Seroprevalence and Transmission of Human Influenza A(H5N1) Virus before and after Virus Reassortment, Cambodia, 2006–2014Article Published on 2017-02-012023-05-31 Journal: Emerging Infectious Diseases [Category] Fulltext, 조류인플루엔자, [키워드] Avian influenza virus Cambodia H5N1 virus highly pathogenic humans Influenza poultry Reassortment seroepidemiologic study Seroprevalence Transmission viruses [DOI] 10.3201/eid2302.161232 PMC 바로가기
Understanding the early dynamics of the 2014 porcine epidemic diarrhea virus (PEDV) outbreak in Ontario using the incidence decay and exponential adjustment (IDEA) modelResearch Article Published on 2017-01-052022-10-28 Journal: BMC veterinary research [Category] Coronavirus, MERS, [키워드] Accuracy applied Canada Characteristics Combination Course Critical cumulative decrease Developing disease Disease dynamics disease transmission effective Epidemic epidemic diarrhea epidemiological estimate evaluated feasible Forecasting Generation time help helping highly pathogenic implementation incidence initial iterative likelihood modeling morbidity and mortality outbreak parameter parameters pathogen PEDV PIGS Porcine epidemic diarrhea virus Result Spread subset swine the epidemic Transmission understanding United State virus [DOI] 10.1186/s12917-016-0922-2 PMC 바로가기 [Article Type] Research Article
The Conserved Coronavirus Macrodomain Promotes Virulence and Suppresses the Innate Immune Response during Severe Acute Respiratory Syndrome Coronavirus InfectionResearch Article Published on 2016-12-132022-10-29 Journal: mBio [Category] Coronavirus, MERS, [키워드] abrogate acute respiratory syndrome ADP-ribose ADP-ribosylation antiviral property Cell culture changes in conserved coronavirus Coronavirus infection CoVs disease domain elicited enzyme epithelial cell line help highly pathogenic human CoV IFN Impact in viral in vitro Inclusion Infection Innate innate immune response Innate immunity interferon interferon-stimulated gene ISG lethal disease macrodomain mechanism mice Modification mutant virus Mutation mutations nonstructural protein 3 Nsp3 Pathogenesis positive-sense Proinflammatory cytokine promote PROTECT Protein protein targets Proteins reduced reducing reduction regulate Regulation Replication respiratory response RNA viruses SARS-CoV SARS-CoV infection strain suppressed target therapy understanding Viral load virulence virus virus attenuation [DOI] 10.1128/mBio.01721-16 PMC 바로가기 [Article Type] Research Article
Highly Pathogenic Eurasian H5N8 Avian Influenza Outbreaks in Two Commercial Poultry Flocks in CaliforniaCase Reports Published on 2016-09-012023-06-01 Journal: Avian diseases [Category] 조류인플루엔자, [키워드] Avian Influenza California chickens commercial highly pathogenic Turkeys [DOI] 10.1637/11314-110615-Case.1 [Article Type] Case Reports
HTCC: Broad Range Inhibitor of Coronavirus EntryResearch Article Published on 2016-06-012022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] acute infection block chloride common cold coronavirus drug effective inhibitor HCoV-229E HCoV-HKU1 HCoV-NL63 HCoV-OC43 highly pathogenic Hospitalization human coronavirus human coronaviruses humans Immunocompromised patient Infants Infection inhibit inhibitor Interaction MERS coronaviruses Polymer Range receptor respiratory infection severe disease therapy virus [DOI] 10.1371/journal.pone.0156552 PMC 바로가기 [Article Type] Research Article
Factors Associated with Highly Pathogenic Avian Influenza H5N2 Infection on Table-Egg Layer Farms in the Midwestern United States, 2015Article Published on 2016-06-012023-06-01 Journal: Avian diseases [Category] 조류인플루엔자, [키워드] Avian Influenza H5N2 highly pathogenic Risk factors table-egg layers. [DOI] 10.1637/11351-121715-Reg
Exploiting Genetic Interference for Antiviral Therapy항바이러스 치료를 위한 유전자 간섭 활용Review Published on 2016-05-052022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, 신종인플루엔자, [키워드] Antiviral strategies Cell circumvent competing de novo dominant drug resistance Ebola virus Evolution generate Genetic genetic diversity Genome genome replication Health heterogeneity heterogeneous highly pathogenic HIV Influenza Influenza virus inherent interfere Interference Particles Population power replicate therapeutic therapeutic intervention therapy Treatment Viral viral fitness viral variant virus viruses [DOI] 10.1371/journal.pgen.1005986 PMC 바로가기 [Article Type] Review
Middle East respiratory syndrome coronavirus M protein suppresses type I interferon expression through the inhibition of TBK1-dependent phosphorylation of IRF3Original Article Published on 2016-04-202022-10-31 Journal: Emerging Microbes & Infections [Category] Coronavirus, [키워드] Activation antiviral response association C-terminal C-terminal domain characterized chimeric claimed conserved contribute evade ex vivo models expression highly pathogenic Host IFN induce infected patient Infection inhibitory effect innate antiviral response interferon IRF3 IRF3 activation M protein mechanism MERS coronavirus MERS-CoV Middle East mutants N-terminal nuclear Pathogenesis Phosphorylation Protein reduced Regulatory respiratory syndrome coronavirus resulting RIG-I-like receptors SARS-CoV Saudi Arabia Sendai virus suppress suppresse suppressed TRAF3 transmembrane domain Type I IFN type I interferon type I interferons [DOI] 10.1038/emi.2016.33 PMC 바로가기 [Article Type] Original Article
Surveillance for Eurasian-origin and intercontinental reassortant highly pathogenic influenza A viruses in Alaska, spring and summer 2015Short Report Published on 2016-03-312023-05-31 Journal: Virology Journal [Category] Fulltext, [키워드] Alaska H5N1 H5N2 H5N8 highly pathogenic Influenza Migratory bird Yukon-Kuskokwim Delta [DOI] 10.1186/s12985-016-0511-9 PMC 바로가기 [Article Type] Short Report
Middle East Respiratory Syndrome Coronavirus NS4b Protein Inhibits Host RNase L ActivationResearch Article Published on 2016-03-292022-10-29 Journal: mBio [Category] Coronavirus, [키워드] accessory protein activate Activation acute respiratory syndrome antiviral activity Betacoronavirus calu-3 cells cell death characterized cleave contribute coronavirus Coronaviruses CoV Critical cytoplasmic dsRNA enzyme expressed expression level genes encoding Genome highly pathogenic homolog Host host antiviral response host innate immunity IFN IFN signaling in vivo model inactivation Infection Innate immunity interferon involved Like Lineage mechanism MERS MERS-CoV MERS-CoV infection Middle East murine mutant NLS NS2 NS4b nuclear localization signal nucleus offer other coronaviruses Pathogenesis pathway potential mechanism Prevent Protein provide Replication reported required respiratory respiratory syndrome coronavirus RNA RNase SARS-CoV single-stranded Spread ssRNA subsequent therapeutic intervention translational type I interferon viral double-stranded RNA viral pathogenesis viral replication virulence [DOI] 10.1128/mBio.00258-16 PMC 바로가기 [Article Type] Research Article