Impact of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers on the Inflammatory Response and Viral Clearance in COVID-19 PatientsCardiovascular Medicine Published on 2021-08-192022-10-31 Journal: Frontiers in Cardiovascular Medicine [Category] COVID-19, [키워드] ACE inhibitor ACEIs angiotensin angiotensin receptor blocker angiotensin-converting enzyme inhibitor Antiviral treatment ARB ARBs assigned association blocker confounders control group coronavirus disease COVID-19 COVID-19 mortality current decrease Decreased elevated evaluate Evidence Hospitalization hypertension IL-10 IL-1β IL-6 IL-8 Impact Inflammatory response introduced Lymphocyte count medication multicenter Patient patients plasma proinflammatory cytokines Propensity score response retrospective cohort study TNF-α Treatment viral clearance viral shedding withdrawn [DOI] 10.3389/fcvm.2021.710946 PMC 바로가기 [Article Type] Cardiovascular Medicine
Temporal trends of COVID-19 mortality and hospitalisation rates: an observational cohort study from the US Department of Veterans AffairsObservational Study Published on 2021-08-162022-10-05 Journal: BMJ Open [Category] SARS, 임상, [키워드] 30-Day mortality 30-day mortality rate accounted Affair affected Analysis change changes changes in Characteristics cohort study contributed COVID-19 COVID-19 mortality COVID-19 testing Department dropped Epidemiology general medicine (see internal medicine) Health hospital hospitalisation hospitalised individual individuals infected with COVID-19 Observational cohort study occupancy rate Population positive COVID-19 positive individuals suggested Temporal veteran with COVID-19 [DOI] 10.1136/bmjopen-2020-047369 PMC 바로가기 [Article Type] Observational Study
Risk of COVID-19 death in cancer patients: an analysis from Guy’s Cancer Centre and King’s College Hospital in LondonArticle Published on 2021-08-162022-10-04 Journal: British Journal of Cancer [Category] MERS, SARS, 유전자 메커니즘, 치료법, [키워드] 95% confidence interval accounted acute respiratory syndrome Analysis Asian C-reactive protein (CRP Cancer cancer diagnosis cancer patient Cancer patients Characteristics clinical decision college Coronavirus-2 COVID-19 COVID-19 mortality COVID-19-related death Cox proportional hazard CRP dataset death Diagnosis died Dyspnoea Evidence Factor finding Follow-up Haematological cancer haematological malignancy identify increased mortality increased risk London male Mortality oncology Patient patients died positive raised Result Risk factors SARS-CoV-2 severe COVID-19 Sex Swab Translational research was performed was used with COVID-19 [DOI] 10.1038/s41416-021-01500-z PMC 바로가기 [Article Type] Article
The Impact of Structural Inequities on Older Asian Americans During COVID-19Public Health Published on 2021-08-162022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS, [키워드] aging American Americans approach Asian Asian Americans Care Community contribute coronavirus COVID-19 COVID-19 mortality COVID-19 testing eligible greater Health highlight Impact IMPROVE Inclusion intersectionality Older Older adults pandemic Perspective populations prevented racism receiving Region Research rising risk social determinant subpopulation Transmission vaccination [DOI] 10.3389/fpubh.2021.690014 PMC 바로가기 [Article Type] Public Health
Association of Sickle Cell Trait with Risk and Mortality of COVID-19: Results from the United Kingdom BiobankShort Report Published on 2021-08-152022-10-28 Journal: The American Journal of Tropical Medicine and Hygi [Category] COVID-19, MERS, [키워드] 95% CI 95% confidence interval Biobank black carrier confirmation coronavirus disease COVID-19 COVID-19 infection COVID-19 mortality diabete hemoglobin higher risk immune response increased risk individual individuals infection rate Mortality Mutation Odds ratio Result SCT Sickle sickle cell trait significantly higher tested United Kingdom [DOI] 10.4269/ajtmh.20-1657 PMC 바로가기 [Article Type] Short Report
Severe Lymphopenia as a Predictor of COVID-19 Mortality in Immunosuppressed PatientsArticle Published on 2021-08-152022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] acute respiratory distress Admission age analysed ARDS baseline Clinical data Coronavirus disease 2019 COVID-19 COVID-19 mortality diabetes Factor high mortality high mortality rate hospital hospitalised hypertension Immunocompromised Immunosuppressed Immunosuppression independent kidney Liver disease lung lymphopenia Mortality mortality rate mortality risk neurological Patient patients patients with COVID-19 Pneumonia Ratio remained severe lymphopenia study period subjects syndrome with COVID-19 [DOI] 10.3390/jcm10163595 PMC 바로가기 [Article Type] Article
A machine learning approach identifies 5-ASA and ulcerative colitis as being linked with higher COVID-19 mortality in patients with IBDArticle Published on 2021-08-132022-10-04 Journal: Scientific Reports [Category] MERS, 유전자 메커니즘, [키워드] Accuracy age analyses Analysis approach association available data Bacterial infection bowel Case report Characteristics chronic inflammation circumvent comprehensive analysis Computer science condition conditions covariate covariates COVID-19 COVID-19 mortality Crohn's disease Crohn’s disease database Deceased demographic factor detect disease Factor Features gastrointestinal tract Gender generate Generation Health higher risk Hospitalized IBD identify immunosuppressants infections Inference information International lack machine learning approach male management medication MONITOR Mortality number of comorbidity outcome outcomes Patient patient data patients predict Prognosis random reported Repository reveal severity smoking Treatment ulcerative colitis [DOI] 10.1038/s41598-021-95919-2 PMC 바로가기 [Article Type] Article
Cytokine Storms in the Course of COVID-19 and Haemophagocytic Lymphohistiocytosis in Pregnant and Postpartum WomenReview Published on 2021-08-132022-10-28 Journal: Biomolecules [Category] COVID-19, MERS, [키워드] acute respiratory syndrome Analysis Antibiotic therapy Autoimmune reaction coronavirus Course COVID-19 COVID-19 mortality criteria cytokine production Cytokine storm death described diagnose disorder Fever growth haemophagocytic lymphohistiocytosis Hepatitis HLH immunosuppressive include induce Infection Interaction lymphohistiocytosis Patient patient mortality Postpartum postpartum period predictors Pregnancy pregnant pregnant women presenting puerperal Pulmonary infection reduce risk SARS-CoV-2 SARS-COV-2 infection severe COVID-19 similarity storm Support Ventilation women [DOI] 10.3390/biom11081202 PMC 바로가기 [Article Type] Review
DAMPening COVID-19 Severity by Attenuating Danger Signals위험 신호를 감쇠하여 COVID-19 심각도 완화Review Published on 2021-08-122022-09-11 Journal: Frontiers in Immunology [Category] MERS, 변종, 진단, [키워드] absence activate adenosine age-dependent effects contributing to COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 mortality COVID-19 severity cytokine Cytokine storm Cytokines DAMP DAMPs danger-associated molecular patterns death decrease develop differentially expressed effective Effects elevated enhancement explain female groups higher risk in some individuals Inflammation inhibit lead males mandatory molecular pattern Mortality multi-organ failure multiple organ failure NF-κB obese Organ failure pathway Pattern recognition Pattern recognition receptors Prevent proinflammatory molecule proinflammatory molecules Regulation SARS-CoV-2 mutant SARS-CoV2 severity of COVID-19 Side effects signal Signaling susceptible individual TLR TLRs Toll-like receptor Toll-like receptors Vaccine weight with COVID-19 [DOI] 10.3389/fimmu.2021.720192 PMC 바로가기 [Article Type] Review
Comparing the COVID-19 pandemic in space and over time in Europe, using numbers of deaths, crude rates and adjusted mortality trend ratiosArticle Published on 2021-08-122022-10-29 Journal: Scientific Reports [Category] COVID-19, MERS, SARS, [키워드] 95% confidence interval absence accounted accounting adjusted age applied calculate calculated country COVID-19 COVID-19 mortality COVID-19 pandemic cumulative mortality Czech Republic death deaths disease Diseases distribution Efficacy Europe European country European population evaluate expected expected mortality First wave Health highest Hungary Luxembourg Medical research MONITOR Mortality mortality data mortality rate mortality rates pandemic Poland Population Ratio reducing selected Sex Slovakia trend undetectable United Kingdom was used World Health Organisation [DOI] 10.1038/s41598-021-95658-4 PMC 바로가기 [Article Type] Article