State variation in effects of state social distancing policies on COVID-19 casesResearch Article Published on 2021-06-282022-10-28 Journal: BMC Public Health [Category] COVID-19, MERS, SARS, [키워드] Community confidence COVID-19 COVID-19 case COVID-19 cases cumulative database death Effect Generalized linear model Health policy highest infection rate initial interval log NEB Negative binomial distribution New New York novel coronavirus disease Outcomes research predicted prevented public health reduction relative Result social distancing Spread state Study design supplementary material the United State time total effect Variation Washington [DOI] 10.1186/s12889-021-11236-3 PMC 바로가기 [Article Type] Research Article
The Safety of COVID-19 Vaccinations—We Should Rethink the PolicyArticle Published on 2021-06-242022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] 95% confidence interval Adverse Adverse drug reaction Adverse reaction benefit calculated COVID-19 COVID-19 vaccine database death drug EMA European Medicines Agency fatal side effects Government lack mRNA vaccine mRNA-vaccine number needed to vaccinate Pfizer Policy Prevent prevented reaction reported Result risk Safety SARS-CoV2 Side effect Side effects vaccinate vaccination Vaccinations [DOI] 10.3390/vaccines9070693 PMC 바로가기 [Article Type] Article
The Fc-mediated effector functions of a potent SARS-CoV-2 neutralizing antibody, SC31, isolated from an early convalescent COVID-19 patient, are essential for the optimal therapeutic efficacy of the antibody초기 회복기 COVID-19 환자로부터 분리 된 강력한 SARS-COV-2 중화 항체, SC31의 FC- 매개 이펙터 기능은 항체의 최적의 치료 효능에 필수적이다.Research Article Published on 2021-06-232022-08-13 Journal: PLoS ONE [Category] Biochemistry, MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] ACE2 addition Administered animal models Anti-SARS-CoV-2 Activity anti-viral immune responses antibody Antibody-dependent enhancement Antibody-mediated neutralization convalescent convalescent patient COVID-19 COVID-19 patient demonstrated dose-dependent efficacy effective Efficacy epitope evidenced exhibited Fc-mediated effector function Fc-mediated effector functions Fc-null LALA variant Histopathology IFNγ immune responses Inflammatory responses K18-human ACE2 transgenic mice LALA variant Lower respiratory tract lung Lungs mice neutralization ability Neutralizing antibodies neutralizing antibody occur preclinical studies preclinical study prevented pro-inflammatory response pro-inflammatory responses promote Protein Receptor-binding domain reduced viral load reduced viral loads reduction respiratory rhesus macaques SARS-CoV-2 SARS-CoV-2 neutralizing antibody SARS-CoV-2 spike protein SARS-CoV-2-infected hamsters SARS-CoV-2-neutralizing antibodies SARS-CoV-2-neutralizing antibody SC31 SC31 treatment severity of COVID-19 significantly spike Spike protein sub-therapeutic doses the receptor-binding domain the SARS-CoV-2 therapeutic therapeutic efficacy therapeutic potential Therapeutics transgenic mice treated treatment with SC31 undetectable Viral Viral load viral loads viral-induced viral-induced lung inflammatory responses weight loss [DOI] 10.1371/journal.pone.0253487 PMC 바로가기 [Article Type] Research Article
COVID-19 Vaccine Acceptance in Azuay Province, Ecuador: A Cross-Sectional Online SurveyArticle Published on 2021-06-212022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] acceptance age COVID-19 COVID-19 infection COVID-19 test COVID-19 vaccination COVID-19 vaccine COVID-9 Ecuador effective female Hesitancy indicated investigated knowledge participant participated prevented Side effect survey the vaccine thought vaccination Vaccine Vaccine acceptance [DOI] 10.3390/vaccines9060678 PMC 바로가기 [Article Type] Article
Assessing the efficacy and safety of hydroxychloroquine as outpatient treatment of COVID-19: a randomized controlled trialCOVID-19의 외래 환자 치료로서 하이드록시클로로퀸의 효능 및 안전성 평가: 무작위 대조 시험Randomized Controlled Trial Published on 2021-06-182022-09-11 Journal: CMAJ open [Category] SARS, 임상, 치료제, [키워드] 95% confidence interval Assessing assigned Chain Reaction Community Composite conducted Contact contact with Controlled trial COVID-19 COVID-19 pandemic death determine determined by did not reduce direct contact disposition effect of treatment Efficacy and safety eligible enrolment Evidence expected First wave Follow-up hazard ratio Hospitalization hospitalizations hospitalized patient hospitalized patients Hydroxychloroquine hydroxychloroquine group hydroxychloroquine treatment identification individual Invasive mechanical ventilation matching placebo mechanical ventilation Mortality outcome outcomes Outpatient outpatients participant Participants patients PCR test Placebo placebo group polymerase chain polymerase chain reaction positive RT-PCR Prevent prevented Primary outcome priority raised Randomized controlled trial Randomly reduced resulting reverse transcription reverse transcription polymerase chain reaction Ribonucleic acid RT-PCR Safety SARS-COV-2 infection secondary Secondary outcomes Serious Adverse Event Serious Adverse Events severe COVID-19 study drug survived symptom duration symptom onset the placebo group therapy Treatment Trial viral ribonucleic acid with COVID-19 [DOI] 10.9778/cmajo.20210069 PMC 바로가기 [Article Type] Randomized Controlled Trial
Controlling the pandemic during the SARS-CoV-2 vaccination rolloutArticle Published on 2021-06-162022-10-29 Journal: Nature Communications [Category] COVID-19, MERS, [키워드] activity Analysis Applied mathematics Computational models Consensus controlling Coverage COVID-19 COVID-19 pandemic effort Epidemiology Hospital admissions introduced knowledge measure pandemic Portugal prevented public health SARS-CoV-2 the SARS-CoV-2 Transmission model vaccination [DOI] 10.1038/s41467-021-23938-8 PMC 바로가기 [Article Type] Article
SARS-CoV-2 and the role of fomite transmission: a systematic reviewSARS-CoV-2와 매개체 전파의 역할: 체계적인 검토Systematic Review Published on 2021-06-142022-09-11 Journal: F1000Research [Category] MERS, SARS, 치료기술, [키워드] comparison Comparisons Concentration contaminated surface contaminated surfaces COVID-19 criteria cycle cycle threshold Cycle threshold values Cytopathic effect discrepancies discrepancy Dynamics estimation Evidence FIVE fomites Frequency Google Google Scholar healthcare heterogeneity highest hospital hygiene ICU identify Isolation Laboratory lack majority medRxiv methodology moderate open pathway positive Prevent prevented ranged reported Reporting Research Result review risk of transmission RT-PCR sample collection SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 test Study design systematic review systematic reviews tested threshold value Transmission Transmission dynamics transmissions transmitted Variation variations Ventilation Viral viral concentrations viral culture virus WHO [DOI] 10.12688/f1000research.51590.3 PMC 바로가기 [Article Type] Systematic Review
A benefit–cost analysis of different response scenarios to COVID ‐19: A case studyResearch Article Published on 2021-06-042022-11-01 Journal: Health Science Reports [Category] COVID-19, [키워드] adopted Analysis approach benefit calculated COVID COVID‐19 death Direct estimate excluded hospital Hospitalization hospitalizations Immunity Impact indicate International introduced less maximum Natural disaster pandemic policy making prevented public policy reached Result sick simulation modeling state unlikely virus [DOI] 10.1002/hsr2.286 PMC 바로가기 [Article Type] Research Article
Beneficial Effects of Mineralocorticoid Receptor Pathway Blockade against Endothelial Inflammation Induced by SARS-CoV-2 Spike ProteinArticle Published on 2021-06-032022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] abnormal coagulation Activation antagonist blockade complications COVID-19 patients downstream dysfunction Effect ELISA endothelial Endothelial cell endothelial cells galectin-3 induced Inflammation Inflammatory Inflammatory response inhibitor interferon-γ interleukin-6 involved marker Mineralocorticoid mineralocorticoid receptor monocyte chemoattractant protein-1 pathogenesis of COVID-19 pathway prevented Protein receptor recombinant S protein reduce reversed S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV2 secretion Signaling spike supernatant thrombosis treated were assessed western blotting [DOI] 10.3390/biomedicines9060639 PMC 바로가기 [Article Type] Article
Effects of COVID-19 on the admissions of aneurysmal subarachnoid hemorrhage: the West Greece experienceObservational Study Published on 2021-06-012022-10-05 Journal: Neurological Sciences [Category] SARS, 임상, [키워드] Admission admission rate Admitted Patient Aneurysm aneurysm. clinics conducted coronavirus disease 19 Coronavirus disease 19 (COVID-19) COVID COVID-19 COVID-19 pandemic Critical decrease difference Effect equipment Greece hemorrhage Hypothesis incidence increase in lockdown majority Mortality outcome Patient patients presenting prevented reductions in retrospective rupture single-center statistical significance statistically significant study cohort Subarachnoid subarachnoid hemorrhage Subarachnoid hemorrhage (SAH) surgical vascular disease Volume West [DOI] 10.1007/s10072-021-05190-6 PMC 바로가기 [Article Type] Observational Study