A Truncated Receptor-Binding Domain of MERS-CoV Spike Protein Potently Inhibits MERS-CoV Infection and Induces Strong Neutralizing Antibody Responses: Implication for Developing Therapeutics and VaccinesResearch Article Published on 2013-12-042022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] 293T cells bind binding block caused culture supernatant Developing development Dipeptidyl peptidase 4 domain DPP4 effective eight expressed fused high mortality IgG Fc induce inhibited MERS MERS-CoV MERS-CoV infection mice Middle East neutralize Novel coronavirus Protein purified RBD RBD protein receptor reported residue respiratory infectious disease S-specific antibodies Safe Saudi Arabia spike Spread spread to Strong syndrome therapeutic Therapeutics Vaccine [DOI] 10.1371/journal.pone.0081587 PMC 바로가기 [Article Type] Research Article
A safe and convenient pseudovirus-based inhibition assay to detect neutralizing antibodies and screen for viral entry inhibitors against the novel human coronavirus MERS-CoVMethodology Published on 2013-08-262022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] acute respiratory syndrome Antisera antiviral therapeutics backbone BSL-3 can be used cause Cell coronavirus demonstrated detect Dipeptidyl peptidase-4 disease domain DPP4 effective vaccine entry inhibitors evaluate exhibited expressing full-length fused highly pathogenic HIV Human serum albumin IgG Infection inhibit inhibitor inhibitors luciferase-expressing HIV-1 MERS-CoV MERS-CoV entry MERS-CoV pseudovirus mice Middle East Neutralizing antibodies neutralizing antibody Neutralizing antibody response Novel human coronavirus produced Protein pseudovirus RBD receptor residue respiratory syndrome coronavirus Result Safe significantly Spike protein variety viral entry [DOI] 10.1186/1743-422X-10-266 PMC 바로가기 [Article Type] Methodology
Adjuvant Activity of Sargassum pallidum Polysaccharides against Combined Newcastle Disease, Infectious Bronchitis and Avian Influenza Inactivated VaccinesArticle Published on 2012-11-222022-10-30 Journal: Marine Drugs [Category] Coronavirus, Fulltext, 조류인플루엔자, [키워드] Sargassum pallidum polysaccharide activity adjuvant adjuvanticity Antibody titer bronchitis Combined combined Newcastle disease, infectious bronchitis and avian influenza inactivated vaccines disease dose Effect evaluate immune immune response immunization Inactivated vaccine infectious Influenza investigated lymphocyte polysaccharide proliferation Prophylaxis Safe Sargassum T lymphocytes Vaccine [DOI] 10.3390/md10122648 PMC 바로가기 [Article Type] Article
Sublingual immunization with recombinant adenovirus encoding SARS-CoV spike protein induces systemic and mucosal immunity without redirection of the virus to the brainResearch Published on 2012-09-212022-10-28 Journal: Virology Journal [Category] Coronavirus, MERS, [키워드] addition Adenovirus administration against SARS-CoV airway Antibody Response Antigen Brain CD8 comparable coronavirus effective examined IgA IgA antibody immune response Immunity immunization inactivated viruses indicate induce infect Infection intramuscular intranasal lung mice mucosa mucosal mucosal route Neutralizing olfactory protective immunity protein antigens recombinant recombinant adenovirus Result Safe SARS-CoV SARS-CoV spike protein serum Severe acute respiratory syndrome shown Spike protein Sublingual Sublingual administration T cell T cell response tissues vector virus Virus-like particle [DOI] 10.1186/1743-422X-9-215 PMC 바로가기 [Article Type] Research
Etiology and Clinical Characterization of Respiratory Virus Infections in Adult Patients Attending an Emergency Department in BeijingResearch Article Published on 2012-02-282022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] addressed Adult assay Attending Beijing characterization checked China clinical clinical symptom conducted Department detected determine different dominant effective Emergency epidemiological finding HCoV-229E Health highlight human coronavirus influenza virus métapneumovirus nose parainfluenza pathogen Patient picornavirus polymerase chain positive Prevalence profile real-time RT-PCR reported respiratory respiratory syncytial virus respiratory tract infection respiratory virus Respiratory virus infection respiratory viruses reverse transcription RSV Safe significantly tested therapeutic approach throat swab virus virus virus infection viruses [DOI] 10.1371/journal.pone.0032174 PMC 바로가기 [Article Type] Research Article
Inducible Bronchus-Associated Lymphoid Tissue Elicited by a Protein Cage Nanoparticle Enhances Protection in Mice against Diverse Respiratory VirusesResearch Article Published on 2009-09-232022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] accelerate accelerated antibody production Antigen appear Asymptomatic B cell CAGE cause CD4+ T cell clearance described destruction develop different disparate dose ENhance finding functional Host immune response immune response immune responses Immune-mediated Immunity independent Infection Inflammation influenza viruses inherent less limit lung lung damage Lymphoid tissue mechanisms morbidity nanoparticle novel virus pathogen Primary infection primary viral infection protection protective immune response Protein pulmonary viral recruitment Replication respiratory respiratory virus Safe SARS-coronavirus significant decrease significantly significantly increased specificity survival Treatment Vaccination strategies viral antigens viral clearance virus [DOI] 10.1371/journal.pone.0007142 PMC 바로가기 [Article Type] Research Article
Vaccines to prevent severe acute respiratory syndrome coronavirus-induced diseaseArticle Published on 2007-04-092022-11-01 Journal: Virus research [Category] Coronavirus, MERS, [키워드] 2003 acute respiratory syndrome After animal models approach Coronaviruses described develop diagnose disease DNA vaccines effective Efficacy and safety effort Epidemic genetics Genome heterologous expression humans inactivated viruses led to less other coronaviruses performed Prevent RNA viruses Safe SARS Coronavirus SARS-CoV serotypes Side effects subunit vaccines Trial vaccination Vaccine vaccine candidate vaccine candidates Vaccines virus Virus-like particle VLPs [DOI] 10.1016/j.virusres.2007.01.021 PMC 바로가기 [Article Type] Article
Rapid and sensitive detection of multiple genes from the SARS‐Coronavirus using quantitative RT‐PCR with dual systemsResearch Article Published on 2005-08-242022-11-01 Journal: Journal of medical virology [Category] Coronavirus, [키워드] 2003 ABI accurate acute respiratory syndrome addition Applied Biosystem caused Cell center comparable Control coronavirus cross demonstrated described detect detection detection efficiency Diagnosis evaluated examined Gene human sera in vitro Inc Infection isolate membrane nucleocapsid other coronavirus outbreak PCR prevention primer Prism Quantitative Rapid reagent real‐time quantitative RT‐PCR relative sensitivity RNA Roche RT‐PCR Safe SARS SARS patients SARS‐CoV structural genes SARS2 sensitivity sequence specimen specimens System TaqMan assay transcribed Viral RNA virus viruses [DOI] 10.1002/jmv.20432 PMC 바로가기 [Article Type] Research Article
SARS Vaccine DevelopmentSynopsis Published on 2005-07-012022-10-31 Journal: Emerging Infectious Diseases [Category] Coronavirus, [키워드] acute respiratory syndrome can be used Clinical use conformational coronavirus develop Developing development effective inactivated inducer Infection Neutralizing antibodies Neutralizing epitone neutralizing epitopes Prevent Protein RBD Receptor-binding domain Recombinant protein S protein Safe SARS SARS-CoV SARS-CoV vaccine sequence Spike protein the RBD the receptor-binding domain the S1 subunit Vaccine Vaccines vector [DOI] 10.3201/eid1107.050219 PMC 바로가기 [Article Type] Synopsis
Expanding the frontiers of existing antiviral drugs: Possible effects of HIV-1 protease inhibitors against SARS and avian influenzaArticle Published on 2005-05-122022-11-01 Journal: Journal of Clinical Virology [Category] Coronavirus, Fulltext, 조류인플루엔자, [키워드] acute respiratory syndrome antiretroviral Antiviral antiviral drug Clinical studies computational simulation coronavirus disease docking Effect Evidence HIV-1 protease inhibitor humans imperative in silico in vivo Influenza Influenza virus influenza viruses inhibition assay PI Possible potential benefit potential therapeutic agent protease provided public health RNA-dependent RNA polymerase Safe SARS SARS Coronavirus SARS-CoV subunit suggested therapy these compound Type-A influenza viral disease [DOI] 10.1016/j.jcv.2005.03.005 PMC 바로가기 [Article Type] Article