Dynamically-Driven Enhancement of the Catalytic Machinery of the SARS 3C-Like Protease by the S284-T285-I286/A Mutations on the Extra DomainResearch Article Published on 2014-07-182022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] 3CL 3CLpro Ala Alter appear catalytic catalytic dyad component conducted correlated correlation Correlation analysis Critical dimeric disrupting domain domains Effects ENhance enhancement enzyme inactivated inactive include mechanisms molecular MOST mutant Mutation opposite Perturbation protease reduction replaced reported residue residues resulting reveal significantly specific inhibitor stability Trigger Volume while wild-type [DOI] 10.1371/journal.pone.0101941 PMC 바로가기 [Article Type] Research Article
The Murine Coronavirus Hemagglutinin-esterase Receptor-binding Site: A Major Shift in Ligand Specificity through Modest Changes in ArchitectureResearch Article Published on 2012-01-262022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] absence architecture Author Bacteria Betacoronavirus binding binding site cell tropism change changed changes in complex consequence coronavirus Coronaviruses domain domains Evolution example Factor glycan glycoprotein Hemagglutinin-esterase Interaction Ligand Lineage living cell Major MHV modifications MOST mouse hepatitis virus murine organ Pathogenesis Protein Protozoa receptor resolved shift sialic acid specificity sugar Topology vertebrates virion virus [DOI] 10.1371/journal.ppat.1002492 PMC 바로가기 [Article Type] Research Article