CD26/DPP4 Cell-Surface Expression in Bat Cells Correlates with Bat Cell Susceptibility to Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Infection and Evolution of Persistent InfectionResearch Article Published on 2014-11-192022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] absence antibody Asia assays bat Betacoronavirus betacoronavirus Cell cell line cell lines cellular dose-dependent manner downregulation downstream expression Factors fatal disease functional Host Human identify immunofluorescence Infection inhibited mammals MERS-CoV Middle East persistent plaque receptor reservoir respiratory respiratory syndrome coronavirus susceptibility susceptible syndrome transmission electron microscopy [DOI] 10.1371/journal.pone.0112060 PMC 바로가기 [Article Type] Research Article
Novel Betacoronavirus in Dromedaries of the Middle East, 2013Research Published on 2014-04-012022-10-31 Journal: Emerging Infectious Diseases [Category] Coronavirus, [키워드] Analysis association Betacoronavirus Camel camel coronavirus cleavage site Complete conducted coronavirus DcCoV DcCoVUAE-HKU23 dromedaries Dromedary dromedary camel coronavirus UAE-HKU23 dromedary coronavirus Dubai Fecal sample G+C Genome genomes humans infect Lineage membrane protein MERS-CoV Middle East Middle East respiratory syndrome Coronavirus novel novel Betacoronavirus nucleocapsid protein phylogenetically serum sample Surveillance tested United Arab Emirates virus virus virus transmission viruses zoonoses [DOI] 10.3201/eid2004.131769 PMC 바로가기 [Article Type] Research
Ecology, evolution and classification of bat coronaviruses in the aftermath of SARSArticle Published on 2013-10-312023-05-31 Journal: Antiviral Research [Category] MERS, 조류인플루엔자, [키워드] alphacoronavirus bats Betacoronavirus Coronaviridae taxonomy zoonosis [DOI] 10.1016/j.antiviral.2013.10.013 PMC 바로가기 [Article Type] Article
Role of the Spike Glycoprotein of Human Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in Virus Entry and Syncytia FormationResearch Article Published on 2013-10-032022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] 293T cell activate Affect antibody bats Betacoronavirus blocked cathepsin L cathepsin L-dependent Cell cell type Cl cleave cleaved co-expressed coronavirus coronavirus spike glycoprotein determined elicit endosome Eptesicus experiment Express Extracellular fluids Formation function glycoprotein host cell host protease host range Human immunoblot inhibitor lentivirus maturation membrane fusion MERS MERS-CoV MERS-CoV S protein MHV Middle East murine Neutral Neutralizing antibodies New World non-infectious plasma membrane polyclonal produced producing pseudotype pseudovirion pseudovirus entry reagent receptor released Research respiratory role S protein S2 domain serine protease Spike protein Syncytia syncytia formation the S protein the Spike tissue Treatment triggered trypsin variety VERO E6 cells viral spike virus virus virus entry [DOI] 10.1371/journal.pone.0076469 PMC 바로가기 [Article Type] Research Article
Full-Genome Deep Sequencing and Phylogenetic Analysis of Novel Human BetacoronavirusExpedited Published on 2013-05-012022-10-31 Journal: Emerging Infectious Diseases [Category] Coronavirus, [키워드] Analysis bat coronavirus Betacoronavirus circulating Complication computer-aided design Coronavirus infections country deep disease transmission European events Evolution genome sequence Genome sequencing High-throughput nucleotide sequencing Human human infection infectious Middle East molecular novel novel Betacoronavirus Patient Phylogenetic analysis renal Respiratory tract infections Sequencing specimen sputum Vespertilionidae viral variant virus virus genome viruses zoonoses zoonotic [DOI] 10.3201/eid1905.130057 PMC 바로가기 [Article Type] Expedited
Cross-reactive antibodies in convalescent SARS patients’ sera against the emerging novel human coronavirus EMC (2012) by both immunofluorescent and neutralizing antibody testsArticle Published on 2013-04-102023-06-15 Journal: The Journal of Infection [Category] Fulltext, MERS, [키워드] antibody Betacoronavirus coronavirus cross-reactive EMC HKU1 neutralization OC43 SARS Seroprevalence [DOI] 10.1016/j.jinf.2013.03.015 PMC 바로가기 [Article Type] Article
Immunoreactivity characterisation of the three structural regions of the human coronavirus OC43 nucleocapsid protein by Western blot: Implications for the diagnosis of coronavirus infectionArticle Published on 2012-11-192022-11-01 Journal: Journal of virological methods [Category] Coronavirus, MERS, [키워드] Adults antibody Antigen antigenicity Betacoronavirus Blood blood sample C-terminal domain characterisation Coronavirus infection cross-react demonstrated detected antibody Diagnosis diagnostic different E, Envelope Elderly patient epidemiological evaluated greater HCoV-229E HCoV-OC43 HCoV-OC43, human coronavirus OC43 Human coronavirus human coronavirus OC43 human CoV human serum humans identify immune response immunoreactivity Infection IPTG, β-d-1-thiogalactopyranoside M, matrix N-terminal domain NP, nucleocapsid protein nucleocapsid protein OC43 strain occur offer patients polyclonal polyclonal antibody previous study produced Protein purified rabbit polyclonal antibody reactivity Region reported respiratory infection RNP, ribonucleoprotein S, spike SARS-CoV serum serum sample specificity SPR, surface plasmon resonance Strong tested Variability virus infection [DOI] 10.1016/j.jviromet.2012.11.009 PMC 바로가기 [Article Type] Article
Human Coronaviruses: Insights into Environmental Resistance and Its Influence on the Development of New Antiseptic StrategiesReview Published on 2012-11-122022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] acute respiratory syndrome aluminum antiseptic antiseptics-disinfectants Antiviral treatment approach Betacoronavirus biological fluids bronchitis children common cold Coronaviridae family coronavirus coronavirus described development different Efficacy emerging disease environmental condition environmental survival evaluate found HCoV 229E high risk HKU1 hospital Human human coronavirus human coronaviruses humans immunosuppressed patients Infection infections infective influence insight involved knowledge lack led to management mean methodology Neonates New NL63 nosocomial OC43 outbreak pathogen pathogenicity Pneumonia Prevent resistance respiratory diseases responsible RNA virus SARS-CoV specific treatment specificity Spread Strategy Support surgical temperature the Coronaviridae upper respiratory tract viral infections viruses [DOI] 10.3390/v4113044 PMC 바로가기 [Article Type] Review
Profiling of Substrate Specificities of 3C-Like Proteases from Group 1, 2a, 2b, and 3 CoronavirusesResearch Article Published on 2011-11-022022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] 3CL pro acute respiratory syndrome Betacoronavirus cleaved coronavirus correlated CoV CoVs different finding Gln group human CoV hydrophobic residue hydrophobicity IBV Infection Infectious Bronchitis Virus inhibitor NL63 OC43 polyprotein Profiling protease Proteases protein sequences Proteolytic processing residue residues SARS-CoV secondary structure sequence similarity Specificities specificity structural property Substitution substrate variant viral replication Volume [DOI] 10.1371/journal.pone.0027228 PMC 바로가기 [Article Type] Research Article