Predicting the recombination potential of severe acute respiratory syndrome coronavirus 2 and Middle East respiratory syndrome coronavirusResearch Article Published on 2020-12-092022-10-30 Journal: The Journal of General Virology [Category] COVID-19, SARS, [키워드] ACE2 acute respiratory syndrome analysed analyses anatomical cause cellular receptor co-expression Co-infection coronavirus develop diagnostic DPP4 emergence facilitate Fatality rate genomic region high-risk area homologous humans identify Infection interacting residues investigated Kingdom Laboratory MERS-CoV MERS-CoV RNA Middle East ORF1ab outbreak Patient predictions public health Recombination recombination event reported respiratory syndrome coronavirus S gene SARS-CoV-2 SARS-COV-2 infection Saudi Arabia susceptibility Virus spike widespread [DOI] 10.1099/jgv.0.001491 PMC 바로가기 [Article Type] Research Article
A 3.4-Å cryo-electron microscopy structure of the human coronavirus spike trimer computationally derived from vitrified NL63 virus particlesResearch Article Published on 2020-11-172022-10-29 Journal: Qrb Discovery [Category] COVID-19, [키워드] ACE2 activating addition antibody binding biochemically cause children coronavirus Cryo-electron microscopy cryo-EM domain drugs ectodomain explain family Coronaviridae glycosylation HCoV-NL63 homologous Human human coronavirus NL63 immunocompromised individuals Mild NL63 Particles pathogen provide purified receptor receptors respiratory diseases Respiratory illness S trimer SARS-CoV-1 SARS-CoV-2 shown Spike protein spike trimer Spread structures trimer upper respiratory symptom viral entry virion virus particle [DOI] 10.1017/qrd.2020.16 PMC 바로가기 [Article Type] Research Article
Structure-Based Modeling of SARS-CoV-2 Peptide/HLA-A02 AntigensMedical Technology Published on 2020-11-172022-11-01 Journal: Frontiers in Medical Technology [Category] COVID-19, [키워드] 3D model approach Asymptomatic can be used CD4 CD8 CD8 T cell common allele common cold coronavirus complex complexes COVID-19 cross-reactive database diagnostic disease electrostatic epitope epitope cross-reactivity Epitope-based vaccine Epitopes expressed HLA-A homologous identify individual MHC-I Mild modeling peptide predict predicted Protein Data Bank residue Rosetta SARS-CoV-2 SARS-COV-2 infection shown strain Structure T cell T cell epitope T cell epitopes TCRs therapeutic [DOI] 10.3389/fmedt.2020.553478 PMC 바로가기 [Article Type] Medical Technology
Unique fibrinogen-binding motifs in the nucleocapsid phosphoprotein of SARS CoV-2: Potential implications in host-pathogen interactionsSARS CoV-2의 뉴클레오캡시드 인단백질의 독특한 피브리노겐 결합 모티프: 숙주-병원체 상호작용의 잠재적 의미Article Published on 2020-11-012022-09-11 Journal: Medical Hypotheses [Category] SARS, 치료법, [키워드] Asymptomatic binding Blood blood clot Blood clots blood clotting cascade clinical manifestation clinical manifestations clinical observation Coagulase Coagulation condition contagious Corona virus coronavirus COVID-19 Critical Critical illness death disease Disseminated intravascular coagulation Economy etiological agent evade fibrinogen function functions global health Health help homologous Host Host immune response host-pathogen interaction Hypothesis immune evasion implication in vitro incidence increase in increased risk induce infected patient infected patients infecting Infection information Interaction intravascular coagulation mechanism Mild molecular mechanisms morbidity and mortality motif Motif. N-protein novel Novel coronavirus nucleocapsid pandemic Potential Protein Proteins prothrombin regulate SARS CoV SARS CoV-2 SARS CoV-2 infection Stage Staphylococcus aureus tested therapeutic strategy turn unique virus von Willebrand factor [DOI] 10.1016/j.mehy.2020.110030 PMC 바로가기 [Article Type] Article
Osmotic Adaptation by Na + -Dependent Transporters and ACE2: Correlation with Hemostatic Crisis in COVID-19Review Published on 2020-10-302022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] ACE2 acquisition adaptation Ageusia amino acids Ang II angiotensin angiotensin-converting enzyme 2 Cell cells Coagulation combinatorial treatment complex Concentration COVID-19 COVID-19 pathogenesis COVID-19 patients COVID-19 symptoms crisis D-dimer Effect elevated endothelial epithelial function furin cleavage site Glucose Hemostatic homologous Host Hyperactivation hypertension hypokalemia inactivation Inflammation mechanism necrotic death neurological Neutral non-infected Organ failure osmotic Prevent provide respiratory rupture SARS-CoV SARS-CoV-2 sequence severe complication Signaling Support thrombosis tissues tonicity transporter transporters virus [DOI] 10.3390/biomedicines8110460 PMC 바로가기 [Article Type] Review
Pervasive RNA Secondary Structure in the Genomes of SARS-CoV-2 and Other CoronavirusesResearch Article Published on 2020-10-302022-10-29 Journal: mBio [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome analyzed arise association Cell cellular interaction coding sequences complex interplay conserved contribute coronavirus coronavirus disease coronavirus genome COVID-19 dependent on element Evidence Evolution examined Features Genome greater HCV hepatitis C virus homologous Host Human identity immune dysfunction include infecting influence investigated less mammals Molecular epidemiology Mutation Other other coronavirus outcome pandemic pathogenicity persistence population immunity positioned possession predicted Prevent Prolonged infection protective immunity related viruses RNA RNA secondary structure RNA virus RNA viruses SARS-CoV SARS-CoV-2 secondary sequence shielding Site Structure Transmissibility Transmission Viral RNA virus [DOI] 10.1128/mBio.01661-20 PMC 바로가기 [Article Type] Research Article
Molecular-based cross-species evaluation of bovine coronavirus infection in cattle, sheep and goats in GhanaResearch Article Published on 2020-10-272022-10-28 Journal: BMC veterinary research [Category] Coronavirus, MERS, [키워드] Bayesian Bovine coronavirus cattle clade Clinical sign collected Cross-species infection diarrhea distress ENhance full length GenBank goat high temperature highlight homologous Host Infection isolate manifested nucleotide sequence occurred polymerase chain positive Prevalence RdRP RdRp gene rectal swab Result RNA-dependent RNA polymerase ruminant Sanger sequencing sequence sheep Surveillance switching transcriptase Variation virus [DOI] 10.1186/s12917-020-02606-x PMC 바로가기 [Article Type] Research Article
Underlying Mechanisms and Candidate Drugs for COVID-19 Based on the Connectivity Map DatabaseGenetics Published on 2020-10-272022-10-31 Journal: Frontiers in Genetics [Category] COVID-19, [키워드] ACE2 ACE2 expression acute respiratory syndrome Analysis analyzed angiotensin-converting enzyme 2 antiviral drug BALF BALF cell Bronchoalveolar lavage fluid candidate candidate drug Cell cells clinical trial co-expressed connectivity coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 database DEGs differentially expressed gene down-regulated gene drug effective expression functional enrichment functions gene cluster Genes healthy homologous identify immune defense immune dysfunction immune response indicated lung Map mechanism mRNA translation patients patients with COVID-19 performed positively correlated potential drugs public health crisis receptor reduce reflected regulatory agency Result RNA SARS-CoV SARS-CoV infection SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 synaptic transcriptome profile Transmission treat Treatment underlying mechanisms up-regulated Vaccine viral proliferation [DOI] 10.3389/fgene.2020.558557 PMC 바로가기 [Article Type] Genetics
The Structure of the Membrane Protein of SARS-CoV-2 Resembles the Sugar Transporter SemiSWEETResearch Article Published on 2020-10-192022-10-28 Journal: Pathogens and Immunity [Category] COVID-19, [키워드] acute respiratory syndrome Amino acid Analysis autophagy Biological cause coronavirus COVID-19 Critical diabete domain endocytosis envelope protein experiment form function glycoprotein glycosylated glycosylation Health help homologous homology immune evasion in silico include induce influence interact involved lysosomal M protein maintain maturation membrane membrane glycoprotein membranes MERS-CoV N protein nucleocapsid protein pandemic pathway proliferation Protein receptor Replication responsible risk RNA viruses S protein SARS-CoV SARS-CoV-2 SemiSWEET similarity structural protein Structure sucrose sugar Sugar transporter the disease the S protein the SARS-CoV-2 virus the spike protein Transport transporter Vesicle virus wild animals [DOI] 10.20411/pai.v5i1.377 PMC 바로가기 [Article Type] Research Article
The impact of the COVID-19 pandemic on pediatric operations: a retrospective study of Chinese childrenLetter to the Editor Published on 2020-10-162022-10-29 Journal: Italian Journal of Pediatrics [Category] COVID-19, MERS, SARS, [키워드] affected children China Chinese Chongqing clinician clinics comparable confirmed case coronavirus disease COVID-19 COVID-19 pandemic COVID-19 transmission healthcare facility help homologous hospital IMPROVE increased the risk individuals with COVID-19 intraoperative measure nucleic acid test operation orchidopexy outbreak pandemic Patient pediatric performed Personal protective equipment postoperative protocol remained Result Retrospective study RNA seeking significantly surgical Treatment understanding university was performed [DOI] 10.1186/s13052-020-00915-3 PMC 바로가기 [Article Type] Letter to the Editor