Systemic pro-inflammatory response identifies patients with cancer with adverse outcomes from SARS-CoV-2 infection: the OnCovid Inflammatory ScoreImmunotherapy Biomarkers Published on 2021-03-222022-10-30 Journal: Journal for immunotherapy of cancer [Category] COVID-19, [키워드] adjusted adverse outcome Analysis can be used Cancer cancer progression changes in Cohort Comorbidity Concordance COVID-19 COVID-19 diagnosis COVID-19 infection domain Eligible patients Europe evaluated exhibited Features identify independent index Inflammation Inflammation mediators Inflammatory investigated malignancy mechanism median men Mortality mortality rate multicenter NLR OIS pathogenic Patient Patients with cancer Predictive pro-inflammatory response prognostic proinflammatory Result reversal Risk category risk stratification SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected patient score severe COVID-19 severity survival survivor susceptible systemic systemic inflammation systemic inflammatory response therapeutic strategy worsened [DOI] 10.1136/jitc-2020-002277 PMC 바로가기 [Article Type] Immunotherapy Biomarkers
Case Report: Severe COVID-19 Pneumonia in a Patient With Relapsed/Refractory Hodgkin’s LymphomaOncology Published on 2021-03-182022-10-31 Journal: Frontiers in Oncology [Category] COVID-19, [키워드] acute respiratory distress adverse outcome Allogeneic allogeneic stem cell ARDS autologous brentuximab Cancer Chemotherapy China coronavirus disease Coronavirus disease 2019 COVID-19 diagnosed Donor donor lymphocyte infusion EBV Effect expected global pandemic graft-versus-host-disease GVHD haematological malignancy Hodgkin’s lymphoma Immunosuppression lymphocyte lymphoma lymphoproliferative disease multiorgan failure Patient reported risk Severe COVID-19 pneumonia Stem cell transplantation suffered syndrome therapy treated viral infection [DOI] 10.3389/fonc.2021.601709 PMC 바로가기 [Article Type] Oncology
A Retrospective Study Assessing the Effect of Diabetes on Mortality in Patients With COVID-19 at a Teaching Hospital in the United KingdomEndocrinology/Diabetes/Metabolism Published on 2021-03-152022-10-31 Journal: Cureus [Category] COVID-19, [키워드] Admission adverse outcome age Assessing Characteristics Clinical characteristics Cohort Coronavirus disease 2019 COVID-19 COVID-19 diagnosis demonstrated diabete diabetes Diabetes Mellitus died Effect evaluated hospital increased mortality Inpatient intensive care Laboratory laboratory-confirmed male mechanical ventilation median age Mortality Multivariate analysis NHS no difference outcome over Patient patients with diabete performed Result Retrospective study Seven significantly increased subgroup analysis Teaching the patient Trust United Kingdom university variable [DOI] 10.7759/cureus.13902 PMC 바로가기 [Article Type] Endocrinology/Diabetes/Metabolism
Time on previous renal replacement therapy is associated with worse outcomes of COVID-19 in a regional cohort of kidney transplant and dialysis patientsObservational Study Published on 2021-03-122022-10-05 Journal: Medicine [Category] SARS, 임상, [키워드] acute respiratory distress adverse outcome affected Analysis ARDS association Asymptomatic chronic Cohort cohort analysis cohorts coronavirus correlated COVID-19 COVID-19-associated ARDS death defined dialysis exhibited Germany Hemodialysis increased risk Interaction kidney transplant Logistic regression analysis majority Mortality multivariate observation outbreak outcome Patient patients proportion recipient remained renal renal replacement therapy retrospective risk factor robust RRT SARS-CoV-2 significantly survival syndrome time with COVID-19 [DOI] 10.1097/MD.0000000000024893 PMC 바로가기 [Article Type] Observational Study
Individualized prediction of COVID-19 adverse outcomes with MLHOArticle Published on 2021-03-052022-10-04 Journal: Scientific Reports [Category] SARS, 바이오마커, [키워드] adverse outcome age Algorithm AUC base Cluster COVID-19 COVID-19 infection COVID-19 pandemic death demographic data demographic variable demographics demonstrated estimate feature Health healthcare Hospitalization ICU ICU admission IMPROVE Infectious disease iterative large cohort machine learning mechanical ventilation medical record Mortality outcome outcomes patients predict Predictive medicine predictor preventive measures ranged representing resource risk Risk factors ROC statistical tested vaccination vector Ventilation [DOI] 10.1038/s41598-021-84781-x PMC 바로가기 [Article Type] Article
Population risk factors for severe disease and mortality in COVID-19: A global systematic review and meta-analysisCOVID-19의 중증 질환 및 사망률에 대한 인구 위험 요인: 글로벌 체계적인 검토 및 메타 분석Research Article Published on 2021-03-042022-08-13 Journal: PLoS ONE [Category] Biology and Life Sciences, COVID-19, MERS, SARS, [키워드] 95% CI active cancer adverse outcome age association Asymptomatic Cancer Characteristics characteristics of patient Comorbidities comparable conducted consolidation COVID-19 COVID-19 infection database disease severity elevated Evidence Factor heterogeneity heterogeneous identify impacted Inclusion increased risk invasive knowledge Male sex measure meta-analyses Meta-analysis methodology Mortality obesity outcome outcomes parameter Patient patients with COVID-19 Population predict profiles reported respiratory rate Result risk risk factor Risk factors risk stratification Sample size Severe case severe cases severe disease Severe obesity SpO2 Study design suggested Symptom systematic review variable while widespread with COVID-19 [DOI] 10.1371/journal.pone.0247461 PMC 바로가기 [Article Type] Research Article
Challenging management of severe chronic disorders in acute pandemic situation: Chronic liver disease under COVID-19 pandemic as the proof-of-principle model to orchestrate the measures in 3PM contextResearch Published on 2021-03-032022-10-31 Journal: The EPMA Journal [Category] COVID-19, [키워드] acute liver failure Acute situation Advanced stages adverse outcome Algorithm approach assigned baseline Cancer Care chronic Chronic disorder chronic liver disease cirrhosis Cirrhosis registry clinical utility condition COVID-19 COVID-19 infection COVID-19 pandemic current death death rates Deterioration disease management Electronic patient records event Expert recommendations female fibrosis green Health policy healthcare Healthcare system Hepatitis highest Impact implementation inherent interval LINE Live transplantation Liver disease lockdown male management measure median age Mortality mortality rates neurological Optimal healthcare modeling orange organized outbreak pandemic Pandemics parameters pathway Patient patient cohorts Patient needs Personalized medicine Personalized treatment algorithms Predictive Predictive preventive personalized medicine (PPPM/3PM) primary care Priority pathways prognostic Red resources responsible risk SARS CoV-2 secondary care sick significantly increased Slovakia Statistics telemedicine consultation Tertiary care the patient treated Treatment [DOI] 10.1007/s13167-021-00231-8 PMC 바로가기 [Article Type] Research
Nicotinic cholinergic system and COVID-19: In silico identification of interactions between α7 nicotinic acetylcholine receptor and the cryptic epitopes of SARS-Co-V and SARS-CoV-2 Spike glycoproteins니코틴성 콜린성 시스템과 코로나19: α7 니코틴성 아세틸콜린 수용체와 SARS-Co-V 및 SARS-CoV-2 스파이크 당단백질의 비밀 에피토프 간의 상호작용에 대한 실리코(in silico) 식별Article Published on 2021-03-012022-09-12 Journal: Food and chemical toxicology : an international jo [Category] SARS, 유전자 메커니즘, 진단, [키워드] adverse outcome agonists anti-SARS-CoV antibody binding site Clinical effect conformations coronavirus COVID-19 CR3022 Cryptic epitope diagnosed dysregulated epitope glycoprotein higher odd homology Hospitalized Hypothesis Interaction less molecular complex Molecular modeling monoclonal antibody nAChRs. pathway protective role protein complex receptor SARS-Co-V SARS-CoV SARS-CoV-2 sequence shown smoker spike spike glycoprotein Spread Support the Spike therapeutic Wuhan [DOI] 10.1016/j.fct.2021.112009 PMC 바로가기 [Article Type] Article
Stigmatization of psychiatric and justice-involved populations during the COVID-19 pandemicResearch article Published on 2021-03-012022-10-05 Journal: Progress in neuro-psychopharmacology & biological [Category] 유전자 메커니즘, [키워드] adverse outcome adverse outcomes Care Characteristics Consequences Correctional population COVID-19 COVID-19 pandemic Critical Forensic psychiatry group groups healthcare imperative media mental health pandemic physical Population Psychiatric psychiatry reflected resource resources Stigma Stigmatization unique Vulnerable populations [DOI] 10.1016/j.pnpbp.2020.110150 [Article Type] Research article
Prevalence of Obesity and Its Impact on Outcome in Patients With COVID-19: A Systematic Review and Meta-AnalysisEndocrinology Published on 2021-02-252022-10-31 Journal: Frontiers in Endocrinology [Category] COVID-19, MERS, [키워드] adverse outcome body mass index COVID-19 database died estimate evaluate Factors Google Scholar higher risk Hospitalization hospitalized patients ICU admission Illness severity Impact IMV increase in intensive care invasive Meta-analysis obese obese patient obesity objective Patient patients with COVID-19 performed polymerase chain presenting Prevalence prevalence rate Prognosis progression real-time reverse transcriptase reported Result review risk factor risk of death SARS-CoV-2 SARS-COV-2 infection statistical significance subject survival systematic review Ventilation [DOI] 10.3389/fendo.2021.598249 PMC 바로가기 [Article Type] Endocrinology