Spike protein-independent attenuation of SARS-CoV-2 Omicron variant in laboratory miceArticle Published on 2022-09-132022-11-16 Journal: Cell Reports [Category] SARS, 변종, [키워드] accompanied ACE2 acute respiratory syndrome attenuation. BALB/c mice cause coronavirus CP: Microbiology disease disease severity Interaction K18-hACE2 Laboratory mice Mutation omicron Omicron variant pseudovirus responsible robust SARS-CoV-2 spike Spike protein the receptor-binding domain the spike protein variant variants of concern Viral load virus [DOI] 10.1016/j.celrep.2022.111359 PMC 바로가기
SARS-CoV-2 omicron variant clearance delayed in breakthrough cases with elevated fasting blood glucoseArticle Published on 2022-09-132022-11-16 Journal: Virology Journal [Category] SARS, 변종, [키워드] Administered Analysis B.1.1.529 baseline CD4 CD8 clearance collected correlated COVID-19 demographic dominant variant dose elevated epidemiological data fasting blood Fever Glucose Inactivated vaccine independent risk factor injection Logistic lymphocyte median omicron Omicron variant Patient Platelet positively correlated risk factor RNA SARS-CoV-2 SARS-CoV-2 RNA Symptom T cell T lymphocyte undetectable uric acid Vaccine vaccine injection variant viral clearance [DOI] 10.1186/s12985-022-01877-0 PMC 바로가기
Surface Inactivation of Highly Mutated SARS-CoV-2 Variants of Concern: Alpha, Delta, and OmicronArticle Published on 2022-09-122022-11-16 Journal: Biomacromolecules [Category] SARS, 변종, [키워드] adaptive Alpha Antiviral Complete Degradation Delta dominant effective Evolution Face mask glycosylated inactivation independent induce Infection ingestion Mask mice mutations non-toxic omicron Omicron variant pandemic physical barrier Polymer reduction SARS-CoV-2 SARS-CoV-2 transmission Spike protein Spread surface Transmission Vaccine variant variants variants of concern viral genome viral membrane virion virulence virus VoC VOCs waning immunity [DOI] 10.1021/acs.biomac.2c00801 PMC 바로가기
Variation of Proteolytic Cleavage Sites towards the N-Terminal End of the S2 Subunit of the Novel SARS-CoV-2 Omicron Sublineage BA.2.12.1Article Published on 2022-09-082022-11-16 Journal: Molecules [Category] SARS, 변종, [키워드] accompanied Activation amino acid substitution BA.2.12.1 binding cathepsin G Cell cleavage site cleaved complex COVID-19 digested End furin immune response Infection MHC modify neutrophil Neutrophil elastase Neutrophils novel omicron Omicron variant Pathogens peptide polybasic Prevalence priming protease Protein proteinase proteinase 3 S1/S2 S2 antigen S2 subunit SARS-CoV-2 SARS-CoV-2 variant secrete sequence serine protease serine proteases Site Support T cell activation the major histocompatibility the S protein the Spike TMPRSS2 viral entry [DOI] 10.3390/molecules27185817 PMC 바로가기
SARS-CoV-2 infection in pediatric population before and during the Delta (B.1.617.2) and Omicron (B.1.1.529) variants eraArticle Published on 2022-09-082022-11-16 Journal: Virology Journal [Category] SARS, 변종, [키워드] Affect Asymptomatic available data B.1.1.529 B.1.617.2 caused children clinical manifestation clinical manifestations Complication conditions coronavirus disease country COVID-19 Delta delta variant Direct drastic exacerbating Google Scholar Health highest highlight Hospitalization immune response Immunodepressive incidence Infant Infants infected children Infection Manifestations Mild MIS MIS-C occur omicron Omicron variant pandemic pediatric Prevalence prevalence of COVID-19 proportion reported Risk factors SARS-COV-2 infection Science suggested symptomatic SARS-CoV-2 infection Symptoms the United State Transmission dynamics vaccination variant variants virulent [DOI] 10.1186/s12985-022-01873-4 PMC 바로가기
Serial infection with SARS-CoV-2 Omicron BA.1 and BA.2 following three-dose COVID-19 vaccinationArticle Published on 2022-09-062022-11-15 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, [키워드] activity average characterized Cohort COVID-19 COVID-19 vaccination dose highlight humoral Humoral immunity Humoral response IgG Immunity immunologically individual Infection infection with SARS-CoV-2 infections laboratory-confirmed measure of BNT162b2 omicron Omicron variant PROTECT Protective Reinfection response SARS-CoV-2 severe disease Vaccine vaccine doses vaccine-induced immune response vaccinees variant Virus neutralization wild-type [DOI] 10.3389/fimmu.2022.947021 PMC 바로가기
Relative Effectiveness of COVID-19 Vaccination in Healthcare Workers: 3-Dose Versus 2-Dose VaccinationArticle Published on 2022-09-052022-11-16 Journal: Journal of Korean medical science [Category] SARS, 변종, [키워드] 1:1 acute respiratory syndrome Analysis booster booster vaccination case-control study conducted controls coronavirus COVID-19 cross-reactive dose Effectiveness elapsed evade evaluate expected healthcare worker Immunity moderate mRNA vaccine Omicron variant positive relative SARS-CoV-2 SARS-CoV-2 test the vaccine vaccination vaccine effectiveness vaccine immunity [DOI] 10.3346/jkms.2022.37.e267 PMC 바로가기
Effect of Delta and Omicron Mutations on the RBD-SD1 Domain of the Spike Protein in SARS-CoV-2 and the Omicron Mutations on RBD-ACE2 Interface ComplexArticle Published on 2022-09-032022-11-16 Journal: International Journal of Molecular Sciences [Category] SARS, 변종, 유전자 메커니즘, [키워드] AABPU ACE2 Affect Amino acid atomic level bind Delta delta variant distributions domain Effect Efficacy help human ACE2 receptor Impact implication in-depth analysis information Interaction interactions interatomic interaction interface mechanism Mutation omicron Omicron variant partial charge. penetration RBD RBD mutation RBD-ACE2 RBD-ACE2 complex RBD-SD1 domain S-protein SARS-CoV-2 SARS-CoV-2 virus significantly increased specific mutation spike-protein the Spike Therapies Treatment Vaccine variant wild-type strain [DOI] 10.3390/ijms231710091 PMC 바로가기
The rapid spread of SARS-COV-2 Omicron variant in Italy reflected early through wastewater surveillance이탈리아에서 SARS-COV-2 Omicron 변종의 급속한 확산은 폐수 감시를 통해 조기에 반영Article Published on 2022-09-012022-09-11 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] characteristic collected country described detect diffusion Effectiveness Epidemiology European Commission followed by increase in Infection Italian population Italy Mutation North Occurrence omicron Omicron variant PCR amplicons positive Prevalence qPCR raising real-time RT-PCR reflected rising RT-PCR RT-PCR assay RT-qPCR Sanger sequencing SARS-CoV-2 SARS-CoV-2 variant Sequencing sewage South Africa spike gene Spread Surveillance territory tested variant Veneto was used Wastewater-based epidemiology [DOI] 10.1016/j.scitotenv.2022.155767 PMC 바로가기 [Article Type] Article
Comparison of the reactogenicity and immunogenicity of a reduced and standard booster dose of the mRNA COVID-19 vaccine in healthy adults after two doses of inactivated vaccineArticle Published on 2022-09-012022-10-05 Journal: Vaccine [Category] SARS, 변종, 유전자 메커니즘, 임상, 진단, 치료기술, [키워드] Antibody Response approved BNT162b2 booster booster dose clinical trial comparable CoronaVac coronavirus disease Coverage COVID-19 COVID-19 vaccine Delta diarrhea dose elicited groups headache healthcare healthy heterologous vaccine Inactivated vaccine joint mRNA mRNA vaccine mRNA-1273 vaccine omicron Omicron variant Pain pandemic reactogenicity reduced Reduced dose Result significant difference Standard dose the SARS-CoV-2 third dose Vaccine World Health Organization [DOI] 10.1016/j.vaccine.2022.08.033 [Article Type] Article