Co-infection of SARS-CoV-2 and influenza virus causes more severe and prolonged pneumonia in hamstersSARS-CoV-2와 인플루엔자 바이러스의 동시 감염은 햄스터에서 더 심각하고 장기적인 폐렴을 유발합니다Article Published on 2021-10-282022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus adjacent area body weight Body weight loss cause caused Cell cell tropism Co-infection coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 symptoms fatality growth hamster hamsters Health IAV IL-6 immunohistochemical analyses in vivo Infection Infectious diseases Influenza influenza A influenza A virus Influenza virus inhibit Interference involved lung Lungs organ organs pathogen Pathogens Pneumonia Post-infection public health respiratory risk SARS-CoV-2 SARS-CoV-2-infected hamsters sera severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severity severity of COVID-19 significant increase Spread Symptom Virology virus viruses weight loss [DOI] 10.1038/s41598-021-00809-2 PMC 바로가기 [Article Type] Article
Dysregulated Inflammation During Obesity: Driving Disease Severity in Influenza Virus and SARS-CoV-2 Infections비만 중 조절되지 않는 염증: 인플루엔자 바이러스 및 SARS-CoV-2 감염의 질병 중증도 유발Review Published on 2021-10-282022-09-12 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, [키워드] chronic chronic inflammation Critical cytokine death disease severity dysregulated hallmark Health host defense response IAV immune response Immunity immunopathology independent risk factor Infection infections Inflammation Inflammatory response influenza A virus Influenza virus initiated Intervention low-grade inflammation Mortality obese patients obesity pandemic Prevent reduce respiratory risk SARS-CoV-2 SARS-COV-2 infection therapeutic option tissue damage trained immunity viral infection viral pathology viral respiratory infection [DOI] 10.3389/fimmu.2021.770066 PMC 바로가기 [Article Type] Review
Tetraspanins: Host Factors in Viral InfectionsReview Published on 2021-10-272022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] approach CD151 CD63 CD81 CD9 cell membrane coronavirus COVID-19 Diseases Effect Factor Health HIV Host HPV Human immunodeficiency virus human papillomavirus IAV implicated Infection Influenza influenza A virus initial mechanism Pathogenesis shown Stage syncytium formation tetraspanin transmembrane glycoprotein Treatment viral particle virus virus infection viruses Zika [DOI] 10.3390/ijms222111609 PMC 바로가기 [Article Type] Review
Influenza A Virus (H1N1) Infection Induces Microglial Activation and Temporal Dysbalance in Glutamatergic Synaptic TransmissionResearch Article Published on 2021-10-262023-06-08 Journal: mBio [Category] Fulltext, 신종인플루엔자, [키워드] flow synaptometry glutamatergic synapse transmission Influenza influenza A virus interorgan communication microglia microglial activation neuronal synapses synaptosomes [DOI] 10.1128/mBio.01776-21 PMC 바로가기 [Article Type] Research Article
Rapid Detection of SARS-CoV-2 Using Duplex Reverse Transcription-Multienzyme Isothermal Rapid Amplification in a Point-of-Care Testing현장 진료 테스트에서 이중 역전사-다효소 등온 급속 증폭을 사용한 SARS-CoV-2의 신속한 검출Cellular and Infection Microbiology Published on 2021-10-222022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 유전자 메커니즘, 치료기술, 치료제, [키워드] 229E 95% CI 95% confidence interval a low volume acute respiratory syndrome Adenovirus Amplicon amplicons amplification amplify buffer caused Concentration coronavirus coronavirus 229E cross-reaction detection diagnostics duplex multienzyme isothermal rapid amplification Efficacy extraction guanidinium human parainfluenza virus Influenza influenza A influenza A virus influenza B influenza B virus isothermal amplification lateral flow lateral flow dipstick limit of detection MERS MERS-CoV N gene National Negative predictive value nucleic acid nucleic acid test nucleic acid tests ORF1 ORF1ab ORF1ab gene Pathogens point-of-care testing Positive predictive value Precision Predictive value primer Primers probe probes qPCR Rapid reaction respiratory Respiratory pathogens respiratory syncytial virus RNA extraction SARS-CoV SARS-CoV-2 Severe acute respiratory syndrome specimen Spread suspected patient suspected patients Swab target temperature Testing virus Volume were used without RNA extraction [DOI] 10.3389/fcimb.2021.678703 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
Optimization and SAR research at the piperazine and phenyl rings of JNJ4796 as new anti-influenza A virus agents, part 1Article Published on 2021-10-152023-06-23 Journal: European journal of medicinal chemistry [Category] 신종인플루엔자, [키워드] Hemagglutinin inhibitors influenza A virus JNJ4796 Structure-activity relationship [DOI] 10.1016/j.ejmech.2021.113591
Orchestrating an Optimized Next-Generation Sequencing-Based Cloud Workflow for Robust Viral Identification during PandemicsArticle Published on 2021-10-112022-10-28 Journal: Biology [Category] COVID-19, [키워드] Accuracy acute respiratory syndrome Algorithm caused cloud cloud computing cloud workflow Complete coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 dataset evaluate events example flu H1N1 H1N1 subtype Healthcare professional Hopefully identification implementation Infectious disease influenza A virus Next-generation sequencing number of sample occurred outperform pandemic Pandemics platform powerful tool Result robust SARS-CoV-2 short-read sequencing simple swine flu was used while [DOI] 10.3390/biology10101023 PMC 바로가기 [Article Type] Article
A proof of concept study for the differentiation of SARS-CoV-2, hCoV-NL63, and IAV-H1N1 in vitro cultures using ion mobility spectrometry이온 이동성 분광법을 이용한 SARS-COV-2, HCOV-NL63 및 IAV-H1N1의 IAV-H1N1의 분화에 대한 개념 증명 연구Article Published on 2021-10-112022-09-01 Journal: Scientific Reports [Category] MERS, SARS, 신종인플루엔자, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis Analytical chemistry Antigen Biomarkers breath calculation Clinical studies collected Compound coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Culture days post infection Decision tree diagnostic test diagnostic tests faster gas analysis gold gold standard H1N1 human coronavirus IMS in vitro Influenza influenza A influenza A virus intensities intensity investigated Laboratory Novel coronavirus novel coronavirus disease organic compound organic compounds other respiratory virus Other respiratory viruses pandemic performed point-of-care Predictive markers Rapid reduced Research respiratory respiratory viruses RT-PCR test RT-PCR tests SARS-CoV-2 sensitivity Sensitivity and specificity severe acute respiratory syndrome Coronavirus Spread viral infection viruses was performed while [DOI] 10.1038/s41598-021-99742-7 PMC 바로가기 [Article Type] Article
RNA-Seq Analysis of Influenza A Virus-Induced Transcriptional Changes in Mice Lung and Its Possible Implications for the Virus Pathogenicity in MiceArticle Published on 2021-10-082023-06-07 Journal: Viruses [Category] 신종인플루엔자, [키워드] cell cycle regulation immune regulation influenza A virus macrophages Prognosis [DOI] 10.3390/v13102031 PMC 바로가기 [Article Type] Article
Increased lethality in influenza and SARS-CoV-2 coinfection is prevented by influenza immunity but not SARS-CoV-2 immunity인플루엔자 및 SARS-CoV-2 동시 감염의 치사율 증가는 인플루엔자 면역에 의해 예방되지만 SARS-CoV-2 면역은 예방되지 않습니다.Article Published on 2021-10-052022-09-12 Journal: Nature Communications [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus antibodies Coinfection Comorbidity Complete coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic elevated ENhance IAV Immunity increase Increased Infection Influenza influenza A influenza A virus influenza vaccination influenza viral Influenza virus K18-hACE2 mice lower mortality mice morbidity Mortality mouse model organs outcome pandemic Prevent prevented Probability PROTECT reducing risk SARS-CoV-2 SARS-CoV-2 immunity SARS-COV-2 infection Seasonal influenza severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe disease Spread Support susceptibility the disease These data vaccination Viral host response viral loads virus [DOI] 10.1038/s41467-021-26113-1 PMC 바로가기 [Article Type] Article