Landscapes of SARS-CoV-2-reactive CD8 + T cells: heterogeneity of host immune responses against SARS-CoV-2Research Highlight Published on 2021-04-092022-10-29 Journal: Signal Transduction and Targeted Therapy [Category] COVID-19, MERS, SARS, [키워드] Adaptive immunity CD8 heterogeneity Host immune response Infectious diseases landscape SARS-CoV-2 [DOI] 10.1038/s41392-021-00589-1 PMC 바로가기 [Article Type] Research Highlight
Highly multiplexed 2-dimensional imaging mass cytometry analysis of HBV-infected liverResearch Article Published on 2021-04-082023-06-03 Journal: JCI Insight [Category] B형 간염, Fulltext, [키워드] Adaptive immunity fibrosis hepatology Infectious disease Innate immunity [DOI] 10.1172/jci.insight.146883 PMC 바로가기 [Article Type] Research Article
Vaccine delivery alerts innate immune systems for more immunogenic vaccinationResearch Article Published on 2021-04-082023-06-08 Journal: JCI Insight [Category] Fulltext, 신종인플루엔자, [키워드] Adaptive immunity Vaccines [DOI] 10.1172/jci.insight.144627 PMC 바로가기 [Article Type] Research Article
Involvement of Interleukin-1 Receptor-Associated Kinase 4 and Interferon Regulatory Factor 5 in the Immunopathogenesis of SARS-CoV-2 Infection: Implications for the Treatment of COVID-19Immunology Published on 2021-04-072022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, [키워드] “cytokine storm” activated Adaptive immunity chemokine COVID-19 cytokine Cytokine storm Factor hyperinflammatory state IL-1 inhibitor innate immune response Innate immunity interferon regulatory factor interleukin-1 Involvement irak4 IRF5 kinase Ligand M1 macrophages membranes microbial infection morbidity and mortality NF-κB Pellino-1 plasma potential therapy Proinflammatory cytokine receptor required SARS-CoV-2 signaling pathway synergistic TLR transcription factors [DOI] 10.3389/fimmu.2021.638446 PMC 바로가기 [Article Type] Immunology
Adhatoda Vasica attenuates inflammatory and hypoxic responses in preclinical mouse models: potential for repurposing in COVID-19-like conditionsAdhatoda Vasica는 전임상 마우스 모델에서 염증 및 저산소 반응을 약화: COVID-19 유사 조건에서 용도 변경 가능성Research Published on 2021-04-062022-08-31 Journal: Respiratory Research [Category] MERS, 신약개발, 유전자 메커니즘, 진단, 치료제, [키워드] adaptive Adaptive immunity Adhatoda vasica Airway inflammation Angiogenesis anti-inflammatory effect Anti-inflammatory effects attenuate Bleomycin Blood coagulation cecum Coagulation condition conditions COVID-19 COVID-19 pneumonia downregulation Effect Extract feature fibrosis growth growth factor herbal medicine HIF-1α highlight hyperinflammation hypoxia hypoxic IL-6 IMPROVE Inflammation Inflammatory ligation lung mice molecular Mouse models murine model murine models naïve observation oral administration pathology pathway phenotype Pneumonia pulmonary fibrosis Puncture reduced Replication response Result SARS-CoV2 Sepsis siRNA supplementary material survival rate tested TGF-β1 thrombosis Transcriptome transforming growth factor treated Treatment upregulation Vero Cell Vero cells Viral Viral load [DOI] 10.1186/s12931-021-01698-9 PMC 바로가기 [Article Type] Research
Distinct SARS-CoV-2 antibody reactivity patterns in coronavirus convalescent plasma revealed by a coronavirus antigen microarray코로나바이러스 항원 마이크로어레이로 밝혀진 코로나바이러스 회복기 혈장의 뚜렷한 SARS-CoV-2 항체 반응성 패턴Article Published on 2021-04-062022-09-01 Journal: Scientific Reports [Category] MERS, SARS, 진단, [키워드] acute COVID-19 Adaptive immunity administration analyses Analysis analyzed antibody reactivity Antibody Response Antibody responses Antigen antigens array assays CCP chemiluminescence immunoassay clinical Clinical studies Cluster Clustering analysis collected Computational approaches Concordance convalescent plasma coronavirus COVID-19 case COVID-19 cases COVID-19 convalescent plasma Cutoff disease Donor Emergency use EUA FDA Generalized linear model Hierarchical Hierarchical clustering analysis Humoral immunity identify immunoassay Immunoglobulin IMPROVE Infection intensity MERS Microarray multiplex neutralization Neutralization assay offer plasma plasma sample plasma samples positive Predictive pseudovirus random Random forest reactive reactivity reactivity pattern recombinant proteins reporter Result SARS-1 SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 antigen SARS-CoV-2 antigens SARS-COV-2 infection SARS-CoV2 serum specimen the SARS-CoV-2 therapeutic efficacy threshold thresholds Total total Ig training set Treatment vaccination vaccine immunogenicity Viral viral particle was used with COVID-19 [DOI] 10.1038/s41598-021-87137-7 PMC 바로가기 [Article Type] Article
Antibody responses to endemic coronaviruses modulate COVID-19 convalescent plasma functionalityResearch Article Published on 2021-04-012023-06-14 Journal: The Journal of Clinical Investigation [Category] MERS, SARS, [키워드] Adaptive immunity immunology Infectious disease [DOI] 10.1172/JCI146927 PMC 바로가기 [Article Type] Research Article
Durable SARS-CoV-2 B cell immunity after mild or severe diseaseResearch Article Published on 2021-04-012023-06-15 Journal: The Journal of Clinical Investigation [Category] MERS, SARS, [키워드] Adaptive immunity Beta cells immunology Infectious disease [DOI] 10.1172/JCI145516 PMC 바로가기 [Article Type] Research Article
Longitudinal dynamics of antibody responses in recovered COVID-19 patients회복된 COVID-19 환자에서 항체 반응의 세로 방향 역학Comment Published on 2021-03-312022-09-12 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 진단, [키워드] Adaptive immunity Antibody Response Infectious diseases longitudinal recovered COVID-19 patient Vaccines [DOI] 10.1038/s41392-021-00559-7 PMC 바로가기 [Article Type] Comment
Innate and Adaptive Immunity Alterations in Metabolic Associated Fatty Liver Disease and Its Implication in COVID-19 SeverityImmunology Published on 2021-03-302022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, SARS, [키워드] Adaptive immunity affecting alteration approved Care coronavirus country COVID-19 COVID-19 pandemic disease exacerbated Fatty liver Health immune system Infectious disease Innate innate immune response Innate immunity MAFLD metabolic Mortality NASH obesity pandemic pathology patients potential therapeutic target Prevalence prognostic biomarker progression Research risk SARS-CoV-2 severe COVID-19 Stage susceptible syndrome Treatment type II diabete [DOI] 10.3389/fimmu.2021.651728 PMC 바로가기 [Article Type] Immunology