Highly Thermotolerant SARS-CoV-2 Vaccine Elicits Neutralising Antibodies against Delta and Omicron in Mice고온 내성 SARS-CoV-2 백신은 마우스에서 델타 및 오미크론에 대한 중화 항체를 유도합니다Article Published on 2022-04-132022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] AlphaFold antibody average biomolecular modelling Combination community transmission COVID-19 COVID-19 infection COVID-19 infections D614G mutation Delta derivative domain Efficacy elicit epitope Epitopes help human clinical trial IMPROVE in silico inaccessible mice monomeric neutralisation neutralise omicron phase Prevent Receptor-binding domain Receptor-binding domain (RBD) reduction reduction in responses against risk SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Thermotolerant thermotolerant vaccine titre trimeric unmet need Vaccine vaccine equity vaccine matching variants variants of concern variants of concern (VOC) VoC [DOI] 10.3390/v14040800 PMC 바로가기 [Article Type] Article
Hybrid Proteins with Short Conformational Epitopes of the Receptor-Binding Domain of SARS-CoV-2 Spike Protein Promote Production of Virus-Neutralizing Antibodies When Used for ImmunizationArticle Published on 2022-04-082023-07-01 Journal: Biochemistry. Biokhimiia [Category] COVID19(2023년), SARS, [키워드] Aldolase epitope epitope vaccine RBD RBM S protein SARS-CoV-2 [DOI] 10.1134/S0006297922040022 PMC 바로가기 [Article Type] Article
CHARM: COVID-19 Health Action Response for Marines-Association of antigen-specific interferon-gamma and IL2 responses with asymptomatic and symptomatic infections after a positive qPCR SARS-CoV-2 testCHARM: qPCR SARS-CoV-2 테스트 양성 후 무증상 및 증상 감염에 대한 항원 특이적 인터페론-감마 및 IL2 반응의 해병을 위한 COVID-19 건강 조치 대응Article Published on 2022-04-072022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 진단, 치료법, [키워드] Action All participants Asymptomatic Asymptomatic cases Cell mediated immunity class correlated COVID-19 COVID-19 symptoms COVID-19 vaccine COVID-19 vaccines dropped enrolled Enrollment epitope Epitopes Follow-up frequencies Frequency IFN-γ IFN-γ response IFN-γ responses IL2 immune response include Infection membrane N and M N and S proteins N protein nucleocapsid occurred participant Participants peaked peptide peptide pool peptides positive Post-infection predicted Protein Proteins qPCR qPCR test Responder response responses S proteins S, N and M proteins SARS-CoV-2 SARS-CoV-2 antigens SARS-COV-2 infection SARS-CoV-2 test significantly Study participants subjects Support symptomatic symptomatic and asymptomatic symptomatic infection symptomatic participants T cell T cell response T cell responses tested the N protein These data were measured with COVID-19 [DOI] 10.1371/journal.pone.0266691 PMC 바로가기 [Article Type] Article
Potential Immunogenic Activity of Computationally Designed mRNA- and Peptide-Based Prophylactic Vaccines against MERS, SARS-CoV, and SARS-CoV-2: A Reverse Vaccinology ApproachMERS, SARS-CoV 및 SARS-CoV-2에 대한 계산적으로 설계된 mRNA 및 펩티드 기반 예방 백신의 잠재적 면역원 활성: 역백신학 접근Article Published on 2022-04-062022-09-11 Journal: Molecules [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] 3D structure activity acute respiratory syndrome coronavirus antiviral therapeutics B-cells binding coronavirus Coronavirus-2 Coronaviruses cross-protective CTL CTLs cytotoxic cytotoxic T lymphocytes develop effective Efficacy epitope Epitope-based vaccine Epitopes evaluated followed by HCoVs helper highly pathogenic HTL epitope HTL epitopes HTLs human coronavirus human coronaviruses humans Immune simulation immunogenic immunogenic activity imperative lethality MERS MERS-CoV Middle East Middle East respiratory syndrome Coronavirus molecular docking mRNA mRNA-based offer pandemic pathogenic coronaviruses peptide Potential predicted processed Prophylactic prophylactic vaccine. proteomic RBDs receptor-binding domains respiratory respiratory syndrome coronavirus SARS-CoV SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 similarity the receptor-binding domain these viruses TLR4 Vaccine Vaccine design viruses [DOI] 10.3390/molecules27072375 PMC 바로가기 [Article Type] Article
A potent human monoclonal antibody with pan-neutralizing activities directly dislocates S trimer of SARS-CoV-2 through binding both up and down forms of RBD Research Published on 2022-04-052022-10-05 Journal: Signal Transduction and Targeted Therapy [Category] COVID19(2023년), SARS, 변종, [키워드] activity acute respiratory syndrome approved B.1.617.2 binding caused circulating Clinical use coronavirus COVID-19 cryo-EM demonstrated Efficacy epitope form global pandemic Human monoclonal antibody in vitro in vivo mAb mAbs Microscopy molecular basis Mutation neutralize neutralizing monoclonal antibody novel coronavirus disease Prevent RBD reduced S trimer SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 variant the receptor-binding domain treat unique Vaccine variant VOCs wild-type [DOI] 10.1038/s41392-022-00954-8 [Article Type] Research
Determinants of Immune Response to Anti-SARS-CoV-2 mRNA Vaccines in Kidney Transplant Recipients: A Prospective Cohort Study신장 이식 수혜자의 Anti-SARS-CoV-2 mRNA 백신에 대한 면역 반응의 결정 요인: 전향적 코호트 연구Article Published on 2022-04-012022-09-12 Journal: Transplantation [Category] COVID19(2023년), SARS, 임상, 진단, [키워드] 95% confidence interval acute respiratory syndrome affecting analyzed antibody contrary coronavirus coronavirus disease Cutoff depleting determinant Effectiveness epitope evaluated exhibited Factor humoral immune response independent infected with SARS-CoV-2 interferon gamma kidney transplant recipient mRNA mRNA vaccines mycophenolate Odds ratio Patient Prospective prospective cohort study response S1 and S2 SARS-CoV-2 sensitivity Seroconversion shown significantly more Specific T-cell response specificity Spike protein subset subunit sustained tested the interferon therapy Transplant vaccination Vaccine [DOI] 10.1097/TP.0000000000004044 PMC 바로가기 [Article Type] Article
Recombinant VLPs empower RBM peptides showing no immunogenicity in native SARS-COV-2 protein to elicit a robust neutralizing antibody response재조합 VLP는 천연 SARS-COV-2 단백질에서 면역원성을 나타내지 않는 RBM 펩타이드를 강화하여 강력한 중화 항체 반응을 이끌어냅니다.Article Published on 2022-04-012022-09-11 Journal: Nanomedicine : nanotechnology, biology, and medici [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus affinity Antigen antigenicity Antisera candidate carrier protein core antigen coronavirus demonstrated effective delivery elicit epitope Epitopes HBcAg immunization in vitro inactivated indicate KLH linear mice motif Multi-epitope vaccine Neutralizing activity neutralizing antibody Neutralizing antibody response New overlapping Particle peptide peptide epitope peptides Protein RBM reactivity receptor binding motif receptor-binding motif Receptor-binding motif (RBM) recombinant respiratory robust S1 protein severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Vaccine variants virus virus infection virus mutation Virus-like particle virus-like particles Virus-like particles (VLPs) VLP VLPs [DOI] 10.1016/j.nano.2022.102527 PMC 바로가기 [Article Type] Article
In silico analysis of mutant epitopes in new SARS-CoV-2 lineages suggest global enhanced CD8+ T cell reactivity and also signs of immune response escape새로운 SARS-CoV-2 계통에서 돌연변이 에피토프의 실리코 분석은 전 세계적으로 향상된 CD8+ T 세포 반응성과 면역 반응 탈출의 징후를 시사합니다Article Published on 2022-04-012022-09-11 Journal: Infection, genetics and evolution : journal of mol [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료법, [키워드] Analysis antibody B.1.1.7 B.1.351 binding Binding prediction Brazil CD8+ CD8+ T cell CD8+ T cell response CD8+ T cells change class Class I HLA conserved country Coverage COVID-19 E484K epitope Epitopes evade Evidence exhibiting expected fraction highlight HLA allele HLA alleles HLA binding immune response immunogenic in silico individual investigated Lineage lineages mutant Mutation N501Y new SARS-CoV-2 P.1 P.2 peptide peptides predicted provided reactivity reference sequence respond response SARS-CoV-2 SARS-CoV-2 variants silico predictions South Africa spike T cell T cell epitopes T cells TCR Transmissibility variant variants variants of concern Viral load [DOI] 10.1016/j.meegid.2022.105236 PMC 바로가기 [Article Type] Article
Longitudinal immune profiling reveals dominant epitopes mediating long-term humoral immunity in COVID-19-convalescent individuals세로 방향 면역 프로파일링은 COVID-19 회복기 개인의 장기 체액성 면역을 매개하는 지배적인 에피토프를 나타냅니다Article Published on 2022-04-012022-09-11 Journal: The Journal of Allergy and Clinical Immunology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus Analysis antibody Antibody Response caused circulating variants concerning contagious coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients COVID-19-convalescent individual COVID-19-convalescent individuals cytokine cytokine production diagnostic disease onset dissect dominant dominant epitope early stage early stages endemic human coronavirus endemic human coronaviruses epitope Epitopes fatality feature global pandemic highly pathogenic humoral humoral immune responses Humoral immunity immune immune profiling immune response immune responses Immunity individual induce Kinetics long-term immune response long-term immune responses Longevity longitudinal longitudinal analysis mapped moderate moderate symptoms N-terminal domain Neutralizing antibodies neutralizing antibody ORF1ab path patients peptide peptide microarray performed Protein Proteins proteome proteome-wide peptide microarray. reactive respiratory responsible reveal S1 subunit S2 subunit SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 spike protein sequence homology sequence identity severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown specific antibodies Spike protein sustained symptoms of COVID-19 the early SARS-CoV-2 the S1 subunit the SARS-CoV-2 Vaccine design Wuhan-Hu-1 [DOI] 10.1016/j.jaci.2022.01.005 PMC 바로가기 [Article Type] Article
Cytotoxic T lymphocytes targeting a conserved SARS-CoV-2 spike epitope are efficient serial killers보존된 SARS-CoV-2 스파이크 에피토프를 표적으로 하는 세포독성 T 림프구는 효율적인 연쇄 살인범입니다Article Published on 2022-04-012022-09-11 Journal: BioTechniques [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] conserved convalescent patient COVID-19 cytokine cytokine secretion Cytokines cytotoxic cytotoxic T lymphocyte cytotoxic T lymphocytes cytotoxicity eliminating epitope Evidence functions humoral responses immune response Immunity implication infected individuals Infection Lymphocytes machine learning Microscopy Neutralizing antibody response neutralizing antibody responses SARS-CoV-2 SARS-CoV-2 spike single-cell specificity Spike protein surrogate T cell T cells T lymphocyte target target cells targets These data Time-lapse imaging understanding Vaccine Vaccine development variants of concern Viral viral infection while [DOI] 10.2144/btn-2022-0016 PMC 바로가기 [Article Type] Article