COVID-19 Vaccines: A Review of the Safety and Efficacy of Current Clinical TrialsReview Published on 2021-04-252022-10-28 Journal: Pharmaceuticals [Category] COVID-19, [키워드] clinical clinical trial COVID-19 COVID-19 pandemic current Efficacy evaluate herd immunity Immunity populations Protective review risk Safety safety profile Side effect the vaccine vaccination Vaccine Vaccine development [DOI] 10.3390/ph14050406 PMC 바로가기 [Article Type] Review
Safety and immunogenicity of the SARS-CoV-2 BNT162b1 mRNA vaccine in younger and older Chinese adults: a randomized, placebo-controlled, double-blind phase 1 study Research Published on 2021-04-222022-10-05 Journal: Nature Medicine [Category] SARS, 임상, 진단, [키워드] acute respiratory syndrome Adults adverse event Asian BNT162b1 China Chinese clinical investigation convalescent coronavirus COVID-19 domain dose double-blind effective ENCODE event geometric healthy human sera humoral immunogenicity data interferon-γ Jiangsu local reaction Mild moderate mRNA vaccine Neutralizing titer Older pandemic parallel-group participant Participants peptide pool phase 1 study phase 1 trial Placebo placebo-controlled polymerase chain positive prime and boost Randomized RBD reached receive response robust Safety safety profile SARS-CoV-2 single-center spike glycoprotein the RBD the SARS-CoV-2 the vaccine Tolerability treatment group vaccination Vaccine vaccine candidate [DOI] 10.1038/s41591-021-01330-9 [Article Type] Research
Immunomodulating Effects of Fungal Beta-Glucans: From Traditional Use to MedicineReview Published on 2021-04-172022-10-30 Journal: Nutrients [Category] Coronavirus, MERS, SARS, [키워드] addition approved Chinese claimed COVID-19 Defense dietary supplement Effect Effects Efficacy element European Evidence example fungal Guidance Health health claims help immune stimulation immune system Immunity immunological immunomodulating immunomodulation insight investigated Medicine Mushrooms nutrition pathogen response safety profile shown Traditional [DOI] 10.3390/nu13041333 PMC 바로가기 [Article Type] Review
Case Report: Complete and Fast Recovery From Severe COVID-19 in a Pemphigus Patient Treated With Rituximab사례 보고서: 리툭시맙으로 치료받은 천포창 환자의 중증 COVID-19에서 완전하고 빠른 회복Case Reports Published on 2021-04-162022-09-12 Journal: Frontiers in Immunology [Category] MERS, 진단, [키워드] acute respiratory syndrome autoantibody Autoimmune autoimmune blistering disease Autoimmune disease B cell B-cell blistering caused Cell characterized clinician components condition corticosteroid treatment COVID-19 COVID-19 pandemic disease effective Immunosuppression induce Infection infections inflammatory phase involved management mucous membrane outcome pandemic Patient pemphigus raised risk rituximab RTX safety profile severe pulmonary disease susceptibility Therapies Topic Treatment [DOI] 10.3389/fimmu.2021.665522 PMC 바로가기 [Article Type] Case Reports
Cardiotoxic Potential of Hydroxychloroquine, Chloroquine and Azithromycin in Adult Human Primary Cardiomyocytes성인 인간 원발성 심근세포에서 Hydroxychloroquine, Chloroquine 및 Azithromycin의 심장독성 가능성Article Published on 2021-04-122022-09-11 Journal: Toxicological sciences : an official journal of th [Category] SARS, 치료제, [키워드] adult human primary cardiomyocyte Azithromycin cardiac toxicity caused changed Channel block Chloroquine Clinical studies clinical study Combination Concentration concentrations contractility coronavirus coronavirus disease COVID-19 develop drug Effect effort elevated elevated temperature evaluated exhibiting Features high risk Human humans Hydroxychloroquine impacted Inflammatory diseases malaria mechanism medications Potential proarrhythmia risk promoted repurposed therapies risk safety profile therapeutic therapy translation translational Treatment [DOI] 10.1093/toxsci/kfaa194 PMC 바로가기 [Article Type] Article
The C-Terminal Domain of Nef mut Is Dispensable for the CD8 + T Cell Immunogenicity of In Vivo Engineered Extracellular VesiclesArticle Published on 2021-04-122022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] Antigen C-terminal C-terminus CD8 CD8+ T cell immunity cells deleted diffusion distal DNA DNA immunization effective elicit EVs expressing Extracellular Extracellular vesicles full-length fused Heterologous HIV-1 Nef HPV vaccines humans immune response Immunity immunogenicity injection isoform MOST not affect Perspective preserved Protein released S1 and S2 safety profile SARS-CoV-2 SARS-CoV-2 vaccines stability T cell translation tumor antigen Vaccine vaccine platform vector Vesicle [DOI] 10.3390/vaccines9040373 PMC 바로가기 [Article Type] Article
COVID-19 Vaccines: Current Understanding on Immunogenicity, Safety, and Further ConsiderationsCOVID-19 백신: 면역원성, 안전성 및 추가 고려 사항에 대한 현재 이해Review Published on 2021-04-122022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 신약개발, [키워드] analyzed candidate clinical testing country COVID-19 COVID-19 pandemic COVID-19 vaccine COVID-19 vaccines current effective Efficacy Evaluating expected First wave global pandemic highlight immunogenicity improvement intensity lockdowns reference standard Region respond Safety safety profile second wave significantly higher understanding vaccination Vaccine vaccine candidate Vaccines [DOI] 10.3389/fimmu.2021.669339 PMC 바로가기 [Article Type] Review
Assessment of the Safety and Therapeutic Benefits of Convalescent Plasma in COVID-19 Treatment: A Systematic Review and Meta-AnalysisMedicine Published on 2021-04-062022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] 95% confidence interval administration adverse event adverse events ARMS assessment baseline caused Characteristics clinical trial clinical trials Complete Concomitant medication contributed Controlled trial convalescent plasma coronavirus disease COVID-19 database death defined demographics disease severity effective therapy Effectiveness Efficacy eligibility criteria evaluate Evidence Frequency Health heterogeneity Hospitalization hospitalized COVID-19 patients Intervention item Meta-analysis methodological Mortality mortality rate neutralizing antibody non-randomized trial overall mortality Participants Patient plasma Primary outcome protocol RCT reduce mortality reduced viral load reducing reducing mortality Registered Reporting respiratory retrieved review Safe Safety safety profile SARS-CoV-2 severity significantly suffered the patient Therapeutic approach therapeutic potential therapy transfusion-related adverse events treat treated treated patient Trial trials viral clearance was performed [DOI] 10.3389/fmed.2021.660688 PMC 바로가기 [Article Type] Medicine
Leflunomide an immunomodulator with antineoplastic and antiviral potentials but drug-induced liver injury: A comprehensive review항종양 및 항바이러스 잠재력을 갖지만 약물 유발 간 손상을 갖는 레플루노마이드 면역조절제: 포괄적인 검토Review Published on 2021-04-012022-09-11 Journal: International immunopharmacology [Category] SARS, 임상, 치료제, [키워드] affected Anti-inflammatory Antineoplastic Antiviral antiviral activity approved Arthritis Autoimmune benefit Bilirubin Biomarkers catalytic Cell cell growth cellular Combination Compound COVID-19 Cytokines de novo synthesis DHODH drug drug-induced Drug-induced liver injury enzyme event growth hepatic impairment hepatic injury Immunoglobulin immunological immunomodulator Immunosuppression inhibit inhibitors joint destruction leflunomide Leflunomide. liver liver enzyme liver enzymes Liver injury membrane mitochondrial nucleotide nucleotides off-label outcome Pathogenesis pathophysiology Patient Perspective pharmacological precautions proliferation Protective Protein pyrimidine reducing Regulatory Relapsing-Remitting Multiple Sclerosis reported required responsible Rheumatoid safety profile SARS CoV SARS CoV-2 serum Treatment Trial tyrosine with COVID-19 [DOI] 10.1016/j.intimp.2021.107398 PMC 바로가기 [Article Type] Review
Mortality and Readmission Rates Among Patients With COVID-19 After Discharge From Acute Care Setting With Supplemental OxygenResearch Published on 2021-04-012022-10-29 Journal: JAMA Network Open [Category] COVID-19, MERS, SARS, [키워드] 95% CI Admission age all-cause mortality all-cause mortality rate ambulatory Analysis approach Care Cohort cohort study COVID-19 COVID-19 pandemic Critical death Department discharge discharged equipment expected female finding Follow-up follow-up time help Hospital admission Importance indicated interquartile range Los Angele male management measure median Medicaid Mortality Nurse objective occurred outcome outcomes oxygen participant Patient patients died patients with COVID-19 Pneumonia Point Practice provided Public Hospital quarantine Rate readmission receiving Relevance resources Result retrospective cohort study safety profile service setting Treatment [DOI] 10.1001/jamanetworkopen.2021.3990 PMC 바로가기 [Article Type] Research