tissue damage – Page 23 – Communicable Diseases Research

Development of the full-length cDNA clones of two porcine epidemic diarrhea disease virus isolates with different virulence

Research Article

Published on 2017-03-162022-10-28
Journal: PLoS ONE [Category] Coronavirus,

Analysis of the human monocyte-derived macrophage transcriptome and response to lipopolysaccharide provides new insights into genetic aetiology of inflammatory bowel disease

인간 단핵구 유래 대식세포 전사체 및 지질다당류에 대한 반응 분석은 염증성 장 질환의 유전적 병인에 대한 새로운 통찰력을 제공합니다

Research Article

Published on 2017-03-062022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] 48 hours Activation adaptation aetiology Analysis appearance arise Arthritis Bacteria Bacterial bacterial cells bacterial lipopolysaccharide bacterial stimuli Blood CAGE CAGE-based transcriptional profiling candidate candidate gene Candidates cascade Cell cells chronic inflammatory bowel diseases Cluster colony-stimulating factor complex component components Course Crohn’s disease CSF1 CSF1-dependent monocyte-macrophage transition CSF1-dependent monocyte-macrophage transitions Defense differentiation dysregulation enhancer enhancers eRNA transcription Families form function gastrointestinal mucosa Gene Expression Genetic genetic risk Genome genome-wide association Genome-wide association studies Gut gut wall GWA human cell human cells human monocyte human monocyte-derived macrophage human monocyte-derived macrophages hypothesised IBD IBD loci identify Immune cell immune cells Inflammatory bowel disease inflammatory bowel diseases inflammatory disease inheritance initiate inflammation intestinal lamina propria intestine involved lipopolysaccharide loci locus long non-coding RNA LPS Macrophage macrophage colony-stimulating factor macrophage differentiation macrophages majority MARA modulate monocyte monocyte differentiation monocyte-derived macrophage monocyte-specific genes Monocytes motif motif activity response analysis Pathogens positive produced promoter promoters provide Region regulated Regulation Regulatory responsible rheumatoid arthritis shown successive wave successive waves Support susceptibility susceptibility loci These data this system tissue damage tissues traits transcription factor transcription factors transcriptional activation transcriptional regulation Transcriptome transcriptome dataset transcripts transient gene expression ulcerative colitis utilised wall
[DOI] 10.1371/journal.pgen.1006641 PMC 바로가기 [Article Type] Research Article

Remote Control of Intestinal Stem Cell Activity by Haemocytes in Drosophila

초파리의 혈구에 의한 장 줄기 세포 활동의 원격 제어

Research Article

Published on 2016-05-272022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] activate activated Activation activity Bacterial infection blood cell Blood cells canonical cell proliferation circulating contribute Control Coordinate Critical Defense Drosomycin Drosophila Express expression fat Gut haemocyte haemocytes Host receptors Immunity indicate induce Inflammation Injury Innate Interaction intestinal epithelium intestinal stem cell intestine involved JAK/STAT JAK/STAT pathway JNK pathway lipopolysaccharide liver mammals mode multiple tissues Mutation oral bacterial infection organ Organisms overcome pathway peptidoglycan Previous studies previous study proliferation promote recognize Regulation released remote required reveal secreted molecule secreted protein secreted proteins septic injury signaling pathway STAT STEM stem cell stimulate suggested survival systemic immune response tissue damage tissue repair turn Upd Upd1 Upd2 Upd3 Upds while wound
[DOI] 10.1371/journal.pgen.1006089 PMC 바로가기 [Article Type] Research Article

Requirements for Pseudomonas aeruginosa Acute Burn and Chronic Surgical Wound Infection

녹농균 급성 화상 및 만성 외과적 상처 감염에 대한 요건

Research Article

Published on 2014-07-242022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] a major accompanied acute and chronic infections acute and chronic P. aeruginosa wound infections acute and non-diabetic chronic wound infections acute burn wound infections acute infection acute infections acute wounds addition amino acids Bacterial bed sores Burn burn wound burn wound infections burns carbon carbon source caused chemotactic chemotaxis chronic chronic and acute wounds chronic infection chronic infections chronic wound chronic wound infections cofactor cofactors colonization complex Critical determinant diabetic ulcers energy expression Fatty acid fatty acids fitness flagellar function Gene Expression Gene expression profiling Genetic genomic growth healthcare high mortality High-throughput sequencing in vivo Infection infections insertion Intensive Intervention metabolic genes murine model murine models mutant non-diabetic chronic wound infection non-diabetic chronic wound infections not correlated nutritional requirements opportunistic infection opportunistic Infections opportunistic pathogen P. aeruginosa P. aeruginosa wound infections pathogen Pathogenesis persistence power primary source profiles Pseudomonas aeruginosa purines Requirement RNA-Seq Sepsis Sequencing Soft tissue Soft tissue infections Spread Strains Surgical Wound Infection These data tissue damage Tn-seq trajectory Transcriptome Travel utility Variation virulence while Wound Infection wound infections
[DOI] 10.1371/journal.pgen.1004518 PMC 바로가기 [Article Type] Research Article

Monocyte and macrophage differentiation: circulation inflammatory monocyte as biomarker for inflammatory diseases

단핵구 및 대식세포 분화: 염증성 질환에 대한 바이오마커로서의 순환 염증성 단핵구

Review

Published on 2014-01-072022-08-07
Journal: Biomarker Research [Category] Biochemistry,

[키워드] Biomarker broad spectrum cardiovascular diseases changes circulation dendritic cells environmental stimulation express various receptors functional phenotype heterogeneity heterogeneous human disease Indicator Infection inflammatory disease Inflammatory diseases inflammatory monocyte inflammatory monocyte subset inflammatory monocyte subsets inflammatory or anti-inflammatory knowledge Macrophage macrophages MONITOR monocyte monocyte differentiation monocyte heterogeneity Monocytes monocytosis murine potential mechanism rapid progress recruited Research subset suggested tissue tissue damage tissue macrophage tissue macrophages various inflammatory diseases
[DOI] 10.1186/2050-7771-2-1 PMC 바로가기 [Article Type] Review

MMP-independent role of TIMP-1 at the blood brain barrier during viral encephalomyelitis

Research Article

Published on 2013-10-242022-10-28
Journal: ASN NEURO [Category] Coronavirus,

[키워드] accumulate BBB, blood brain barrier Blood brain barrier CD4 CD4 T cells CD8 Central nervous system chemokine CNS CNS, Central Nervous System coronavirus decrease disease severity EAE, experimental autoimmune encephalitis Encephalitis expression facilitate Glia glia limitans IFNγ, interferon γ IFNγ induce Infection Infectious virus Inflammatory response interferon γ limitans mAb, monoclonal antibody matrix metalloproteinase matrix metalloproteinases MHV, mouse hepatitis virus mice Migration MMP, matrix metalloproteinase neurotropic not affected Pathogenesis perivascular perivascular cuff PFA, paraformaldehyde recruitment reduced responsible suggested T cell T cell subset T cells TIMP-1 TIMP, tissue inhibitor of matrix metalloproteinases tissue damage Tissue Inhibitor virus WT, wild-type
[DOI] 10.1042/AN20130033 PMC 바로가기 [Article Type] Research Article

IFN-γ protects from lethal IL-17 mediated viral encephalomyelitis independent of neutrophils

Research

Published on 2012-05-292022-10-30
Journal: Journal of Neuroinflammation [Category] Coronavirus,

[키워드] affecting Autoimmune blockade CD4 CD4⁺ T cells Central nervous system clinical consequence CNS compared complex coronavirus cytokine Demyelination detrimental disease downstream effector molecule Encephalomyelitis expression Factor feedback loops GM-CSF IFN-γ IFN-γ IL-17 independent Infected inflammatory condition inflammatory disease Interaction mechanism memory mice morbidity Mortality murine Neurotropic coronavirus neutrophil neutrophil infiltration Neutrophils not express pathogenic positive PROTECT provided recipient reduced reducing relative contribution rescued response Result survival T cell T cells Th1 Th17 Th17 cell tissue damage Transcription transcriptional regulation transfer upregulation virus was used wild-type
[DOI] 10.1186/1742-2094-9-104 PMC 바로가기 [Article Type] Research

Programmed Death (PD)-1-Deficient Mice Are Extremely Sensitive to Murine Hepatitis Virus Strain-3 (MHV-3) Infection

Research Article

Published on 2011-07-072022-10-29
Journal: PLoS Pathogens [Category] Coronavirus,

[키워드] activate anti-IFN-γ anti-TNF-α Author blockade cascades CD4 CD8 cells characteristic co-expressed Coagulation Combination Control damaged demonstrated described determined exhibited expression Fgl2 FH fibrinogen Fluorescence fulminant viral hepatitis functional hepatocellular IFN-γ immunopathological immunopathological damage Immunotherapy in vivo Infection inhibitory receptor initiate injection investigated led to limit liver Liver damage Lymph node lymph nodes mAb Macrophage maintain mechanism mice Mortality mortality rate mRNA multiple organs murine hepatitis virus Necrosis NK cell occurred organ Pathogenesis peripheral tolerance produced promote Protein Quantitative reduced related RT-PCR sensitive Signaling significantly higher spleen T cells tissue tissue damage tissue lesion tissue lesions TNF-α Transcription was determined wild type wild-type
[DOI] 10.1371/journal.ppat.1001347 PMC 바로가기 [Article Type] Research Article

A Decline in p38 MAPK Signaling Underlies Immunosenescence in Caenorhabditis elegans

Caenorhabditis elegans에서 p38 MAPK 신호 전달의 감소는 면역 노화의 기초가 됩니다

Research Article

Published on 2011-05-192022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] addressed age aging amplify Author Bacteria Bacterial Bacterial infection Caenorhabditis Caenorhabditis elegan Caenorhabditis elegans change conserved cycle death Decline declines Defense defined Deterioration elegan examined exhibit Genetic Host host defense human pathogen humans immune function immunosenescence impair implicated increase in Infection innate immune Innate immunity intestinal intestinal tissue involved leads MAPK mice mitogen mitogen-activated protein kinase molecular basis molecular mechanism motion pathogen pathway phenomenon PMK-1 proliferation promote Protein protein kinase Pseudomonas aeruginosa regulate signaling pathway susceptibility tissue damage turn
[DOI] 10.1371/journal.pgen.1002082 PMC 바로가기 [Article Type] Research Article

A Murine Model to Study the Antibacterial Effect of Copper on Infectivity of Salmonella Enterica Serovar Typhimurium

살모넬라 엔테리카 티피무리움 혈청형의 감염성에 대한 구리의 항균 효과를 연구하기 위한 생쥐 모델

Article

Published on 2011-01-242024-08-02
Journal: International Journal of Environmental Research and Public Health [Category] 살모넬라증,

[키워드] copper Infectivity murine model phagocytosis ROS-neutralised Salmonella Typhimurium sub-lethal injury tissue damage
[DOI] 10.3390/ijerph8010021 PMC 바로가기 [Article Type] Article