Endothelial Immunity Trained by Coronavirus Infections, DAMP Stimulations and Regulated by Anti-Oxidant NRF2 May Contribute to Inflammations, Myelopoiesis, COVID-19 Cytokine Storms and ThromboembolismImmunology Published on 2021-06-252022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] 48 hour ACE2 ANPEP Apoptosis Autoimmune disease cancers cardiovascular comorbidity cardiovascular disease CEACAM1 cell death changes in complexes contribute controls coronavirus Coronavirus infection Coronaviruses COVID-19 CSF1 CSF3 CVD Cytokine storms DAMP DAMPs dataset death DPP4 Endothelial cell enzyme Epigenetic ER stress examined Express expressed expression facilitate Factor Ferroptosis hours post-infection Human hyperlipidemia IL6 Immunity Inflammation innate immune innate immune responses LPS majority marker MERS-CoV Microarray mitochondrial mitotic modulated monocyte Myelopoiesis Nrf2 nucleic acid oxidative phosphorylation PAMP Proinflammatory cytokine Proinflammatory response protein complex pyroptosis receptor regulate ROS stimulated Stimulation storm Stress subsequent Thromboembolism thrombosis TMPRSS2 TNFα trained immunity transcriptomic upregulated upregulation Viremia virus entry [DOI] 10.3389/fimmu.2021.653110 PMC 바로가기 [Article Type] Immunology
Severe COVID-19 Recovery Is Associated with Timely Acquisition of a Myeloid Cell Immune-Regulatory Phenotype심각한 COVID-19 회복은 골수 세포 면역 조절 표현형의 적시 획득과 관련이 있습니다Immunology Published on 2021-06-232022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 치료기술, [키워드] Aberrant inflammatory responses acquisition Activation Admission age and sex alteration Analysis basophil basophils best CD14 CD163 CD80 CD86 Cell circulating contribute COVID-19 COVID-19 outbreak cytokine Cytokine storm demonstrated dendritic cell described detectable discharge evaluated expansion expression flow cytometry HCs healthy control healthy controls healthy subjects ICU ICU Patients IFN-γ IL-10 IL-12p40 IL1RA immune-regulation increased expression Inflammatory responses innate immune system Innate immunity intensive care intensive care unit admission M2-like differentiation management marker mDCs mediators monocyte Monocytes myeloid myeloid cell pandemic pathogenic mechanism Patient patients patients with COVID-19 PD-L1 pDCs phenotype plasma positively correlated Prognosis reduced reduction Regulatory respiratory insufficiency SARS-CoV-2 SARS-COV-2 infection serum severe COVID-19 severe disease significantly significantly higher Slan specific antibodies stratified subset Support therapeutic agent therapeutic agents therapeutic interventions Treatment Viral Viral load [DOI] 10.3389/fimmu.2021.691725 PMC 바로가기 [Article Type] Immunology
Severe Clinical Worsening in COVID-19 and Potential Mechanisms of Immune-Enhanced DiseaseMedicine Published on 2021-06-222022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] Activation acute respiratory distress aggravate alleviate alveolar antibodies antibody Asymptomatic autoantibody candidate candidate vaccine Cell clinical Clinical deterioration contribute COVID-19 COVID-19 patient Critical Critical disease cross-reactivity direct infection disease disease severity driving dysregulated immune response Effects epithelia evaluate fatal COVID-19 help host proteins Hyperinflammatory immune cells immune response Infection inflammatory monocyte inquiry Laboratory macrophages majority mechanism Mild monocyte monocytes/macrophages NETs Neutrophil extracellular trap outcomes pathology Patient platelet apoptosis Potential producing receptor SARS-CoV-2 SARS-CoV-2 coronavirus severe COVID-19 severe disease progression severity subset Support therapeutic thrombosis Vaccines viral entry viral tropism while worsening [DOI] 10.3389/fmed.2021.637642 PMC 바로가기 [Article Type] Medicine
Ketogenic diet restrains aging-induced exacerbation of coronavirus infection in miceResearch Article Published on 2021-06-212022-10-31 Journal: eLife [Category] COVID-19, MERS, SARS, [키워드] adipose Adults age aging beta coronavirus coronavirus Coronavirus infection COVID-19 infection decrease Defense expand gamma delta T cell Glycolysis hallmark immune Impact increased mortality Increasing Infection Inflammasome Inflammatory influenza infection inoculated intranasally ketogenic Ketogenic diet lung Lungs MHV MHV-A59 mice monocyte Mortality mouse mouse hepatitis virus murine NLRP3 inflammasome pathogenic Potential treatment PROTECT Protective risk of COVID-19 severity Surveillance systemic inflammation T cell T cells tissue [DOI] 10.7554/eLife.66522 PMC 바로가기 [Article Type] Research Article
The Role of Th17 Response in COVID-19Review Published on 2021-06-192022-10-31 Journal: Cells [Category] COVID-19, MERS, SARS, [키워드] activating acute infectious disease cascade caused colony stimulating factor coronavirus 2 counterproductive Course COVID-19 COVID-19 pneumonia cytokine Cytokines Defense droplet Evidence G-CSF granulocyte hospitalised IL-10 IL-17 IL-2 IL-6 IL-7 IL-8 ill patient immune response immune system Increasing Infection inhibiting interleukin MCP-1 monocyte Necrosis occur pathogenesis of COVID-19 Protein respiratory Respiratory system response role SARS-CoV-2 SARS-COV-2 infection target Th1 Th17 Th17 cell Th17 pathway Th17 response Th2 responses the SARS-CoV-2 virus therapeutic intervention TNF Treg cells viral infection with COVID-19 [DOI] 10.3390/cells10061550 PMC 바로가기 [Article Type] Review
COVID-19 and RA share an SPP1 myeloid pathway that drives PD-L1 + neutrophils and CD14 + monocytesCOVID-19와 RA는 PD-L1 + 호중구 및 CD14 + 단핵구를 구동하는 SPP1 골수성 경로를 공유합니다Research Article Published on 2021-06-182022-09-10 Journal: JCI Insight [Category] MERS, 바이오마커, [키워드] Activation alveoli appear Arthritis Autoimmune diseases BALF Bronchoalveolar lavage fluid cause CD14 CD48 Chronic inflammatory arthritis Cluster Concentration COVID-19 COVID-19 pathogenesis disease driven by FABP4 FCN1 hallmark healthy high plasma levels IHC Infectious disease Inflammation innate response intensive care unit investigation lung Macrophage macrophage cluster macrophage clusters macrophages mechanism mediators monocyte Monocytes myeloid cell neutrophil Neutrophils pathogenic pathology pathway PD-L1 plasma plasma concentrations Pneumonitis predicted Predictive predominant proinflammatory remained rheumatoid arthritis S100A12 severe COVID-19 severe pneumonia SPP1 synovial synovitis tissue trajectory transcriptionally transfer TREM2 unique upstream [DOI] 10.1172/jci.insight.147413 PMC 바로가기 [Article Type] Research Article
Monocyte Distribution Width (MDW) as novel inflammatory marker with prognostic significance in COVID-19 patientsCOVID-19 환자에서 예후의 중요성을 가진 신규 염증 마커로서 단핵구 분포 폭 (MDW)Observational Study Published on 2021-06-162022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 바이오마커, 임상, [키워드] 95% CI Activation analyzed Biomarker Biomarkers Cell change clinical impact Clinical severity Cohort correlated correlation COVID-19 patient COVID-19 patients CRP cytokine Cytokine storm cytometric disorder ferritin fibrinogen hematologic hospital immunology Immunopathogenesis Inflammatory inflammatory cell inflammatory disorder inflammatory markers life-threatening management marker mediators Microbiology monocyte Monocyte activation Monocytes outcome parameter pilot study prognostic sensitivity Sepsis severe COVID-19 specificity subset threshold to define turn width [DOI] 10.1038/s41598-021-92236-6 PMC 바로가기 [Article Type] Observational Study
Long‐lived macrophage reprogramming drives spike protein‐mediated inflammasome activation in COVID‐19Article Published on 2021-06-162022-11-01 Journal: EMBO Molecular Medicine [Category] COVID-19, MERS, SARS, [키워드] adaptive cause convalescent COVID‐19 COVID‐19 patient COVID‐19 patients Epigenetic gene expression signature healthy hyperinflammation Hyperinflammatory syndrome Immunity immunology in vivo Inflammasome inflammasome activation Innate innate immune innate immune memory Innate immunity longitudinal analysis Macrophage Microbiology, Virology & Host Pathogen Interaction Modification monocyte naïve individuals NLRP3 patients responsible resulting robust SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 secretion Signaling Spike protein subset Surface glycoprotein transcriptional Trigger vaccine antigen viral control [DOI] 10.15252/emmm.202114150 PMC 바로가기 [Article Type] Article
Plasma from patients with bacterial sepsis or severe COVID-19 induces suppressive myeloid cell production from hematopoietic progenitors in vitroResearch Article Published on 2021-06-162022-10-29 Journal: Science Translational Medicine [Category] COVID-19, MERS, SARS, [키워드] Bacterial Bacterial sepsis Blood Bone marrow CD14 Cell cell subpopulation cells cellular clinical manifestation correlated COVID-19 CRISPR-Cas9 Culture cytokine cytokines IL-6 datasets demonstrated dysregulation expression Factor Gene Expression healthy IL-10 IL-6 immunosuppressive in vitro in vitro study induce monocyte MS1 myeloid myeloid cell neutrophil Patient plasma plasma concentration progenitor cell receptor reported RNA SARS-COV-2 infection Sepsis severe COVID-19 severe COVID-19 patient severe infections severity systemic cytokine transcriptomics Treatment up-regulated [DOI] 10.1126/scitranslmed.abe9599 PMC 바로가기 [Article Type] Research Article
Mucosal-associated invariant T cell responses differ by sex in COVID-19COVID-19에서 점막 관련 불변 T 세포 반응은 성별에 따라 다릅니다Article Published on 2021-06-112022-09-11 Journal: Med (New York, N.Y.) [Category] MERS, 유전자 메커니즘, 임상, 진단, [키워드] aerosol Affair airway Apoptosis biosafety level BSL-2 BSL-3 carried Cell cells from male circulating construction content contribute coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 sample COVID-19 samples COVID-19 susceptibility DARPA dataset Duke early infection female females flow cytometry gene signature healthy control Hospitalized IL-7 immune response immune responses immunologically individual Innate immunity integration level 2 management mechanism monocyte mononuclear cell mononuclear cells outcomes Peripheral blood Peripheral blood mononuclear cells pro-apoptotic processed Protective Quality Quality assurance reduced reduction Regional Biocontainment Laboratory responsibility SARS-CoV-2 Sex sexual dimorphism sexual dimorphisms Single-cell RNA sequencing Support supported System T cell response tissue uninfected veteran Virology [DOI] 10.1016/j.medj.2021.04.008 PMC 바로가기 [Article Type] Article