PKA activity is essential for relieving the suppression of hyphal growth and appressorium formation by MoSfl1 in Magnaporthe oryzaePKA 활성은 Magnaporthe oryzae에서 MoSfl1에 의한 균사 성장 및 부착기 형성 억제를 완화하는 데 필수적입니다.Research Article Published on 2017-08-142022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Activation affinity Affinity purification Author C-terminal CAMP catalytic subunit cellular processe characterized co-IP conidia conidiation conserved Critical Deletion downstream eukaryotic cell eukaryotic cells Extracellular function functional functions Fusarium growth growth defect hyphal Infection insertion Interaction invasive involved IP assays loss-of-function mutation loss-of-function mutations Magnaporthe mutant mutants Mutation overlapping Pathogenesis pathway penetration Phosphorylation PKA produced purification reduced regulate regulated repressor residue response signaling pathway significantly strain Strains suppress suppressed suppression suppressor suppressors transcription factor transcriptional Treatment was reduced yeast [DOI] 10.1371/journal.pgen.1006954 PMC 바로가기 [Article Type] Research Article
Salmonella Intracellular Lifestyles and Their Impact on Host-to-Host Transmissionarticle Published on 2017-07-312024-09-01 Journal: Microbiol Spectr [Category] 살모넬라증, [키워드] autophagy carrier state cytosolic bacteria Extracellular Intracellular lifestyle persistence Salmonella-containing vacuole Transmission [Article Type] article
Characterization of anti-MERS-CoV antibodies against various recombinant structural antigens of MERS-CoV in an imported case in ChinaOriginal Article Published on 2016-11-092022-10-31 Journal: Emerging Microbes & Infections [Category] Coronavirus, [키워드] antibody Antibody titer Antigen characterization China correlated correlation domain ELISA ELISAs enzyme-linked immunosorbent enzyme-linked immunosorbent assay Extracellular inactivated Infection MERS MERS coronavirus MERS-CoV Middle East N-terminal domain neutralization neutralizing antibody NTD occurred Patient pseudovirus RBD RBD ELISA recombinant structural antigens sera Seroconversion significantly Strong syndrome the patient [DOI] 10.1038/emi.2016.114 PMC 바로가기 [Article Type] Original Article
Cytokine systems approach demonstrates differences in innate and pro-inflammatory host responses between genetically distinct MERS-CoV isolatesResearch Article Published on 2014-12-222022-10-28 Journal: BMC Genomics [Category] Coronavirus, [키워드] Activation acute respiratory syndrome Amino acid Analysis analyzed approach Atypical Calu-3 caused Cell cell line changes changes in clinical Clustering Computational topology coronavirus Cytokine simulation differential expression epithelial Extracellular feature filtered Gene Expression highly pathogenic homology host response human airway epithelial human Calu-3 humans IFN IL-1α in viral include Infection innate immune Innate immunity isolate kinetic magnitude MERS MERS-CoV MERS-CoV infection Middle East modulate Novel coronavirus pathogenic patients performed persistence Pneumonia post infection pro-inflammatory pro-inflammatory responses progressive respiratory failure Protein respiratory virus responses Result SARS-CoV Signaling STAT3 statistical analysis strain Strains supplementary material syndrome TNF transcriptional transcriptional change transcriptional difference transcriptomics zoonotic [DOI] 10.1186/1471-2164-15-1161 PMC 바로가기 [Article Type] Research Article
Polymorphisms in the feline TNFA and CD209 genes are associated with the outcome of feline coronavirus infectionResearch Published on 2014-12-162022-10-28 Journal: Veterinary Research [Category] Coronavirus, MERS, [키워드] A allele allele Alpha association Birman caused CD209 coronavirus Coronavirus infection DC-SIGN Denmark disease domain ECD effective therapy Extracellular facilitate Feline infectious peritonitis FIVE genetic trait Genetic variant Genotype groups Host host gene immune-mediated disease Infection intron lethal disease multifactorial Necrosis Occurrence outcome populations promoter reduce significant difference Single nucleotide polymorphism SNP SNPs statistical suggested supplementary material susceptibility TNF-α USA variant [DOI] 10.1186/s13567-014-0123-6 PMC 바로가기 [Article Type] Research
Role of the Spike Glycoprotein of Human Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in Virus Entry and Syncytia FormationResearch Article Published on 2013-10-032022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] 293T cell activate Affect antibody bats Betacoronavirus blocked cathepsin L cathepsin L-dependent Cell cell type Cl cleave cleaved co-expressed coronavirus coronavirus spike glycoprotein determined elicit endosome Eptesicus experiment Express Extracellular fluids Formation function glycoprotein host cell host protease host range Human immunoblot inhibitor lentivirus maturation membrane fusion MERS MERS-CoV MERS-CoV S protein MHV Middle East murine Neutral Neutralizing antibodies New World non-infectious plasma membrane polyclonal produced producing pseudotype pseudovirion pseudovirus entry reagent receptor released Research respiratory role S protein S2 domain serine protease Spike protein Syncytia syncytia formation the S protein the Spike tissue Treatment triggered trypsin variety VERO E6 cells viral spike virus virus entry [DOI] 10.1371/journal.pone.0076469 PMC 바로가기 [Article Type] Research Article
Arabidopsis thaliana RESISTANCE TO FUSARIUM OXYSPORUM 2 Implicates Tyrosine-Sulfated Peptide Signaling in Susceptibility and Resistance to Root InfectionArabidopsis thaliana FUSARIUM OXYSPORUM 2에 대한 내성은 뿌리 감염에 대한 감수성과 내성에 티로신-황산염 신호 전달을 의미합니다Research Article Published on 2013-05-232022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] acting Affect Arabidopsis thaliana Diversity downregulate effector explain expression Extracellular Fusarium Gene Genes host immunity induce Infection inhibit lethal leucine loci locus mutant mutants negative feedback pathogen-specific peptide plant promote Protein provide QTLs Quantitative receptor Regulation related relative susceptibility replaced resistance root Signaling Support suppresse susceptibility traits transgenic tyrosine Vascular while [DOI] 10.1371/journal.pgen.1003525 PMC 바로가기 [Article Type] Research Article
A Mechanism of Gene Amplification Driven by Small DNA Fragments작은 DNA 조각에 의한 유전자 증폭 메커니즘Research Article Published on 2012-12-132022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] amplification amplified amplify annealing Author Cancer cancer cell Cancer cells capture cause Cell chromosomal chromosomal DNA chromosomal region contribute copy number degenerative dependent on detected disorders DNA DNA amplification DNA fragment driving duplication Efficiency elevated event events expression Extracellular Factor favor found fragment Frequency gene amplification Genetic variation genomic homology Human increase independent independent of initiated involved loci mechanism molecular molecular mechanism molecular mechanisms nucleotide nucleotides occur oligonucleotide Organisms Patients with cancer polymorphism Rad1 Rad51 Rad52 regions S. cerevisiae Saccharomyces cerevisiae serum single-stranded stimulate Trigger triggered Variation yeast [DOI] 10.1371/journal.pgen.1003119 PMC 바로가기 [Article Type] Research Article
The Regulatory Network of Natural Competence and Transformation of Vibrio choleraeVibrio cholerae의 자연적 능력 및 변형의 규제 네트워크Research Article Published on 2012-06-212022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] a major Analysis aquatic bacterium aquatic environment assays Author autoinducers Bacteria Bacterial bacterium CAMP carbon Carbon catabolite repression catabolite repression Cell chitin chitinous chitinous exoskeleton colonization Combination competence condition conditions consequence contribute Degradation degradation products dependent on determine developmental different DNA ecological environmental niche environmental reservoirs Evidence Evolution Express expression pattern Extracellular Factor found Gene Gene Expression gene transfer Genes Genetic genetic transformation genomes growth heterogeneity heterogeneous homogeneous horizontal gene Horizontal gene transfer human pathogen immunological detection initiate intracellular signaling investigated involved lead maintenance majority metabolism mode natural Natural competence natural transformation network organism pathogenic phenotype protein level protein levels quantitative RT–PCR quorum-sensing pathways regions regulated regulatory circuit released reporter fusions required signaling cascade signaling pathway single cell level tested TfoX the cells transcriptional transfer transformation V. cholerae Vibrio cholerae western blot Western blot analysis zooplankton [DOI] 10.1371/journal.pgen.1002778 PMC 바로가기 [Article Type] Research Article
Reduced Lentivirus Susceptibility in Sheep with TMEM154 MutationsTMEM154 돌연변이가 있는 양의 렌티바이러스 감수성 감소Research Article Published on 2012-01-262022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] 95% CI Affect affecting age allele Analysis analyzed Author biological function Case-control cause caused coding region Cohort disease domain E35 exceeded expressed Extracellular FIVE form forms frameshift full-length genetic risk factor genetic risk factors Genetic variation Genome-wide association study genome-wide significance Genotype Glutamate greater Haplotype haplotypes help homozygous host immune system identify incurable Infected infected case infected cases Infection isoform lentivirus lysine mechanism Missense multi multiple tissues mutant mutant virus Mutation nine odds of infection Older P -value peptide Pneumonia position predicted primates PROTECT Protein Reinfection Relative risk remained repeated respiratory Retroviral infection risk of infection Sanger sequencing sheep signal peptide single SNP susceptible target The United States TMEM154 transmembrane protein uninfected uninfected control United States Variation were used with infection [DOI] 10.1371/journal.pgen.1002467 PMC 바로가기 [Article Type] Research Article