human cell – Page 23 – Communicable Diseases Research

Directional and reoccurring sequence change in zoonotic RNA virus genomes visualized by time-series word count

Article

Published on 2016-11-032022-10-29
Journal: Scientific Reports
[Category] Coronavirus, Fulltext, 조류인플루엔자,

Discovery of Genetic Variation on Chromosome 5q22 Associated with Mortality in Heart Failure

심부전의 사망률과 관련된 염색체 5q22의 유전적 변이 발견

Research Article

Published on 2016-05-052022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] acting activate addition African allergic allergy applied approach assays association Asthma Blood Cell chemokine chemokines chromosome clinical trial clinical trials cytokine death dendritic cell dendritic cells determinant development DNA methylation ENhance enhancer region epigenomic Evidence evidence of expressing expression Factor failure Follow-up gene encode Genetic Genetic variant Genome-wide association studies Genome-wide association study genotyping heart heart failure HEK293 high mortality human cell human tissues identify increase increased risk independent induce inhibiting knockdown leads maintain Mast cells maturation Meta-analysis molecular Monocytes Mortality multiple tissues NHLH1 Patient performed polymorphism Population populations Positive selection predicted promote replicated reporter reporter gene responses risk allele subject T helper T-cell therapeutic Therapeutics Therapies transcription factor TSLP turn variant Whole blood
[DOI] 10.1371/journal.pgen.1006034 PMC 바로가기 [Article Type] Research Article

Mice Lacking Endoglin in Macrophages Show an Impaired Immune Response

대식세포에서 엔도글린이 결핍된 마우스는 손상된 면역 반응을 보여줍니다

Research Article

Published on 2016-03-242022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] absence ACVRL1 analyzed animals Antigen autosomal dominant autosomal dominant disorder auxiliary Bacteria balance blood monocyte blood monocytes C57BL/6 cell line characterized conditions contribute deficiency described develop differentiation disorder dominant dysplasia Endoglin endotoxin ENG explain expressed expression foci function help hemorrhage hemorrhages Hereditary Hereditary hemorrhagic telangiectasia homeostasis human cell human macrophages immune immune response Impaired in vitro in vivo increased survival Infection infection rate Infectious disease Infectious diseases Inflammation internal organs knock-out Laboratory leukemic leukemic cell Lineage Macrophage macrophages malformation mice monocyte monocyte-macrophage Monocytes Mortality mouse macrophages multisystemic patients Peripheral blood peripheral blood monocytes peritoneal macrophage peritoneal macrophages peritonitis Phagocytic activity predisposition Prevalence rare disease receptor recruited Rendu-Osler-Weber syndrome response responsible show Signaling surface antigen syndrome target gene Target genes TGF-β TGF-β1 transmembrane protein triggered type I up-regulation Vascular vessel wall was reduced Weber syndrome wild-type
[DOI] 10.1371/journal.pgen.1005935 PMC 바로가기 [Article Type] Research Article

A Shared Role for RBF1 and dCAP-D3 in the Regulation of Transcription with Consequences for Innate Immunity

타고난 면역에 대한 결과와 함께 전사 조절에서 RBF1 및 dCAP-D3의 공유 역할

Research Article

Published on 2012-04-052022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] absence activate Activation affected Alter AMP AMPs antimicrobial peptide Author Bacteria Bacterial infection Bacterial pathogens Cell cell cycle cell cycle arrest cell cycle gene cell cycle genes chromatin chromatin condensation classic Cluster condensation Condensin consequence conserved decrease DNA Drosophila Drosophila melanogaster expression fat function Gene gene cluster gene clusters Genes homolog homologs human cell human cells identify immune response immune system in vivo induce Infection Innate innate immune genes Innate immunity Interaction mitosis mitotic Pathogens peptide pRB previous study promote Protein Proteins RBF1 Region regulate regulated Regulation repress retinoblastoma retinoblastoma protein role shown subset subunit suggested transcript Transcription Tumor tumor suppressor undergo unique
[DOI] 10.1371/journal.pgen.1002618 PMC 바로가기 [Article Type] Research Article

SARS coronavirus protein 7a interacts with human Ap 4 A-hydrolase

Research

Published on 2010-02-092022-10-28
Journal: Virology Journal
[Category] Coronavirus,

Human Monoclonal Antibody Combination against SARS Coronavirus: Synergy and Coverage of Escape Mutants

Research Article

Published on 2006-07-042022-10-29
Journal: PLoS Medicine
[Category] Coronavirus,

[키워드] 2003 acute respiratory syndrome Administered affected against SARS-CoV Alter Amino acid anti-SARS-CoV antibody antibody antibody concentration Antigen antigens approach arising Bacteria binding blocked Blood breadth carried caused center China close contact close person-to-person contact Combination complementary Concentration Control convalescent SARS patient coronavirus Coverage CR3014 CR3022 died different disease disease severity dose Effect effective Epidemic Epidemics epitope escape experiment feasible ferret ferrets finding generate glycoprotein Guangdong Health healthy Hong Kong Human human cell human cells human macrophage Human monoclonal antibody humans immune Immune escape immunization immunize in vitro individual effects Infected infecting Infection infectious Infectious disease information interact Interaction International killing Laboratory less limit lung damage Lung pathology mAb mAbs measure monoclonal monoclonal antibody Mutation neutralization neutralized NO organism Patient pharyngeal Prevent prevented prevention producing Prophylaxis provided quarantine recognize recognizing reduce reduction repeated replicated required Research researcher residue responsible SARS epidemic SARS-CoV SARS-CoV infection screened shown sick Spread strain suppress synergistic synergistic fashion synergy tested the disease the receptor-binding domain Travel treat variant variants viral escape viral spread virus virus Virus neutralization virus strain virus-neutralizing viruses website Wikipedia World Health Organization
[DOI] 10.1371/journal.pmed.0030237 PMC 바로가기 [Article Type] Research Article