Feasibility of Hepatitis B Vaccination by Microneedle Patch: Cellular and Humoral Immunity Studies in Rhesus MacaquesArticle Published on 2019-11-062023-06-16 Journal: The Journal of Infectious Diseases [Category] B형 간염, Fulltext, [키워드] Adaptive immune response Cellular immune response hepatitis B vaccine Hepatitis B virus microneedle patch rhesus macaques skin vaccination [DOI] 10.1093/infdis/jiz399 PMC 바로가기
Kinetics and Phenotype of the CD4 T Cell Response to Influenza Virus InfectionsOriginal Research Published on 2019-10-022023-06-08 Journal: Frontiers in Immunology [Category] Fulltext, 신종인플루엔자, [키워드] Adaptive immune response CD4 T cells Influenza virus pulmonary immunity T helper subsets [DOI] 10.3389/fimmu.2019.02351 PMC 바로가기 [Article Type] Original Research
The Crohn’s-Like Lymphoid Reaction to Colorectal Cancer-Tertiary Lymphoid Structures With Immunologic and Potentially Therapeutic Relevance in Colorectal CancerArticle Published on 2019-08-222023-08-30 Journal: Frontiers in Immunology [Category] E형 간염, [키워드] Adaptive immune response Colorectal cancer crohn's-like lymphoid reaction ectopic lymphoid structure microsatellite instability (MSI) tertiary lymphoid organs tertiary lymphoid structures (TLS) tumor immunology and microenvironment [DOI] 10.3389/fimmu.2019.01884 PMC 바로가기
Middle East Respiratory Syndrome Coronavirus (MERS-CoV): Infection, Immunological Response, and Vaccine DevelopmentReview Article Published on 2019-04-072022-10-29 Journal: Journal of Immunology Research [Category] Coronavirus, MERS, [키워드] Activation Adaptive immune response adjuvant Antigen approved cellular response Combination contribute country development died Dipeptidyl peptidase-4 DPP4 effective ENhance Factor globe help highlight Host immune response infected patients infections innate immune response key factor knowledge mechanism MERS-CoV Middle East Neutralizing antibodies Pandemics Patient proinflammatory receptor respiratory respiratory syndrome coronavirus response risk Signaling Spike protein Spread therapy Treatment Vaccine Vaccine development virus WHO World Health Organization [DOI] 10.1155/2019/6491738 PMC 바로가기 [Article Type] Review Article
Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus PathogenesisResearch Article Published on 2018-10-092022-10-29 Journal: mBio [Category] Coronavirus, [키워드] absence Activation acute respiratory syndrome Adaptive immune response animal models ARDS Bacterial cascade chemokine chemokines complement contributed controls coronavirus Coronavirus infection Critical cytokine Defense disease distress dysfunction effective exhibited fungal infections high-titer virus Host human infection identify immune Immune cell infiltration Infection Inflammatory cytokine inflammatory monocyte inhibiting intranasal investigated less lung Lung pathology mice mouse-adapted SARS-CoV neutrophil observation outbreak outcome outcomes Pathogenesis pathologic pathology pattern recognition receptor Proinflammatory response Protective reduced regulate relative Replication respiratory Respiratory disease respiratory viruses SARS-CoV SARS-CoV infection sera Severe case Signaling significantly stimulate subsequent syndrome systemic inflammation therapeutic These data Treatment Viral load weight loss [DOI] 10.1128/mBio.01753-18 PMC 바로가기 [Article Type] Research Article
Sex-Dependent Outcome of Hepatitis B and C Viruses Infections: Synergy of Sex Hormones and Immune Responses?Article Published on 2018-10-082023-06-03 Journal: Frontiers in Immunology [Category] B형 간염, Fulltext, [키워드] Adaptive immune response androgens Estrogens HBV HCV innate immune response progesterone Sex [DOI] 10.3389/fimmu.2018.02302 PMC 바로가기
Human β-defensin 2 plays a regulatory role in innate antiviral immunity and is capable of potentiating the induction of antigen-specific immunityResearch Published on 2018-08-082022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] activate Activation Adaptive immune response adaptive immune responses addition adjuvant AMP AMPs antibody Antigen antimicrobial peptide Antiviral antiviral immunity cells chemokine Defense dendritic cells domain effective elicited expressed expression expression level HBD Human Human β-defensin IFN-β IFN-γ IL-1β IL-6 immune Immunity immunization in vitro in vivo innate antiviral immunity innate immune innate immune response Innate immunity investigated leukocytes MERS-CoV mice microorganisms Middle East monocytes/macrophages Natural killer cells Neutralizing antibody response NOD2 PKR promote RBD Regulatory Research Result S RBD Spike protein Subunit vaccine suggested T cells THP-1 TNF-α treat Treatment viruses was used β-defensin [DOI] 10.1186/s12985-018-1035-2 PMC 바로가기 [Article Type] Research
Different Adjuvants Induce Common Innate Pathways That Are Associated with Enhanced Adaptive Responses against a Model Antigen in Humansarticle Published on 2017-08-142024-09-02 Journal: Frontiers in immunology [Category] 대상포진, [키워드] Adaptive immune response AS01 AS03 AS04 innate immune response interferon-γ Vaccine adjuvants [DOI] 10.3389/fimmu.2017.00943 PMC 바로가기 [Article Type] article
From discovery to licensure, the Adjuvant System storyReview Published on 2017-01-162024-09-02 Journal: Human vaccines & immunotherapeutics [Category] 대상포진, [키워드] Adaptive immune response adjuvant Adjuvant system Adjuvanted vaccine innate immune response Vaccine development [DOI] 10.1080/21645515.2016.1225635 PMC 바로가기 [Article Type] Review
Tertiary Lymphoid Structures in Cancers: Prognostic Value, Regulation, and Manipulation for Therapeutic InterventionArticle Published on 2016-10-032023-08-30 Journal: Frontiers in Immunology [Category] E형 간염, [키워드] Adaptive immune response Cancer chemokine Tertiary lymphoid structure tumor microenvironment [DOI] 10.3389/fimmu.2016.00407 PMC 바로가기