Cellular immune response – Page 23 – Communicable Diseases Research

Control of SARS-CoV-2 infection after Spike DNA or Spike DNA+Protein co-immunization in rhesus macaques

Research Article

Published on 2021-09-222022-10-29
Journal: PLoS Pathogens [Category] COVID-19, SARS,

Efficacy and breadth of adjuvanted SARS-CoV-2 receptor-binding domain nanoparticle vaccine in macaques

마카크에서 보조제 SARS-CoV-2 수용체 결합 도메인 나노입자 백신의 효능 및 범위

420

Published on 2021-09-212022-09-10
Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 변종, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition adjuvant animals antibody Antibody titers B.1.351 betacoronaviruses breadth CD4+ T cell Cellular immune response cellular response Cellular responses concerning coronavirus Coverage COVID-19 vaccine cross-neutralization activity displaying domain Efficacy eight elicit emergence evaluate ferritin Formulation High-dose highlighting humoral Humoral and cellular immune responses immune responses Immunity lower airway macaque macaques nanoparticle Neutralizing pandemic potency PROTECT Protein QS-21 Rapid receiving Receptor-binding domain reduce Replication respiratory respiratory tract response robust SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein SARS-CoV-2 variant SARS-CoV-2 variants Serum neutralizing antibody Seven severe acute respiratory syndrome Coronavirus Significance Spike protein Support T cell T cell responses Th1 the receptor-binding domain the Sarbecovirus the SARS-CoV-2 two-dose regimen undetectable upper and lower airways vaccination Vaccine Vaccine development variant Viral viral replication VoC VOCs WA1/2020
[DOI] 10.1073/pnas.2106433118 PMC 바로가기 [Article Type] 420

Profiling CD8 + T cell epitopes of COVID-19 convalescents reveals reduced cellular immune responses to SARS-CoV-2 variants

COVID-19 회복기의 CD8 + T 세포 에피토프를 프로파일링하면 SARS-CoV-2 변이체에 대한 감소된 세포 면역 반응이 나타납니다

Article

Published on 2021-09-142022-09-11
Journal: Cell Reports [Category] SARS, 변종,

[키워드] addition alleles binding CD8 CD8+ CD8+ T cells Cellular immune response cellular immunity circulating variants complex conserved contribute convalescent COVID-19 COVID-19 patient COVID-19 patients crystal structure delta variant determine disease severity epitope epitope peptide Epitopes HLA HLA-A human coronaviruses identify Immunity K417 mutated Mutation new SARS-CoV-2 patients peptides Profiling reduce reduced reveal SARS-CoV-2 SARS-CoV-2 epitope SARS-CoV-2 epitopes SARS-CoV-2 variant SARS-CoV-2 variants severity of COVID-19 significantly Spike protein T cell T cell epitope T cell epitopes T cell response T cell responses T cells the disease the spike protein Transmissibility variants
[DOI] 10.1016/j.celrep.2021.109708 PMC 바로가기 [Article Type] Article

GENERATING RESPONSES IMMUNE IN CELLULAR AND HUMORAL TREATMENT WITH EPITOPE SPIKE, EPITOPE ENVELOPE PROTEIN, AND EPITOPE MEMBRANE PROTEIN SARS-COV-2, HONEY, SAUSSUREA LAPPA , AND NIGELLA SATIVA

Article

Published on 2021-09-012022-10-27
Journal: African Journal of Infectious Diseases [Category] COVID-19,

GENERATING RESPONSES IMMUNE IN CELLULAR AND HUMORAL TREATMENT WITH EPITOPE SPIKE, EPITOPE ENVELOPE PROTEIN, AND EPITOPE MEMBRANE PROTEIN SARS-COV-2, HONEY, SAUSSUREA LAPPA , AND NIGELLA SATIVA

에피토프 스파이크, 에피토프 봉투 단백질 및 에피토프 막 단백질 SARS-COV-2, Honey, Saussurea Lappa 및 Nigella Sativa로 세포 및 체액 처리에서 면역을 생성합니다.

Article

Published on 2021-09-012022-09-10
Journal: African Journal of Infectious Diseases [Category] 비임상,

Profile of humoral and cellular immune responses to single doses of BNT162b2 or ChAdOx1 nCoV-19 vaccines in residents and staff within residential care homes (VIVALDI): an observational study

Observational Study

Published on 2021-09-012022-10-05
Journal: The Lancet. Healthy longevity [Category] SARS, 임상,

[키워드] ACE2 binding Adaptive immune response age All participant antibody Antibody Response Antibody titre antibody titres B.1.1.7 B.1.351 B.1.351 variant blood sample BNT162b2 Care Cellular immune response cellular response ChAdOx1 nCoV-19 ChAdOx1 nCoV-19 vaccine Cohort collected correlated correlation country Coverage COVID-19 COVID-19 mortality COVID-19 vaccination COVID-19 vaccine defined Department Evidence extended interval first dose history humoral IgG antibody immune responses immunoassay Impact independent Infection infection with SARS-CoV-2 Interaction IQR kinetic magnitude median median age of BNT162b2 Older P.1 variant P.1 variants participant Participants peptide positive pre-vaccination profile resident response SARS-COV-2 infection SARS-CoV-2 strain second dose serological evidence significantly lower single dose Spike protein spike-specific IgG T-cell Response tested titre vaccination Vaccine vaccine dose variant variants of SARS-CoV-2 were assessed were excluded
[DOI] 10.1016/S2666-7568(21)00168-9 PMC 바로가기 [Article Type] Observational Study

COVID-19 Subunit Vaccine with a Combination of TLR1/2 and TLR3 Agonists Induces Robust and Protective Immunity

Article

Published on 2021-08-272022-10-28
Journal: Vaccines [Category] COVID-19,

[키워드] ACE2 acute respiratory syndrome adjuvant adjuvants agonist angiotensin-converting enzyme 2 antibody Cell Cell-mediated immunity Cellular immune response cellular immune responses Combination coronavirus COVID-19 COVID-19 pandemic COVID-19 vaccine Critical Diseases domain effective Efficacy elicited ELISA assays ENhance ferret model Health humoral IFN-γ-producing T cell IFN-γ immune responses magnitude mucosal immunity NAb nasal neutralizing antibody producing promote protective immunity RBD resulting robust SARS-CoV-2 SARS-CoV-2 antigen stimulated subunit Subunit vaccine TLR agonist TLR agonists TLR3 Toll-like receptor Vaccine vaccine platform Viral load
[DOI] 10.3390/vaccines9090957 PMC 바로가기 [Article Type] Article

Two-Step In Vitro Model to Evaluate the Cellular Immune Response to SARS-CoV-2

Article

Published on 2021-08-262022-10-31
Journal: Cells [Category] COVID-19, MERS, SARS,

Comparative kinetics of SARS-CoV-2 anti-spike protein RBD IgGs and neutralizing antibodies in convalescent and naïve recipients of the BNT162b2 mRNA vaccine versus COVID-19 patients

SARS-COV-2 항-스파이크 단백질 RBD IgG의 비교 동역학 및 BNT162B2 mRNA 백신 대 COVID-19 환자의 회복기 및 순진한 수용자에서 중화 항체의 비교 동역학

Comparative Study

Published on 2021-08-232022-09-01
Journal: BMC Medicine [Category] MERS, SARS, 진단,

[키워드] Abstract Anti-S-RBD IgGs Anti-spike Antibody titer Antibody titers Antigen BNT162b2 BNT162b2 mRNA BNT162b2 mRNA vaccine BNT162b2 vaccine causative agent caused Cellular immune response clone Cohort Comparative contribute convalescent coronavirus COVID-19 COVID-19 patient COVID-19 recovered patient COVID-19 recovered patients dose global pandemic healthy Hospitalized hospitalized patient hospitalized patients humoral Humoral and cellular immune responses IgG IgGs immune immune response immune responses Immunity induce investigated moderate moderate disease moderate or severe disease mononuclear cells NAb NAbs naïve natural infection Neutralizing antibodies neutralizing antibody offer participant Peripheral blood Peripheral blood mononuclear cells priming priming vaccination promote Protein RBD IgG RBD IgGs recipient recipients response Result robust SARS-CoV-2 serum severe COVID-19 severe disease significantly higher supplementary material Support T cell titers Trigger triggers vaccinated individual vaccinated individuals vaccination vaccination efficacy Vaccine viral infection virus infection were measured
[DOI] 10.1186/s12916-021-02090-6 PMC 바로가기 [Article Type] Comparative Study

Health care worker seromonitoring reveals complex relationships between common coronavirus antibodies and COVID-19 symptom duration

의료 종사자 혈청 모니터링은 일반적인 코로나 바이러스 항체와 COVID-19 증상 기간 사이의 복잡한 관계를 보여줍니다

Research Article

Published on 2021-08-232022-09-10
Journal: JCI Insight [Category] MERS, SARS, 유전자 메커니즘, 진단,