Characteristics of COVID-19 Clinical Trials in China Based on the Registration Data on ChiCTR and ClinicalTrials.govReview Published on 2020-05-292023-06-16 Journal: Drug design, development and therapy [Category] MERS, SARS, [키워드] Blinding clinical trial COVID-19 interventional Randomized [DOI] 10.2147/DDDT.S254354 PMC 바로가기 [Article Type] Review
Rethinking cancer clinical trials for COVID-19 and beyond Comments & Opinion Published on 2020-05-292022-10-05 Journal: Nature cancer [Category] SARS, 임상, 치료기술, 치료법, [키워드] Cancer clinical trial COVID-19 Rethinking [DOI] 10.1038/s43018-020-0083-x [Article Type] Comments & Opinion
Clinical Implications of Chloroquine and Hydroxychloroquine Ototoxicity for COVID-19 Treatment: A Mini-ReviewCOVID-19 치료에 대한 클로로퀸 및 하이드록시클로로퀸 이독성의 임상적 의미: 미니 리뷰Review Published on 2020-05-292022-09-11 Journal: Frontiers in Public Health [Category] SARS, 치료제, [키워드] auditory Autoimmune diseases Characteristics Chloroquine clinical clinical trial clinical trials COVID-19 COVID-19 infection COVID-19 pandemic damage dose drug dysfunction Effect effective greater hearing loss Hydroxychloroquine hydroxychloroquine treatment Imbalance implication inner ear Intervention lAbel malaria Newborn off-label off-label use ototoxic ototoxicity pregnant women protocol reported sensorineural hearing loss structures suggested survivor tinnitus treated Treatment Trial urgent investigation usual dosage [DOI] 10.3389/fpubh.2020.00252 PMC 바로가기 [Article Type] Review
TRPV4: A Physio and Pathophysiologically Significant Ion ChannelReview Published on 2020-05-282022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] animal model channel clinical trial Consequences disease dysfunction Evidence highlight Human invertebrate Ion pathophysiological physiological Potential Protein receive Significant Structure therapeutic target Transient TRP TRP channels TRPV1 TRPV4 variety vertebrates [DOI] 10.3390/ijms21113837 PMC 바로가기 [Article Type] Review
Thalidomide-Revisited: Are COVID-19 Patients Going to Be the Latest Victims of Yet Another Theoretical Drug-Repurposing?Immunology Published on 2020-05-282022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, [키워드] “cytokine storm” absence airway anti-inflammatory drug Anti-viral clinical trial complementary complications of COVID-19 coronavirus disease COVID-19 COVID-19 patient Cytokine storm drug Drug repurposing effective Effectiveness Efficacy and safety Efficiency Evidence exaggerated inflammatory response FDA approval Health inflammatory complication lack lung lung injuries Lung injury Multiple myeloma occur offer outcome pandemic Patient positive progression pulmonary diseases Registered respiratory complication subsequent thalidomide treated Vaccine victim viral infection [DOI] 10.3389/fimmu.2020.01248 PMC 바로가기 [Article Type] Immunology
Vaccines and Drug Therapeutics to Lock Down Novel Coronavirus Disease 2019 (COVID-19): A Systematic Review of Clinical TrialsInternal Medicine Published on 2020-05-282022-10-31 Journal: Cureus [Category] COVID-19, [키워드] 2019 novel coronavirus Antiviral approved BCG candidate cellular therapy Chinese Chloroquine clinical clinical trial Combination Compound conducted COVID 19 COVID-19 database deaths drug drug combination drug therapeutics effective healthcare ICTRP Infection information lock majority medication novel novel coronavirus disease observational study pandemic Phase I phase III trial registry responsible review sars-cov-2 (severe acute respiratory syndrome coronavirus -2) Stage tested therapeutic agent Therapeutics therapy Treatment treatment choices Trial Vaccine vaccine candidate Vaccines viral infection WHO [DOI] 10.7759/cureus.8342 PMC 바로가기 [Article Type] Internal Medicine
Colchicine’s effects on metabolic and inflammatory molecules in adults with obesity and metabolic syndrome: results from a pilot randomized controlled trial Research Published on 2020-05-272022-10-05 Journal: International journal of obesity (2005) [Category] SARS, 바이오마커, [키워드] addition adjust affected age analyzed Atherosclerosis baseline benefit Benjamini–Hochberg procedure blood sample BMI C-reactive protein cardiometabolic changed circulating clinical trial Colchicine colchicine’ collected Concentration COVID-19 demonstrated double-blind Effect Effects eight endothelial function Factor false discovery rate FDR groups IL-6 IMPROVE Inflammatory innate immune system involved low-density mechanism metabolism multiple testing not different obesity objective outcome oxidized Placebo post-intervention Protein Randomized Randomized controlled trial recent receptor Research Result secreted serum sample significantly significantly increased syndrome was used [DOI] 10.1038/s41366-020-0598-3 [Article Type] Research
Research Progress of Coronavirus Based on Bibliometric AnalysisArticle Published on 2020-05-262022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, SARS, [키워드] accelerate Analysis Bibliometrics China clinical trial contributed coronavirus corresponding vaccine COVID-19 database Developing distribution drug Epidemics Hong Kong hotspot International journal Progress proportion provided Research researchers retrieved rising SARS-CoV-2 Support the United State university Virology was used Web of Science were used [DOI] 10.3390/ijerph17113766 PMC 바로가기 [Article Type] Article
Can Stem Cells Beat COVID-19: Advancing Stem Cells and Extracellular Vesicles Toward Mainstream Medicine for Lung Injuries Associated With SARS-CoV-2 InfectionsBioengineering and Biotechnology Published on 2020-05-262022-10-31 Journal: Frontiers in Bioengineering and Biotechnology [Category] COVID-19, [키워드] Administered Advancing anti-inflammatory agents Anti-viral attenuate Beat Can caused clinical trial clinical utility Combination coronavirus (2019-nCoV) COVID-19 COVID-19 disease curative Cytokine storm disease EVs Exosome extracellular vesicle Extracellular vesicles immunomodulatory IMPROVE Inflammation intravenously investigated lung damage lung injuries mainstream majority mechanism Medicine MSC MSCs outcome Patient people with COVID-19 pharmacological treatments regenerative properties reported risk SARS-CoV-2 SARS-CoV-2 virus secreted STEM stem cell Stem cell therapy survival therapeutic agents therapeutic effect therapeutic potential therapeutic strategy Therapies therapy Treatment treatment for COVID-19 Trial while [DOI] 10.3389/fbioe.2020.00554 PMC 바로가기 [Article Type] Bioengineering and Biotechnology
Reducing the Fatality Rate of COVID-19 by Applying Clinical Insights From Immuno-Oncology and Lung TransplantationPharmacology Published on 2020-05-262022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] 2019-nCoV accelerated acute lung injury acute respiratory distress syndrome Algorithm Applying ARDS Arm cause clinical clinical development clinical trial Combination COVID-19 Cytokine release syndrome effective effective strategy Enrollment Fatality rate identify inflammatory process insight lung lung transplantation multi-organ failure Pneumonia Rate reducing Safe systemic capillary leak Treatment Trial [DOI] 10.3389/fphar.2020.00796 PMC 바로가기 [Article Type] Pharmacology