Somatic Genetics Empowers the Mouse for Modeling and Interrogating Developmental and Disease ProcessesSomatic Genetics는 발달 및 질병 과정을 모델링하고 조사하기 위해 마우스를 강화합니다Review Published on 2011-07-212022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accelerated be applied disease Disease progression Gene Genetic genetics genomic human biology human disease humanized in vivo mapped modeling mouse Mutagenesis Mutation pathway Pathways resource rodents Somatic therapeutic intervention to screen transposon [DOI] 10.1371/journal.pgen.1002110 PMC 바로가기 [Article Type] Review
PLP2 of Mouse Hepatitis Virus A59 (MHV-A59) Targets TBK1 to Negatively Regulate Cellular Type I Interferon Signaling PathwayResearch Article Published on 2011-02-182022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] Activation acute respiratory syndrome assays catalytic domain cells cellular complex conserved coronavirus cytoplasm deubiquitinase domain dose-dependent manner DUB ENCODE Evidence experiment finding identification IFN IFN signaling IFN signaling pathway IFN transcription IFN-β in vitro inactivated inactive Infection inhibit inhibited innate immune system IRF3 MHV-A59 mouse mouse hepatitis virus nonstructural protein 3 Nsp3 nuclear translocation overexpression Papain-like protease phosphorylate PLP2 Prevent principal Proteins receptor reduced Regulatory Replication reporter shown Spread supported target TBK1 TNF TRAF3 Treatment Type type I interferon upstream [DOI] 10.1371/journal.pone.0017192 PMC 바로가기 [Article Type] Research Article
CXCR2 Signaling Protects Oligodendrocytes and Restricts Demyelination in a Mouse Model of Viral-Induced DemyelinationResearch Article Published on 2010-06-282022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] activating affected Apoptosis apoptotic cell BCL-2 binding caspase 3 Cell chemokine chronic infection cleavage cleaved clinical recovery CNS Culture CXCL1 CXCL2 CXCR2 decrease Demyelination disease elevated expression finding functional highlight increase in independent Infected Infection Inflammatory initiated inoculation Ligand Lineage mice Model modulation mouse mouse hepatitis virus Multiple Neuroinflammation neutralization neutralizing antiserum Oligodendrocyte pathology receptor sclerosis severity Signaling significantly susceptible sustained transcript viral infection [DOI] 10.1371/journal.pone.0011340 PMC 바로가기 [Article Type] Research Article
Crystal Structure of the C-Terminal Cytoplasmic Domain of Non-Structural Protein 4 from Mouse Hepatitis Virus A59Research Article Published on 2009-07-102022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] Amino acid asymmetric unit C-terminal complex conformation conserved coronavirus Coronavirus replication crystal crystal structure cytoplasmic cytosol determined different dissociate disulfide bond domain Endoplasmic reticulum ER membrane expressed feature finding functional hydrophilic infected cells membrane membrane vesicle MHV monomer mouse mutant N- and C-termini non-structural proteins not affect Nsp3 nsp4 opposite physiological recruited reducing Region Replication Ser shown Structure wild-type [DOI] 10.1371/journal.pone.0006217 PMC 바로가기 [Article Type] Research Article
Germinal centre and marginal zone B cells expand quickly in a second Plasmodium chabaudi malaria infection producing mature plasma cells생식 중심과 변연대 B 세포는 두 번째 Plasmodium chabaudi 말라리아 감염에서 빠르게 확장되어 성숙한 플라스마 세포를 생성합니다.Original Article Published on 2009-01-012024-08-26 Journal: Parasite Immunology [Category] 말라리아, [키워드] B lymphocyte Immunological memory malaria mouse [DOI] 10.1111/j.1365-3024.2008.01066.x PMC 바로가기 [Article Type] Original Article
Mouse Hepatitis Coronavirus RNA Replication Depends on GBF1-Mediated ARF1 ActivationResearch Article Published on 2008-06-132022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] Activation ADP-ribosylation Analysis ARF ARF1 association Author cells cellular cellular pathway characteristic complex connection coronavirus Coronavirus replication Critical demonstrated dominant-negative downstream Endoplasmic reticulum Express expression Factors GBF1 GTPase GTPases guanine Host Human induce infected cell Infection inhibited inhibiting interfere involved knockdown MDCK cells membrane MHV Microscopy mouse mouse hepatitis mutant nucleotide observation provide Quantitative reduced Replication replication complex required RNA RNA virus secretory pathway significantly siRNA siRNAs structures target vesicles viruses [DOI] 10.1371/journal.ppat.1000088 PMC 바로가기 [Article Type] Research Article
Chimeric coronavirus-like particles carrying severe acute respiratory syndrome coronavirus (SCoV) S protein protect mice against challenge with SCoVArticle Published on 2007-12-262023-06-15 Journal: Vaccine [Category] MERS, [키워드] mouse neutralizing antibody SARS Coronavirus virus-like particles [DOI] 10.1016/j.vaccine.2007.11.092 PMC 바로가기 [Article Type] Article