genomes – Page 23 – Communicable Diseases Research

Identity-by-descent analyses for measuring population dynamics and selection in recombining pathogens

재결합 병원체에서 개체군 역학 및 선택을 측정하기 위한 혈통별 식별 분석

Research Article

Published on 2018-05-232022-09-06
Journal: PLoS Genetics [Category] Communicable Disease, 말라리아,

Genome-wide detection of conservative site-specific recombination in bacteria

박테리아에서 보존적 부위 특이적 재조합의 게놈 전체 검출

Research Article

Published on 2018-04-052022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] addition adopted Altering Analysis appear applicability applied approach archaeal Bacteria Bacterial bacterial specy characterization classical Clostridium difficile components condition conserved contributing to dataset dependent on described detect DNA ecological niche ecological niches Effectiveness Epidemic expand expressed Features fluctuations fluorescent Frequency Gene Expression generate genomes genomic Genomic DNA growth heterogeneity identify in some in vitro inversion lack lineages mechanism nucleotide occur opens pathogen pathogenic bacteria phenotypic platform Population population level Prevalence proliferation provide Rapid Recombination referred to responsible robust Sequencing single-nucleotide stationary strain subpopulation survival thought undergo Variation
[DOI] 10.1371/journal.pgen.1007332 PMC 바로가기 [Article Type] Research Article

Novel genetic polymorphisms associated with severe malaria and under selective pressure in North-eastern Tanzania

심각한 말라리아 및 탄자니아 북동부의 선택적 압력과 관련된 새로운 유전적 다형성

Research Article

Published on 2018-01-302022-09-06
Journal: PLoS Genetics [Category] Communicable Disease, 말라리아,

[키워드] acquisition African allele frequencies allele frequency analyses approach association caused Cell characterisation chromosome chromosome 4 Cohort country dataset Endemic Evidence evidence of expected extended haplotype Factors Frequency GCLC gene mutation gene target Genetic genetic factors genetic mutation genetic mutations Genetic polymorphism Genome Genome-wide association studies Genome-wide association study genomes genotyping GWAS haplotypes HbS High-resolution histocompatibility Host Human genome human population human populations identification identify immunological pathways imputation independent Intervention joint KLHL3 linkage loci Major major histocompatibility complex malaria malarial disease mechanism MHC molecular morbidity Mortality natural selection novel parasites performed Phenotypes phenotypic phenotypic variation Plasmodium falciparum Plasmodium falciparum infection polymorphism Population Positive selection Protective Protein Rare variants receptor reduced risk Region Research resulting risk factor selection pressure selective Sequencing severe malaria sickle cell sickle cell trait Significant significant effect SNPs Structural variant structural variants sub-Saharan Africa susceptibility susceptibility loci SYNJ2BP target variant Variation whole genome Whole genome sequencing
[DOI] 10.1371/journal.pgen.1007172 PMC 바로가기 [Article Type] Research Article

High rate of adaptation of mammalian proteins that interact with Plasmodium and related parasites

Plasmodium 및 관련 기생충과 상호 작용하는 포유류 단백질의 높은 적응률

Research Article

Published on 2017-09-282022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] adaptation adaptive allele ancestor Bacterial infections Blood blood cell caused cell membrane cell protein conserved controls Critical critical organ curated disease domain domains driven by elevated Evidence Evolution expected explained expression Genetic genetic resistance genomes group Host host adaptation host gene host protein host proteins hosts Human genome human populations humans identify illness immune immune function infect Infection Infectious disease Interaction involved lack life cycle liver malaria mammal mammalian mammalian protein mammals many cases matched control matched controls non-immune organ outcome over parasite parasites pathogen Pathogens Plasmodium Plasmodium falciparum Pleiotropy Protein Proteins red blood cell relative representing second selective significantly spectrin Substitution susceptibility terrestrial the strongest title variety Viral
[DOI] 10.1371/journal.pgen.1007023 PMC 바로가기 [Article Type] Research Article

Porcine Epidemic Diarrhea in Europe: In-Detail Analyses of Disease Dynamics and Molecular Epidemiology

Article

Published on 2017-07-062022-10-28
Journal: Viruses [Category] Coronavirus, MERS,

Evidence for the evolutionary steps leading to mecA -mediated β-lactam resistance in staphylococci

포도상구균에서 mecA 매개 β-락탐 내성으로 이어지는 진화 단계에 대한 증거

Research Article

Published on 2017-04-102022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] accumulation acquisition adaptation Amino acid Analysis antibiotic Antibiotic resistance Antibiotics Author Bacteria Bacterial Bayesian analysis binding binding domain cell wall cell wall synthesis changes in chromosome Community core genome development domain driving epidemiologically Evolution exposure to food additives gene encoding Genetic genetic background genomes highlight homologue identify involved isolates livestock mechanism mechanisms methicillin methicillin-resistant Staphylococcus aureus Mortality MRSA mutation rate Mutation rates non-binding nucleotide occur occurred oxacillin Pandemics PBP penicillin phenotype Phylogenetic analysis precursor predicted profiles promoter promoters Protein representing resistance gene resource responsible S . aureus SCC selective sequence sequence alignments sequenced genome single-nucleotide polymorphism SNP species Spread Staphylococcus Staphylococcus aureus strain Substitution substitutions susceptibility variety was performed
[DOI] 10.1371/journal.pgen.1006674 PMC 바로가기 [Article Type] Research Article

Genomes of Fasciola hepatica from the Americas Reveal Colonization with Neorickettsia Endobacteria Related to the Agents of Potomac Horse and Human Sennetsu Fevers

Potomac Horse 및 Human Sennetsu Fever의 대리인과 관련된 Neorickettsia Endobacteria로 아메리카 대륙에서 Fasciola hepatica의 게놈이 식민지를 나타냅니다.

Research Article

Published on 2017-01-062022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] agent America Bacteria biliary tract Biology cattle cestodes colonization Comparative genomics Complete contig disease etiological agent Evolution facilitate Fasciola hepatica Fascioliasis female reproductive tract fevers fluke food food chain Gene Expression Genome genome sequence genomes genus Health hepatica heterogeneous horizontal transmission horse Host Human humans indicated Interaction interactions involved isolate less lining liver liver fluke mammalian manuscript mechanism Migration Neorickettsia NTD NTDs offered oral sucker oral suckers organ organs parasite pathogen Pathogens pathophysiology platyhelminth potential mechanism predicted Protein reference genome reported reproductive resource ruminant ruminants schistosome seminal vesicle sequence Sequencing sheep species surface protein survival tissue tissues Transmission transmitted trematode tropical Tropical Diseases variety vertical transmission Vesicle zoonotic
[DOI] 10.1371/journal.pgen.1006537 PMC 바로가기 [Article Type] Research Article

Amplification of TLO Mediator Subunit Genes Facilitate Filamentous Growth in Candida Spp .

TLO 중재자 소단위 유전자의 증폭은 칸디다 종에서 필라멘트 성장을 촉진합니다.

Research Article

Published on 2016-10-142022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] Activation amplification amplitude ascomycete ascomycetes binding domain bloodstream infection Bloodstream infections Candida Candida albican Candida albicans candidiasis cause cell physiology complex death DNA domain Engineering ENhance environmental cues eukaryotic exhibit facilitated Filamentous fungal fungi gene family Genome genomes genomic growth hallmark individual Infection infections Interaction less mediator mortality rate multitude murine mutant Nuclear localization nuclear localization signal nucleus ortholog overexpressed overexpression pathogenicity phenotype Phenotypes phenotypic plasticity Protein provide reduced regulate subunit Support systemic Candidiasis systemic infection target targets The United States Transcription transcription factor transcription factors transcriptional transcriptional activation unique United States virulence
[DOI] 10.1371/journal.pgen.1006373 PMC 바로가기 [Article Type] Research Article

Comparative Genomics of the Sigatoka Disease Complex on Banana Suggests a Link between Parallel Evolutionary Changes in Pseudocercospora fijiensis and Pseudocercospora eumusae and Increased Virulence on the Banana Host

바나나에 대한 Sigatoka 질병 복합체의 비교 유전체학은 Pseudocercospora fijiensis와 Pseudocercospora eumusae의 병렬 진화적 변화와 바나나 숙주의 독성 증가 사이의 연관성을 시사합니다

Research Article

Published on 2016-08-112022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] acquisition adaptation Analysis analyzed assimilation banana biological process caused cell walls change changes in Comparative Comparative analysis Comparative genomics complementary complex conserved convergent evolution core gene Degradation disease disease control Diversity Dothideomycetes driven by effective effector proteins effectors Evolution evolutionary relationships facilitate facilitated fungi gene count gene families gene family Genes Genome genome architecture genome sequence genomes genomic genomic change Genomics higher efficiency Host host immune system identify increase in Increased indicated involved LTR management metabolic pathway metabolic pathways metabolism Modification pathogen pathogenic Pathogens plant cell profile proliferation Radiation remained sequenced Seven significant difference significant differences speciation Still supported understanding utilization virulence virulent
[DOI] 10.1371/journal.pgen.1005904 PMC 바로가기 [Article Type] Research Article

Genetic Drift, Purifying Selection and Vector Genotype Shape Dengue Virus Intra-host Genetic Diversity in Mosquitoes

모기의 유전적 드리프트, 정제 선택 및 벡터 유전자형 모양 뎅기열 바이러스 숙주 내 유전적 다양성

Research Article

Published on 2016-06-152022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] acting Adaptability adaptive addition alteration anatomical Arboviruses arthropod vector arthropod vectors arthropod-borne breadth Critical deep sequencing deleterious mutation Deleterious mutations Dengue dengue virus dengue viruses Diversity drift effective Evolution Factor fitness fluctuation full-length Genetic genetic background genetic diversity genetic drift genetic factors genetic heterogeneity genomes Genotype High-throughput sequencing host infection identifying Infection initial maintenance midgut infection MONITOR Mosquito natural natural selection Population population bottleneck population bottlenecks Population size populations provide purging Purifying random Randomly reduce reductions in Replication resulting RNA virus RNA viruses Selection Sequencing shape significantly the mosquito variant vector vectors Viral viral genome viral genomes virus virus genomes viruses wild-type
[DOI] 10.1371/journal.pgen.1006111 PMC 바로가기 [Article Type] Research Article