Comparative systematic review and meta-analysis of reactogenicity, immunogenicity and efficacy of vaccines against SARS-CoV-2Review Article Published on 2021-05-132022-10-30 Journal: NPJ Vaccines [Category] COVID-19, [키워드] Adaptive immunity adverse events Antibody binding BNT162b2 Comparative Efficacy ELISPOT emergence Frequency functional highest Infectious diseases literature review Meta-analysis Mild mRNA vaccine mRNA-1273 NAb neutralizing antibody NHP non-human primate phase reactogenicity reduce response responses SARS-CoV-2 SARS-CoV-2 vaccine selective systematic review T cell trade-off Trial vaccination Vaccine vaccine platform Vaccines variant Viral vector [DOI] 10.1038/s41541-021-00336-1 PMC 바로가기 [Article Type] Review Article
Immunomodulation by the Commensal Microbiome During Immune-Targeted Interventions: Focus on Cancer Immune Checkpoint Inhibitor Therapy and VaccinationReview Published on 2021-05-132024-09-02 Journal: Frontiers in immunology [Category] 대상포진, [키워드] Adaptive immunity Immune checkpoint inhibitors Immuno-oncology Innate immunity Microbiome Vaccines [DOI] 10.3389/fimmu.2021.643255 PMC 바로가기 [Article Type] Review
Identification and characterization of a SARS-CoV-2 specific CD8 + T cell response with immunodominant features면역우세적 특징을 갖는 SARS-CoV-2 특이적 CD8 + T 세포 반응의 식별 및 특성화Article Published on 2021-05-102022-09-12 Journal: Nature Communications [Category] SARS, 변종, 진단, [키워드] Adaptive immunity caused CD8 CD8-positive T cells complexes convalescence COVID-19 pandemic COVID-19 patients Critical cytokine production detectable epitope Epitopes expression feature functional gene expression profile HLA alleles HLA-A identification identify immune response immune responses immunodominant immunodominant epitope immunodominant epitopes immunogenic Infectious diseases inhibiting lack landscape memory Migration NKG2A ORF1 ORF1ab Patient patients patients with COVID-19 response reveal SARS-CoV-2 SARS-CoV-2 epitopes severe disease survival T cell T cell response T cells Viral antigen viral antigens [DOI] 10.1038/s41467-021-22811-y PMC 바로가기 [Article Type] Article
Immune profiling of COVID-19: preliminary findings and implications for the pandemicCOVID-19의 면역 프로파일링: 팬데믹에 대한 예비 연구 결과 및 의미Review Published on 2021-05-012022-09-12 Journal: Journal for immunotherapy of cancer [Category] SARS, 진단, [키워드] acute infection adaptive Adaptive immunity antibody asymptomatic infection baseline cellular change clinical outcomes clinical symptom Course COVID-19 cross-reactive death disease disease severity help host immune system humoral immune Immune profile immune response Immunity implication infected individuals Infection Inflammation Inflammation mediators Innate interact majority other coronavirus outcome pandemic preliminary finding Research response responses SARS-CoV-2 subsequent T cell response understanding uninfected Vaccine development virus [DOI] 10.1136/jitc-2021-002550 PMC 바로가기 [Article Type] Review
Protection against SARS-CoV-2 infection by a mucosal vaccine in rhesus macaques붉은털 원숭이의 점막 백신에 의한 SARS-CoV-2 감염에 대한 보호Research Article Published on 2021-04-282022-09-10 Journal: JCI Insight [Category] MERS, SARS, 진단, 치료기술, [키워드] Adaptive immunity binding boost cellular immunity complementary controls COVID-19 demonstrated detectable dimeric Efficacy elicited IFN-α IgA IL-15 immunization Innate immunity intramuscularly intranasal Lower respiratory tract mucosal multiple dose multiple doses naive controls nasal Nasal cavity neutralizing antibody PROTECT protection Protective protective mechanism protective mechanisms respiratory response rhesus macaque rhesus macaques RNA robust Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine Spike protein spike protein S1 Subunit vaccine subunit vaccines systemically T cell TLR agonists Vaccine Vaccines Viral viral replication virus [DOI] 10.1172/jci.insight.148494 PMC 바로가기 [Article Type] Research Article
Dysregulated Innate and Adaptive Immune Responses Discriminate Disease Severity in COVID-19조절되지 않는 선천 및 적응 면역 반응이 COVID-19의 질병 중증도를 구별합니다Article Published on 2021-04-232022-09-11 Journal: The Journal of Infectious Diseases [Category] SARS, 바이오마커, [키워드] abrogated adaptive Adaptive immunity Analysis Biomarkers Cell Clustering analysis COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 patients Critical Critically ill critically ill patients cytokine cytokine production Cytokines disease disease severity exhaustion markers flow cytometry hepatocyte growth factor highlight highlighting host response Hyperinflammatory immune response immune responses Inflammatory Inflammatory responses Innate innate immune innate immune response innate immune responses Innate immunity interferon interferon-γ interleukin interleukin-17 lymphopenia mononuclear cell performed Peripheral blood Plasma cytokine Potential biomarker potential biomarkers proinflammatory proteomics provide response Result stem cell stem cell factor T-cell exhaustion Variation Whole blood [DOI] 10.1093/infdis/jiab065 PMC 바로가기 [Article Type] Article
A majority of uninfected adults show preexisting antibody reactivity against SARS-CoV-2감염되지 않은 성인의 대다수는 SARS-CoV-2에 대한 기존 항체 반응성을 나타냅니다.Observational Study Published on 2021-04-222022-09-10 Journal: JCI Insight [Category] MERS, SARS, 임상, 진단, 치료법, [키워드] absence Adaptive immunity age and sex antibody cross-reactivity antibody reactivity Antibody testing approach Canada circulating Clinical severity conserved correlated COVID-19 cross-reactivity defined domain Evidence evidence of false false-negative False-positive greater immunology Infant Infants lack majority mapped maternal antibodies maternal antibody Multiplex assay N-terminal domain NTD nucleocapsid occur peptide population level Protein RBD reactivity Receptor-binding domain responses SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine Spike protein Support test results the spike protein threshold thresholds uninfected Viral Viral proteins waned [DOI] 10.1172/jci.insight.146316 PMC 바로가기 [Article Type] Observational Study
Enhanced influenza A H1N1 T cell epitope recognition and cross-reactivity to protein-O-mannosyltransferase 1 in Pandemrix-associated narcolepsy type 1Article Published on 2021-04-162023-06-08 Journal: Nature Communications [Category] Fulltext, 신종인플루엔자, [키워드] Adaptive immunity Inactivated Vaccines Paediatric research sleep disorders [DOI] 10.1038/s41467-021-22637-8 PMC 바로가기 [Article Type] Article
Access to and equitable distribution of COVID-19 vaccine in low-income countriesComment Published on 2021-04-142022-10-30 Journal: NPJ Vaccines [Category] COVID-19, [키워드] access Adaptive immunity country COVID-19 vaccine distribution Epidemiology immunology [DOI] 10.1038/s41541-021-00323-6 PMC 바로가기 [Article Type] Comment
SARS‐CoV‐2‐specific serological and functional T cell immune responses during acute and early COVID‐19 convalescence in solid organ transplant patientsOriginal Article Published on 2021-04-122023-06-15 Journal: American journal of transplantation : official jou [Category] MERS, SARS, [키워드] Adaptive immunity basic (laboratory) research / science clinical research / practice COVID‐19 infection heart transplantation / cardiology infection and infectious agents kidney transplantation / nephrology liver transplantation / hepatology solid organ transplantation T cell biology [DOI] 10.1111/ajt.16570 PMC 바로가기 [Article Type] Original Article