Investigating the binding affinity, interaction, and structure-activity-relationship of 76 prescription antiviral drugs targeting RdRp and Mpro of SARS-CoV-2SARS-COV-2의 RDRP 및 MPRO를 대상으로 76 처방 항 바이러스 약물의 결합 친화력, 상호 작용 및 구조-활성-관련을 조사Article Published on 2021-10-012022-08-31 Journal: Journal of biomolecular structure & dynamics [Category] MERS, SARS, 치료제, [키워드] active site active sites antiviral drug antiviral drugs applied binding affinity binding energy binding free energy Cobicistat complex contagious coronavirus Coronavirus replication daclatasvir docking drug drugs Ebola effective enzyme free energy generate HCV hepatitis C hepatitis C virus HIV Human Human immunodeficiency virus immunodeficiency virus in vitro in vivo Interaction MM/PBSA molecular molecular docking molecular dynamics MPro outbreak performed Precision predict Principal component principal component analysis protease protein-drug complex protein-drug complexes proteolysis Quantitative quantitative structure-activity relationship. raltegravir RdRP receptor proteins replicase polyproteins researcher RNA RNA dependent RNA polymerase RNA polymerase RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 virus selected selected drug selected drugs Simeprevir strong interaction structure activity relationship the binding affinity utility virus [DOI] 10.1080/07391102.2020.1796804 PMC 바로가기 [Article Type] Article
Pooled SARS-CoV-2 antigen tests in asymptomatic children and their caregivers: Screening for SARS-CoV-2 in a pediatric emergency department무증상 아동 및 보호자를 대상으로 한 SARS-CoV-2 항원 통합 검사: 소아 응급실에서 SARS-CoV-2 선별 검사Article Published on 2021-10-012022-09-11 Journal: American journal of infection control [Category] SARS, 치료기술, [키워드] Admission Asymptomatic Chain Reaction Child children comparable contagious COVID-19 Critical Ct values effective evaluated extraction buffer False negative hospital Hospital infection identify individual individuals infectious Lateral Lateral flow test medium Mid-turbinate. nasopharyngeal swabs Oropharyngeal Outbreaks P-value PCR PCR swab PCR testing pediatric performed polymerase chain polymerase chain reaction Prevent Result SARS-CoV-2 SARS-CoV-2 antigen Screening Sensitivity and specificity significantly single-center study study period Swab swabbing Turbinate Universal was performed were used [DOI] 10.1016/j.ajic.2021.07.009 PMC 바로가기 [Article Type] Article
Identification of a potential SARS-CoV2 inhibitor via molecular dynamics simulations and amino acid decomposition analysisArticle Published on 2021-10-012022-10-04 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 신약개발, [키워드] Amino acid Analysis binding binding interaction complexes Compound conserved Contact contagious COVID-19 docking results drug effort enzyme Glu166 H-bond interaction Hydrogen bond hydrophobic identification identify in silico in silico hit inhibitor inhibitors Interaction lack less main protease MD simulation molecular molecular docking molecular dynamics Molecular dynamics simulation MPro pathogen physicochemical property provided quantum relative residue SARS-CoV2 SARS-CoV2 main protease stability therapeutic drug torsional Vaccine [DOI] 10.1080/07391102.2020.1797536 PMC 바로가기 [Article Type] Article
Biological Risk in Italian Prisons: From the COVID-19 Management to the Development of a Standardized Model for Emergency ResponseArticle Published on 2021-10-012022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, SARS, [키워드] addition administration adopted approved Biological biological risk communicable diseases contagious contingency plan COVID-19 COVID-19 outbreak COVID-19 pandemic Critical Deceased development disease draft Emergency Epidemics epidemiological feature General population handling Health highlight indoor facilities information International Italian Local measure Model National National Health Service Outbreaks prison prison system public health recommendation resource respond response service sick summer WHO’ [DOI] 10.3390/ijerph181910353 PMC 바로가기 [Article Type] Article
Are doctors protected enough during COVID-19 in South Asia?Research Published on 2021-09-302022-10-31 Journal: Global Health Research and Policy [Category] COVID-19, [키워드] acute respiratory syndrome affected Afghanistan age agency arising Asia available data Care Characteristics Complication conducted contagious coronavirus country COVID-19 COVID-19 pandemic cross-sectional death deaths died Future General population Health high risk highest India Infection information internal Iran management Medicine Mortality mortality rate multivariate logistic regression pandemic performed Personal protective equipment physician Practitioner recorded Region reported Result SARS-CoV-2 selected Sex shown South surgical virus website [DOI] 10.1186/s41256-021-00219-x PMC 바로가기 [Article Type] Research
Vitamin D and COVID-19: An Overview of Recent Evidence비타민 D와 코로나19: 최근 증거 개요Review Published on 2021-09-292022-09-10 Journal: International Journal of Molecular Sciences [Category] SARS, 변종, [키워드] acute respiratory syndrome adaptive immune system benefit Consensus contagious contributing to coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 dysfunction Effect effective Effects global pandemic Host Immunity immunomodulatory effect immunomodulatory effects Infection innate and adaptive immune system lead Medical research modulating Multiorgan Novel coronavirus outbreak poor prognosis prevention of COVID-19 priority progressed recent reported Research respiratory resulting review SARS-CoV-2 SARS-COV-2 infection the disease Treatment treatment of COVID-19 variant virus Vitamin D Vitamin D supplementation while [DOI] 10.3390/ijms221910559 PMC 바로가기 [Article Type] Review
Perception of Parents Towards COVID-19 Vaccine for Children in Saudi PopulationFamily/General Practice Published on 2021-09-282022-10-31 Journal: Cureus [Category] COVID-19, [키워드] acceptability addition age approved caused children clinics collected complications contagious COVID-19 COVID-19 infection COVID-19 vaccine cross-sectional demographics disease Evidence Factors female Gender group healthcare include information lack likelihood majority male offer Older pandemic parent parental parents participant pediatric Perception Population primary care question questionnaire Respiratory Coronavirus Result SARS-CoV-2 Saudi Arabia Seasonal influenza significantly Spread statistically significant the disease the vaccine vaccinate vaccination Vaccine [DOI] 10.7759/cureus.18342 PMC 바로가기 [Article Type] Family/General Practice
A Review on Current COVID-19 Vaccines and Evaluation of Particulate Vaccine Delivery SystemsReview Published on 2021-09-272022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] accelerate acute respiratory syndrome Administered administration approved benefit Compliance contagious coronavirus Coronavirus-2 country COVID COVID-19 current Defense delivery develop died dosage elicit form forms Immunity immunize limitation Microparticle mucosal oral particulate vaccine pandemic Particulate Patient platform preserved public health reported review Saliva SARS-CoV-2 Spread System temperature transported vaccinate vaccination Vaccine Vaccines virus Wuhan, China [DOI] 10.3390/vaccines9101086 PMC 바로가기 [Article Type] Review
Telepsychiatry to Provide Mental Health Support to Healthcare Professionals during the COVID-19 Crisis: A Cross-Sectional Survey among 321 Healthcare Professionals in FranceArticle Published on 2021-09-272022-10-29 Journal: International Journal of Environmental Research an [Category] Coronavirus, SARS, [키워드] approach Care clinical setting communicable contagious COVID-19 COVID-19 pandemic COVID-19 patient cross-sectional disease France healthcare healthcare professionals healthcare worker involved less management mental health multicenter Pandemics professional questionnaire receiving response Support survey Symptoms Telemedicine telepsychiatry usual care women [DOI] 10.3390/ijerph181910146 PMC 바로가기 [Article Type] Article
The impact of prioritisation and dosing intervals on the effects of COVID-19 vaccination in Europe: an agent-based cohort modelArticle Published on 2021-09-222022-10-04 Journal: Scientific Reports [Category] 임상, [키워드] baseline Cohort contagious COVID-19 COVID-19 infections COVID-19 vaccination Diseases dose dosing interval Effect Efficacy Europe European expected Health Hospital admissions hospitalisations infections Infectious diseases input interval mass vaccination Moderna Mortality Oxford-AstraZeneca parameter Pfizer/BioNTech phase 3 trial Population Prioritising public health reduce reduce mortality reduced reducing mortality vaccination Vaccination strategy Vaccine vaccine availability Vaccines viral infection [DOI] 10.1038/s41598-021-98216-0 PMC 바로가기 [Article Type] Article