syndrome coronavirus rigidity SARS-CoV Shed shell shell disorder Spread the WHO Transmissibility Transmission Viral proteins virulence WHO World Health Organization Wuhan-2019-nCoV [DOI] 10.3390/biom10020331 PMC 바로가기 [Article Type] Editorial
A realistic two-strain model for MERS-CoV infection uncovers the high risk for epidemic propagationResearch Article Published on 2020-02-142022-10-28 Journal: PLoS Neglected Tropical Diseases [Category] Coronavirus, [키워드] absence acute respiratory illness agency anticipated appear basic reproduction number bilinear cause CFR Combination Containment measure disease disease incidence disease spread effective Epidemic Epidemics epidemiological Epidemiology Evolution Fatality rate function high risk highest highlight hotspot incidence Infection information knowledge mathematical measure MERS-CoV MERS-CoV infection Middle East Occurrence outbreak Outbreaks predict predicted public health Region respiratory risk SAT saturated Saudi Arabia strain Super-spreader the epidemic Treatment Vaccine Variability [DOI] 10.1371/journal.pntd.0008065 PMC 바로가기 [Article Type] Research Article