Blockade of the C5a–C5aR axis alleviates lung damage in hDPP4 -transgenic mice infected with MERS-CoV
Article
[키워드] accompanied
activated
Activation
acute lung injury
alleviate
antibody treatment
Apoptosis
blockade
C5a
cause
Cell
cells
chemokines
complement
Concentration
contribute
cytokine
dysregulated
elevated
greater
hDPP4
high mortality
highly pathogenic
Host immune response
Inflammatory responses
Intervention
investigated
less
lung
lung damage
lung tissues
manifested
MERS-CoV
MERS-CoV infection
mice
Middle East
observation
outcome
Pathogenesis
promote
receptor
reduced
Respiratory failure
respiratory syndrome coronavirus
secretion
sera
spleen
spleen tissue
T cell
tissue damage
treated
Treatment
triggered
viral infection
viral replication
[DOI] 10.1038/s41426-018-0063-8 PMC 바로가기 [Article Type] Article
[DOI] 10.1038/s41426-018-0063-8 PMC 바로가기 [Article Type] Article