The early start of hemoperfusion decreases the mortality rate among severe COVID-19 patients: A preliminary studyControlled Clinical Trial Published on 2022-04-012023-07-07 Journal: Hemodialysis International. International Symposiu [Category] COVID19(2023년), [키워드] ARDS COVID-19 Cytokine storm hemoperfusin Mortality [DOI] 10.1111/hdi.12982 [Article Type] Controlled Clinical Trial
Lung Response to a Higher Positive End-Expiratory Pressure in Mechanically Ventilated Patients With COVID-19Clinical Trial Published on 2022-04-012022-10-04 Journal: Chest [Category] 임상, [키워드] acute respiratory distress acute respiratory distress syndrome Airway Pressure ARDS Compliance coronavirus disease Coronavirus disease 2019 COVID-19 CT scan decrease defined Endotracheal intubation exceeded Hyperinflation IMPROVE increase in lung lung recruitment mechanical ventilation Oxygenation Patient patients with ARDS PEEP Positive end-expiratory pressure pressure recruitment response Supine position Trial Ventilated ventilatory Volume were measured [DOI] 10.1016/j.chest.2021.10.012 PMC 바로가기 [Article Type] Clinical Trial
Clinical features and major bleeding predictors for 161 fatal cases of COVID-19: A retrospective observational studyObservational Study Published on 2022-04-012022-10-05 Journal: Bosnian Journal of Basic Medical Sciences [Category] 임상, [키워드] Acute kidney injury age ARDS C-reactive protein change Characteristics clinical collected Complication complications correlation COVID-19 CRP D-dimer Diabetes Mellitus died Disseminated intravascular coagulation events feature hemoglobin hemoptysis Hospitalization hypertension In-hospital in-hospital complication in-hospital complications independent predictor INR intensive care International Laboratory laboratory parameter liver LMWH low molecular weight major bleeding male median age myocardial injury non-survivor normalized parameter Patient patients with COVID-19 Platelet predictor proportion regression analysis retrospective Retrospective study risk factor suffered the patient were recorded with COVID-19 [DOI] 10.17305/bjbms.2021.6577 PMC 바로가기 [Article Type] Observational Study
Biotechnological Perspectives to Combat the COVID-19 Pandemic: Precise Diagnostics and Inevitable Vaccine ParadigmsReview Published on 2022-03-312023-06-15 Journal: Cells [Category] MERS, SARS, [키워드] ARDS coronavirus COVID-19 CRISPR detection methods nucleic acid test (NAT) SARS-CoV-2 Vaccine [DOI] 10.3390/cells11071182 PMC 바로가기 [Article Type] Review
SARS-CoV-2 pathogenesis Reviews Published on 2022-03-302022-10-05 Journal: Nature reviews. Microbiology [Category] COVID19(2023년), SARS, 임상, [키워드] acute respiratory distress acute respiratory syndrome alveolar damage ARDS caused Coagulation coronavirus COVID-19 CRISPR Screens develop Endothelium highlight Immune cell immune responses immunopathology infect infected with SARS-CoV-2 Infection Inflammation Inflammatory response life-threatening Lower respiratory tract Mild moderate disease pandemic pathophysiology Pneumonia potential mechanism review SARS-CoV-2 SARS-CoV-2 pathogenesis single-cell syndrome therapeutic intervention upper airways virus replication [DOI] 10.1038/s41579-022-00713-0 [Article Type] Reviews
Repurposing Multiple-Molecule Drugs for COVID-19-Associated Acute Respiratory Distress Syndrome and Non-Viral Acute Respiratory Distress Syndrome via a Systems Biology Approach and a DNN-DTI Model Based on Five Drug Design Specifications5가지 약물 설계 사양을 기반으로 하는 시스템 생물학 접근법 및 DNN-DTI 모델을 통한 COVID-19 관련 급성 호흡곤란 증후군 및 비바이러스성 급성 호흡곤란 증후군에 대한 다분자 약물 용도 변경Article Published on 2022-03-262022-09-11 Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 바이오마커, 신약개발, 유전자 메커니즘, [키워드] acute respiratory distress acute respiratory distress syndrome advance AIC Akaike information criterion approach ARDS Biology Biomarker Biomarkers candidate drug candidate drugs clinical manifestation clinical manifestations convenience coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients COVID-19-associated ARDS criterion database deep neural network drug drug candidate drug design drug target drug-likeness drug-target DTI model Epidemic Epigenetic etiologic mechanism excretion False positive False positives Genetic help host-pathogen RNA-Seq data HPI-GWGEN information Interaction KEGG mechanism Mitigation Model morbidity morbidity and mortality non-viral ARDS Pathogenesis pathogenic pathophysiology pathway Pathways PNP predict predicted Regulation repurposing respiratory respiratory distress RNA sequencing SARS-CoV-2 sensitivity signaling pathway specification syndrome System Systems biology therapeutic option Therapeutic treatment Toxicity [DOI] 10.3390/ijms23073649 PMC 바로가기 [Article Type] Article
STING agonist diABZI induces PANoptosis and DNA mediated acute respiratory distress syndrome (ARDS)STING 효능제 diABZI, PANoptosis 및 DNA 매개 급성 호흡 곤란 증후군(ARDS) 유도Article Published on 2022-03-252022-09-11 Journal: Cell Death & Disease [Category] SARS, 치료법, [키워드] Activation acute lung inflammation acute respiratory distress AIM2 airway amplification amplifying Apoptosis apoptosis induction ARDS CASP8 caspase-3 cell death cGAS cleavage complex contribute Cytokines cytoplasm DDX41 dinucleotide Disruption DNA DNase I double-stranded dsDNA ENhance epithelial extracellular DNA followed by gasdermin D IFN IFN-I IFNAR1 IL-1β IL-6 immune response immune responses induce Infection inflammasomes Inflammation Inflammatory Inflammatory cytokine Inflammatory cytokines Inflammatory response interferon IRF3 low dose lung Lung inflammation mice MLKL necroptosis NET NETosis neutrophilic neutrophilic response NF-kB NF-kB pathway NLRP3 NLRP3 inflammasome nucleotide pathway Phosphorylation priming pro-inflammatory cytokine pro-inflammatory cytokines pyroptosis receptor RIPK3 SARS-COV-2 infection severe ARDS signaling pathway silica smoke stimulator STING subsequent suggested syndrome TBK1 therapeutic strategy TLR9 TNFR1 TNFα Treatment triggered Tumor tumors Type I IFN type I IFN response type I interferon upregulation viral infection ZBP1 [DOI] 10.1038/s41419-022-04664-5 PMC 바로가기 [Article Type] Article
Human placenta-derived amniotic epithelial cells as a new therapeutic hope for COVID-19-associated acute respiratory distress syndrome (ARDS) and systemic inflammationCOVID-19 관련 급성 호흡 곤란 증후군(ARDS) 및 전신 염증에 대한 새로운 치료 희망으로서의 인간 태반 유래 양막 상피 세포Review Published on 2022-03-252022-09-11 Journal: Stem Cell Research & Therapy [Category] SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus aldosterone alveolar fluid clearance amniotic Amniotic membrane angiotensin ARDS cause Cell complications complications of COVID-19 consequence Consequences coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 damaged death drug delivery system Efficacy epithelial cell epithelial cells Epithelial stem cells Exosome Exosomes feature fibrosis hAEC Human immune system immunomodulation immunomodulatory effect immunomodulatory effects mechanism membrane multi-organ failure organ organs Prevent question reaction reduce regeneration regenerative medicine Regulation Renin renin-angiotensin-aldosterone system respiratory distress SARS-CoV-2 serious complication severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 stem cells suggested syndrome systemic inflammation therapeutic Therapeutic approach therapeutic option These cells thrombotic Thrombotic events viral variant [DOI] 10.1186/s13287-022-02794-3 PMC 바로가기 [Article Type] Review
Inhaled Placental Mesenchymal Stromal Cell Secretome from Two- and Three-Dimensional Cell Cultures Promotes Survival and Regeneration in Acute Lung Injury Model in Mice2차원 및 3차원 세포 배양에서 흡입된 태반 중간엽 간질 세포 Secretome은 마우스의 급성 폐 손상 모델에서 생존 및 재생을 촉진합니다Article Published on 2022-03-222022-09-11 Journal: International Journal of Molecular Sciences [Category] SARS, 유전자 메커니즘, [키워드] acute lung injury acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration adult stem cells ALI model ARDS Cell cell spheroids cell-free therapy content coronavirus COVID-19 COVID-19 pandemic cultivation damaged death effective Effectiveness exhibited Extracellular Extracellular vesicles FIBRIN fibroblast healthcare histological immunomodulating in some Inflammatory Inflammatory diseases inhalation Inhaled investigated lung Lung inflammation Lung injury lung surfactant lung tissue Lungs management Measures mice Model morbidity and mortality Mortality Patient placental potential therapy problem proteomic regeneration regenerative respiratory distress Respiratory distress syndrome restored SARS-CoV-2 Secretome severe acute respiratory syndrome Coronavirus severe pneumonia stromal cell surfactant survival syndrome Taking therapeutic tissue regeneration [DOI] 10.3390/ijms23073417 PMC 바로가기 [Article Type] Article
The S1 Subunit of the SARS-CoV-2 Spike Protein Activates Human Monocytes to Produce Cytokines Linked to COVID-19: Relevance to Galectin-3SARS-CoV-2 스파이크 단백질의 S1 서브유닛은 인간 단핵구를 활성화하여 COVID-19와 연결된 사이토카인을 생성합니다: 갈렉틴-3과의 관련성Article Published on 2022-03-222022-09-11 Journal: Frontiers in Immunology [Category] SARS, 변종, [키워드] ACE2 activate Activation acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 ARDS basophil basophils bind caused component coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 CRS cytokine Cytokine release syndrome Cytokines dendritic dendritic cell disease dysregulated Efficacy epithelial cell epithelial cells Evidence facilitate feature fold galectin-3 Health human monocyte human monocytes immune cells Inflammation innate immune innate immune cell Innate immune cells innate immune response Innate immunity lectin Lung injury mechanism MERS Middle East Middle East respiratory syndrome monocyte Monocytes N-terminal domain novel vaccines NTD pandemic persistence pocket Produce Relevance reported respiratory respiratory distress Respiratory distress syndrome responsible S1 subunit S1-NTD S2 subunit SARS-CoV-1 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein severe acute respiratory syndrome Coronavirus shown solid phase spike Spike protein stalk structural homology susceptible individuals syndrome synthesis the S1 subunit the SARS-CoV-2 the spike protein therapeutic interventions Therapeutics Vaccine variants virus while β-Coronaviruses [DOI] 10.3389/fimmu.2022.831763 PMC 바로가기 [Article Type] Article