Targeting Polyamines Inhibits Coronavirus Infection by Reducing Cellular Attachment and Entry표적 폴리아민은 세포 부착 및 진입을 감소시켜 코로나바이러스 감염을 억제합니다Article Published on 2021-06-112022-09-11 Journal: ACS Infectious Diseases [Category] SARS, 유전자 메커니즘, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Antiviral antivirals attachment bat bats binding biosynthetic biosynthetic pathway cells China coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus replication Coronaviruses COVID19 Critical Depletion disease drug target Endemic Epidemic evaluate facilitate human cells human populations humans in vitro infect Infection limitation MERS MERS-CoV metabolite Middle East Middle East respiratory syndrome Coronavirus outbreak Outbreaks pathway polyamine polyamines reduce reduced replication mechanism respiratory syndrome coronavirus resulting SARS-CoV SARS-CoV-2 severe acute respiratory syndrome Coronavirus significantly Spread targeting treat widespread [DOI] 10.1021/acsinfecdis.0c00491 PMC 바로가기 [Article Type] Article
Genomic and Phenotypic Analysis of COVID-19-Associated Pulmonary Aspergillosis Isolates of Aspergillus fumigatusAspergillus fumigatus의 COVID-19 관련 폐 아스페르길루스증 분리물의 게놈 및 표현형 분석Research Article Published on 2021-06-092022-09-10 Journal: Microbiology Spectrum [Category] MERS, SARS, 변종, 유전자 메커니즘, [키워드] A. fumigatus acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed aspergillosis Aspergillus Aspergillus fumigatus caused Cell cell wall Characteristics characterized Coinfection conducted copy number copy number variant Copy number variants coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient deleted described drugs etiological agent example expand Factors fungal disease fungal pathogen fungal pathogens genetic determinant Genome Genome sequencing genomes genomic genus Germany global pandemic growth had more information isolate isolates loss-of-function mutation metabolite microbial modulate mutational spectrum North nucleotide osmotic outcome oxidative pathogenicity Pathogens patients treated Phenotypes phenotypic Polymorphisms profile pulmonary pulmonary aspergillosis reference strain reference strains reported respiratory responsible SARS-CoV-2 Secondary infection secondary infections Secondary Metabolite severe acute respiratory syndrome Coronavirus significant difference significant differences significantly more single nucleotide polymorphisms strain Strains stressors subset superinfection virulence virulence factors virulent Wuhan Wuhan, China [DOI] 10.1128/Spectrum.00010-21 PMC 바로가기 [Article Type] Research Article
Scaffold Hopping of α-Rubromycin Enables Direct Access to FDA-Approved Cromoglicic Acid as a SARS-CoV-2 M Pro InhibitorArticle Published on 2021-06-052022-10-28 Journal: Pharmaceuticals [Category] COVID-19, [키워드] α-rubromycin Streptomyces collinus access acid antibiotic binding free energy catalytic activity Cheminformatics COVID-19 COVID-19 pandemic Critical cromolyn cytotoxicity Direct docking Drug discovery effective enzyme feature fibroblast globe help highlight Hopping in silico in vitro inhibit introduced MPro medication metabolite microbial MNP Molecular dynamics simulation offer Pro reduce SARS-CoV-2 Streptomyce suppress therapeutic efficacy time-consuming Toxicity Vaccines Virtual screening was used [DOI] 10.3390/ph14060541 PMC 바로가기 [Article Type] Article
FDA-approved thiol-reacting drugs that potentially bind into the SARS-CoV-2 main protease, essential for viral replication바이러스 복제에 필수적인 SARS-CoV-2 주요 프로테아제에 잠재적으로 결합하는 FDA 승인 티올 반응 약물Article Published on 2021-06-012022-08-31 Journal: Journal of biomolecular structure & dynamics [Category] MERS, SARS, 치료제, [키워드] 3CL 3CL main protease 3CL pro absence ACE-2 acute respiratory syndrome alcoholism angiotensin Angiotensin-converting enzyme antimicrobial antiviral drug antiviral drugs Antiviral treatment binding Captopril cellular receptor Compound COVID-19 Cys145 disulfiram dose drug drugs Enzymes expression FDA-approved drug FDA-approved drugs high mortality host cell in silico Approach inactivation induce Infection inhibit Interaction Ligand mechanism MERS metabolite metabolites outbreak pandemic processing protease Proteins reaction replicase polyprotein replicase polyproteins required respiratory responsible Safe SARS-CoV-2 SARS-COV-2 infection Severe acute respiratory syndrome shown Side effects susceptible symptomatic tested the patient the SARS-CoV-2 therapy thiol thiol-reacting drugs. thought translated Vaccine Viral viral replication [DOI] 10.1080/07391102.2020.1764393 PMC 바로가기 [Article Type] Article
High levels of eicosanoids and docosanoids in the lungs of intubated COVID-19 patientsClinical Trial Published on 2021-06-012022-10-05 Journal: FASEB journal : official publication of the Federa [Category] SARS, 임상, [키워드] acute respiratory distress acute respiratory syndrome Analysis Anti-inflammatory arachidonate Aspirin BAL Bronchoalveolar lavage characterized Clinical outcome clinically coronavirus coronavirus disease COVID-19 COVID-19 patient deleterious effect develop docosanoids drug Effect eicosanoid Eicosanoids eoxins Fatty acid healthy control Inflammatory intubated COVID-19 patient leukotriene Lipid lipid mediator lipids LTB lung Lung inflammation mechanical ventilation metabolite modulating Patient Pneumonia pro-inflammatory responsible severe COVID-19 severe COVID-19 patient significantly specialized pro-resolving mediators subset syndrome Tandem mass spectrometry thromboxane to define Treatment was done while [DOI] 10.1096/fj.202100540R PMC 바로가기 [Article Type] Clinical Trial
A preliminary metabolites identification of a novel compound with β-adrenolytic activityArticle Published on 2021-05-292022-10-28 Journal: Pharmacological Reports [Category] COVID-19, [키워드] Abstract Aminopropan-2-ol compound Analysis API cytochrome P450 derivative Electrochemistry Faeces High-resolution identification in vitro in vivo intestine kidneys liver lung m/z mass spectrometry metabolised metabolism metabolite metabolites Orbitrap oxidative Phase I predicted renal renal clearance Result serum Structure Urine was done [DOI] 10.1007/s43440-021-00273-9 PMC 바로가기 [Article Type] Article
SARS-CoV-2 can recruit a heme metabolite to evade antibody immunitySARS-CoV-2는 항체 면역을 피하기 위해 헴 대사 산물을 모집할 수 있습니다Research Article Published on 2021-05-282022-09-12 Journal: Science Advances [Category] SARS, 진단, [키워드] access Antibody binding antibody immunity Bilirubin Biliverdin bind binding cleft concentrations conformational change Coronaviral distal dominant dominant epitope epitope evade flexible heme heme metabolism immune inhibited Interaction linear mapped mechanism metabolism metabolite Microscopy modulated N-terminal domain nanomolar affinity Neutralizing antibodies NTD physiological reactivity recruit recruitment regulated Relocation SARS-CoV-2 SARS-CoV-2 spike sera significantly subset target tetrapyrrole Viral antigen X-ray crystallography [DOI] 10.1126/sciadv.abg7607 PMC 바로가기 [Article Type] Research Article
Traditional Herbal Medicines, Bioactive Metabolites, and Plant Products Against COVID-19: Update on Clinical Trials and Mechanism of ActionsPharmacology Published on 2021-05-282022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] Action affecting Against Anti-COVID-19 Anti-infective anticancer therapies Antiviral antiviral properties approach approved Ayurved medicine bioactive metabolites clinical clinical trial conducted coronavirus COVID-19 develop drugs effective Efficacy eliminated global public health Herbal Hospitalization identify infective medications Medicine Medicines metabolite morbidity and mortality notable nutraceuticals pandemic phytochemicals Phytomedicine plant product reached researcher SARS-CoV-2 shown therapy Traditional Traditional Chinese medicine traditional Chinese medicines Vaccine Vaccines viral infection World Health Organization worldwide pandemic [DOI] 10.3389/fphar.2021.671498 PMC 바로가기 [Article Type] Pharmacology
In vitro activity of itraconazole against SARS‐CoV‐2Research Article Published on 2021-05-252022-10-04 Journal: Journal of medical virology [Category] SARS, 신약개발, 치료제, [키워드] 17‐OH itraconazole acute respiratory syndrome Animal coronaviruses Antiviral antiviral activity assays Belgian patient Caco‐2 cells carried Cell cells clinical benefit clinical study coronavirus coronavirus disease COVID‐19 demonstrated Efficacy effort EudraCT hospitalized COVID‐19 patient hospitalized COVID‐19 patients identify in vitro inhibited isolate itraconazole metabolite parent nucleoside Patient phenotypic positive control Prevent reduction reduction in Remdesivir reported SARS‐CoV‐2 SARS‐CoV‐2 shown vaccination Validity VeroE6‐eGFP cells viral replication [DOI] 10.1002/jmv.26917 PMC 바로가기 [Article Type] Research Article
Characteristics of mental health implications and plasma metabolomics in patients recently recovered from COVID-19Article Published on 2021-05-212022-10-04 Journal: Translational Psychiatry [Category] SARS, 바이오마커, [키워드] alteration alterations amino acids Analysis approach association brain regions Characteristics collected correlation Correlation analysis COVID-19 COVID-19 patient Data analysis demographic demonstrated Diagnostic markers Efficiency explain healthy control hospital discharge Human behaviour implication less lipids Local mental health metabolism metabolite metabolomics Molecular neuroscience occipital Pathways Patient performed plasma plasma metabolomics Potential biomarker purine recovered recovered COVID-19 patient Recovered COVID-19 patients recovered patient Region shortest path significantly significantly lower target two groups was performed were used widespread [DOI] 10.1038/s41398-021-01426-3 PMC 바로가기 [Article Type] Article