HPV integration hijacks and multimerizes a cellular enhancer to generate a viral-cellular super-enhancer that drives high viral oncogene expressionHPV 통합은 높은 바이러스 종양 유전자 발현을 유도하는 바이러스 세포 슈퍼 인핸서를 생성하기 위해 세포 인핸서를 가로채고 다량체화합니다.Research Article Published on 2018-01-242022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accumulation amplification amplified BRD4 Cancer cancers cellular cellular DNA chromatin chromosome composed de novo dysregulated element enhancer Epigenetic example expressed expression generate genesis Genetic Genome genomic H3K27ac Host HPV human cancers human papillomavirus Infection integration intergenic region loci locus marker mechanism molecular mutations Next-generation sequencing oncogene oncogenesis papillomavirus positive promote promoted provide random regulatory region responsible sequence super-enhancer transcript Transcription tumors Type unique upstream Viral viral DNA viral genome virus [DOI] 10.1371/journal.pgen.1007179 PMC 바로가기 [Article Type] Research Article
Seroprevalence of hepatitis B surface antigenemia and viral infectivity among liver cancer patients accessing care at a tertiary health facility in Southwest NigeriaArticle Published on 2018-01-012023-06-16 Journal: Journal of immunoassay & immunochemistry [Category] B형 간염, [키워드] Cancer HBV Nigeria Radiotherapy viral infectivity [DOI] 10.1080/15321819.2018.1428992
Therapy for Cancer: Strategy of Combining Anti-Angiogenic and Target TherapiesReview Published on 2017-12-072023-08-30 Journal: Frontiers in Cell and Developmental Biology [Category] E형 간염, [키워드] Angiogenesis Cancer resistance target therapy VEGF [DOI] 10.3389/fcell.2017.00101 PMC 바로가기 [Article Type] Review
Therapeutic induction of high endothelial venules (HEVs) to enhance T-cell infiltration in tumorsEditorial Published on 2017-11-212023-08-29 Journal: Oncotarget [Category] E형 간염, [키워드] Antiangiogenic therapy Cancer high-endothelial venules Immunotherapy lymphotoxin-beta receptor [DOI] 10.18632/oncotarget.22276 PMC 바로가기 [Article Type] Editorial
Tumour virus vaccines: hepatitis B virus and human papillomavirusReview Published on 2017-10-192023-06-18 Journal: Philosophical Transactions of the Royal Society B: [Category] B형 간염, [키워드] Cancer Hepatitis B virus human papillomavirus Prophylactic Vaccine Virus-like particle [DOI] 10.1098/rstb.2016.0268 PMC 바로가기 [Article Type] Review
VDAC1 at the crossroads of cell metabolism, apoptosis and cell stressArticle Published on 2017-10-012023-08-30 Journal: Cell Stress [Category] E형 간염, [키워드] Apoptosis Cancer metabolism Mitochondria VDAC1 [DOI] 10.15698/cst2017.10.104 PMC 바로가기
Rescuing the aberrant sex development of H3K9 demethylase Jmjd1a-deficient mice by modulating H3K9 methylation balanceH3K9 메틸화 균형을 조절하여 H3K9 탈메틸화효소 Jmjd1a 결핍 마우스의 비정상적인 성 발달 구조Research Article Published on 2017-09-262022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activities activity administration approach balance biological function Cancer chromatin complex core histones deficiency demethylase demonstrated Diseases DNA Embryo embryonic enzyme Epigenetic eukaryotes expression Genetic hallmark heterochromatin heterozygous histone histone methylation Histones inhibitor initiate intellectual disability leads locus lysine mammals Methylation methyltransferase mice Modification modulating modulation molecular mechanism mutant Mutation pharmacological phenotype principle proof provide rescued reveal Sex Sex determination Therapeutic strategies therapeutic strategy transcriptional regulation transcriptionally tuning [DOI] 10.1371/journal.pgen.1007034 PMC 바로가기 [Article Type] Research Article
The relative contribution of DNA methylation and genetic variants on protein biomarkers for human diseases인간 질병에 대한 단백질 바이오마커에 대한 DNA 메틸화 및 유전적 변이의 상대적 기여도Research Article Published on 2017-09-152022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] adjusted Affect allele alteration analyses analyzed association Biomarker Biomarkers Cancer cardiovascular disease cardiovascular diseases caused copy CXCL11 CXCL9 disease disease pathogenesis disease status disease-associated Diseases DNA methylation DNA methylation level DNA methylation levels driven by Effect effect size effect sizes effective environmental factor environmental factors Epigenetic Evidence expression expression patterns Factor Genes Genetic Genetic variant genetic variants Genetic variation Genome Genome-wide association study genomic position GWAS Human human disease human diseases IL-12 IL-18 Inflammation loci locus Modification MOST NLRC5 overlapped Pathogenesis performed phenotypic Protein risk smoking SNP SNPs trans unique Variation were measured while [DOI] 10.1371/journal.pgen.1007005 PMC 바로가기 [Article Type] Research Article
Impact of the timing of hepatitis B virus identification and anti-hepatitis B virus therapy initiation on the risk of adverse liver outcomes for patients receiving cancer therapyArticle Published on 2017-09-012023-06-18 Journal: Cancer [Category] B형 간염, Fulltext, [키워드] antiviral therapy Cancer hematologic malignancies hepatitis B Hepatitis B reactivation Hepatitis B screening hepatitis flare liver failure [DOI] 10.1002/cncr.30729 PMC 바로가기
The immune response to secondary necrotic cells이차 괴사 세포에 대한 면역 반응Review Published on 2017-08-312022-08-07 Journal: Apoptosis [Category] Biochemistry, [키워드] Apoptosis apoptotic cell apoptotic cells Autoimmunity Cancer Cancer immunotherapy Cell cell surface cytoplasm DAMPs disease Effect Efferocytosis human physiology immune response immunostimulatory implication Inflammation leakage membrane integrity Modification molecular pattern molecular patterns molecules necroptosis Necrosis necrotic necrotic cell necrotic cells neurodegenerative disorder neurodegenerative disorders Primary necrosis recent regulated released Research Secondary necrosis Secondary necrotic cells the cell [DOI] 10.1007/s10495-017-1413-z PMC 바로가기 [Article Type] Review