Mutagenic Effects of Ribavirin on Hepatitis E Virus—Viral Extinction versus Selection of Fitness-Enhancing MutationsReview Published on 2016-10-132023-05-23 Journal: Viruses [Category] E형 간염, Fulltext, [키워드] hepatitis E virus intra-host population Mutagenesis ribavirin RNA viruses [DOI] 10.3390/v8100283 PMC 바로가기 [Article Type] Review
Genetic Drift, Purifying Selection and Vector Genotype Shape Dengue Virus Intra-host Genetic Diversity in Mosquitoes모기의 유전적 드리프트, 정제 선택 및 벡터 유전자형 모양 뎅기열 바이러스 숙주 내 유전적 다양성Research Article Published on 2016-06-152022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] acting Adaptability adaptive addition alteration anatomical Arboviruses arthropod vector arthropod vectors arthropod-borne breadth Critical deep sequencing deleterious mutation Deleterious mutations Dengue dengue virus dengue viruses Diversity drift effective Evolution Factor fitness fluctuation full-length Genetic genetic background genetic diversity genetic drift genetic factors genetic heterogeneity genomes Genotype High-throughput sequencing host infection identifying Infection initial maintenance midgut infection MONITOR Mosquito natural natural selection Population population bottleneck population bottlenecks Population size populations provide purging Purifying random Randomly reduce reductions in Replication resulting RNA virus RNA viruses Selection Sequencing shape significantly the mosquito variant vector vectors Viral viral genome viral genomes virus virus genomes viruses wild-type [DOI] 10.1371/journal.pgen.1006111 PMC 바로가기 [Article Type] Research Article
High-Resolution Analysis of Coronavirus Gene Expression by RNA Sequencing and Ribosome ProfilingResearch Article Published on 2016-02-262022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] applicability approach Betacoronavirus carried Cell coronavirus Coronaviruses Course culture cell deep sequencing determine digestion Efficiency epidemic diarrhea family Coronaviridae feature Frame frameshift Gene Expression Genome genomic high mortality rate Host host-virus interactions identify Infection investigated knowledge living cell mapped member MERS-CoV MHV MHV-A59 Middle East MONITOR mouse hepatitis virus mRNA mRNAs murine nucleotide Open reading frame open reading frames ORF ORFs Other pandemic Pathogens polyprotein positive pp1a Precision Profiling profiling analysis PROTECT purified regions Regulation Regulatory Replication ribosome RNA RNA sequencing RNA virus RNA viruses SARS-CoV sensitivity tissue transcript Transcription Transcriptome transcripts translated translation translational Triplet upstream viral mRNA Viral RNA virus was performed [DOI] 10.1371/journal.ppat.1005473 PMC 바로가기 [Article Type] Research Article
Genomic Analysis and Surveillance of the Coronavirus Dominant in Ducks in ChinaResearch Article Published on 2015-06-082022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] cellular China circulating conserved coronavirus deletions demonstrated distribution dominant duck ecological niches Evolution frameshift genetic diversity Genome homologous insertions Lineage occurred Organisms performed prevalent Protein recombination event Region RNA viruses RT-PCR assay sequenced substitutions Surveillance viral genome [DOI] 10.1371/journal.pone.0129256 PMC 바로가기 [Article Type] Research Article
Coronavirus nonstructural protein 1: Common and distinct functions in the regulation of host and viral gene expressionArticle Published on 2014-11-262022-11-01 Journal: Virus research [Category] Coronavirus, [키워드] accumulating acute respiratory syndrome antiviral responses biological function common conserved coronavirus CoV CoV infection CoVs determine downregulation Evidence Factor function functional highly pathogenic Host host gene expression human coronavirus inhibit innate immune response knowledge mammalian Middle East modulate mRNA cleavage nonstructural protein 1 novel nsp1 Pathogenesis Protein provide Regulation RNA viruses SARS SARS Coronavirus syndrome translation inhibition unique Vaccine development viral gene expression Viral protein virulence [DOI] 10.1016/j.virusres.2014.11.019 PMC 바로가기 [Article Type] Article
Spherules and IBVCommentary Published on 2014-09-012022-10-27 Journal: Bioengineered [Category] Coronavirus, [키워드] bronchitis candidate cell interaction cellular membrane complexes coronavirus cross-protection Culture cultured cells double membrane vesicles Ex vivo IBV identify infecting Infection Infectious Bronchitis Virus membrane membrane rearrangements organ positive primary cell replication site Research RNA virus RNA viruses spherule spherules Structure Vaccine Variation Viral protein virus virus attenuation virus replication virus strain while [DOI] 10.4161/bioe.29323 PMC 바로가기 [Article Type] Commentary
Coronavirus reverse genetic systems: Infectious clones and repliconsArticle Published on 2014-06-122022-11-01 Journal: Virus research [Category] Coronavirus, [키워드] acute respiratory syndrome Analysis antiviral drugs approach Bacteria Central nervous system clone coronavirus CoV CoV genome CoV replication CoVs defined Diseases gene sequence Genetic genetics Human in vitro infect infectious clones Interaction limitations overcome Pathogenesis positive replicons reverse genetic system reverse genetics RNA viruses SARS-CoV Vaccine vaccinia virus [DOI] 10.1016/j.virusres.2014.05.026 PMC 바로가기 [Article Type] Article
Targeting Membrane-Bound Viral RNA Synthesis Reveals Potent Inhibition of Diverse Coronaviruses Including the Middle East Respiratory Syndrome VirusResearch Article Published on 2014-05-292022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] accompanied accumulating antiviral activity antiviral drug antiviral intervention cellular membrane complex component Compound concerning conserved Coronaviral coronavirus coronavirus 229E Coronavirus infection Coronavirus replication Coronaviruses Culture early phase epithelia genome replication hallmark highly pathogenic Host host cell cytoplasm implicated Including infections inhibit inhibition inhibitor knowledge membrane membrane vesicle membrane-bound membranes MERS-CoV MERS–CoV Middle East mutant Mutation non-structural protein not affected positive potent raise recruitment reduced replicate Replication representing respiratory respiratory syndrome coronavirus RNA RNA synthesis RNA virus RNA viruses SARS-CoV screened Substitution synthesis target targeting Transcription Treatment viral life cycle viral replication viral RNA synthesis virus virus entry zoonotic [DOI] 10.1371/journal.ppat.1004166 PMC 바로가기 [Article Type] Research Article
Infectious Bronchitis Virus Generates Spherules from Zippered Endoplasmic Reticulum MembranesResearch Article Published on 2013-10-222022-10-29 Journal: mBio [Category] Coronavirus, MERS, [키워드] acute respiratory syndrome alphaviruses Betacoronavirus candidate Cell cell line cell types cellular cellular membranes characterized cisternae CM complex coronavirus Coronaviruses Culture cultures cytoplasm electron Endoplasmic reticulum epithelial cell Ex vivo generate IBV IBV infection IBV-infected cell in viral induce infected cells Infection Infectious Bronchitis Virus interior invagination lack mammalian cell mean membrane mouse hepatitis virus organ outer membrane pathogen platform positive-sense positive-sense single-stranded RNA related replication complexes Reticulum RNA RNA synthesis RNA virus RNA viruses SARS-CoV sealed spherule spherules Structure thought tissue tomography tracheal Vesicle viral replication Viral RNA virus [DOI] 10.1128/mBio.00801-13 PMC 바로가기 [Article Type] Research Article
HexaPrime: A novel method for detection of coronavirusesArticle Published on 2012-12-072022-11-01 Journal: Journal of virological methods [Category] Coronavirus, [키워드] addition adopted amplification assays cDNA synthesis conserved coronavirus Coronaviruses described develop diagnostic DNA effort etiological facilitate HexaPrime high variability human disease identify manuscript oligonucleotide overcome regions RNA fragment RNA virus RNA viruses sequence tested universal primer viral nucleic acid virus virus discovery viruses [DOI] 10.1016/j.jviromet.2012.11.039 PMC 바로가기 [Article Type] Article