A decade of antiretroviral therapy in Uganda: what are the emerging causes of death?Research Article Published on 2019-01-212024-09-02 Journal: BMC Infectious Diseases [Category] 대상포진, [키워드] AIDS Antiretroviral therapy causes death HIV Mortality [DOI] 10.1186/s12879-019-3724-x PMC 바로가기 [Article Type] Research Article
Human genetic variation in GLS2 is associated with development of complicated Staphylococcus aureus bacteremiaGLS2의 인간 유전적 변이는 복잡한 황색 포도구균 균혈증의 발병과 관련이 있습니다Research Article Published on 2018-10-052022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activate age allele Analysis association Bacteremia Bacteria Bacterial Blood cells bloodstream Bonferroni correction candidate gene capture cause causes Cell coding variant complex Complication Control correlated CRISPR CRISPR-Cas9 cumulative cumulative effect death eight ENCODE evaluated examined exhibited Exome expression expression level Factor Frequency gene-based analysis gene-expression Genetic genetic factors genetic risk factor Genetic variant genetic variants Genetic variation Genome GLS2 Glutamine growth healthy controls Hospitalization Host Human Human genome immune response individual Infection infections Interaction key factor leukocyte leukocyte activation Logistic regression analysis Macrophage macrophage cells metabolism Microarray missense variant nitric oxide plasma concentration Protein regulate Regulatory Replication risk S . aureus sequence Sequencing Sex significantly significantly lower Staphylococcus aureus susceptible the strongest These cells Transcription variant variants Variation variations WES White blood cell White blood cells wild-type cells [DOI] 10.1371/journal.pgen.1007667 PMC 바로가기 [Article Type] Research Article
Causes and Timing of Mortality and Morbidity Among Late Presenters Starting Antiretroviral Therapy in the REALITY TrialREALITY 임상시험에서 항레트로바이러스 치료를 시작한 후기 발표자의 사망률과 이환율의 원인과 시기Advanced HIV Disease Published on 2018-04-012022-09-06 Journal: Clinical Infectious Diseases: An Official Publicat [Category] Communicable Disease, [키워드] advanced disease Africa albendazole anti-infection Antiretroviral therapy ART Azithromycin Bacterial infection blinded cause causes CD4 clinical cotrimoxazole cryptococcosis death declined died enhanced event events fluconazole highlight HIV incidence Infection infections isoniazid median morbidity Mortality occurred participant Participants pre-ART CD4 presenter Prophylaxis randomized trial REALITY reduced Registration Result severe immunosuppression starting sub-Saharan Africa Tuberculosis unknown causes [DOI] 10.1093/cid/cix1141 PMC 바로가기 [Article Type] Advanced HIV Disease
Shared genetic regulatory networks for cardiovascular disease and type 2 diabetes in multiple populations of diverse ethnicities in the United States미국 내 다양한 민족의 여러 인구에서 심혈관 질환 및 제2형 당뇨병에 대한 공유 유전 조절 네트워크Research Article Published on 2017-09-282022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activity African Americans alterations American Americans Amino acid amino acid metabolism amino acids biological processe biological processes branched-chain amino acids cardiovascular cardiovascular disease cardiovascular diseases cause causes CAV1 Cell culture co-expression Cohort commonality complex disease connection Critical CVD data-driven death diabetes disease Diseases Diversity driven by driver ENCODE Epidemics eQTLs expression expression quantitative trait loci Extracellular matrix finding FIVE functional Functional genomics gene knockout gene network gene networks Genetic genetic risk Genome-wide association study Glucose graphical models GWAS GWAS hit help Hispanic HMGCR human population human populations hybrid identify IGF1 immune response in vitro in vivo information Integrative analysis knockdown lipids loci mechanism metabolism molecular molecular network mouse Mouse models multidimensional multiple tissues network models neuronal offer overlapping Panel Pathogenesis pathogenic pathogenic processe pathway Pathways PCOLCE Population populations Quantitative Regulatory regulatory network Risk factors shared pathway shared pathways siRNA Strains Support T2D the United State therapeutic therapeutic target tissues type 2 diabete type 2 diabetes [DOI] 10.1371/journal.pgen.1007040 PMC 바로가기 [Article Type] Research Article
Fifty Years of Research in ARDS. Cell-based Therapy for Acute Respiratory Distress Syndrome. Biology and Potential Therapeutic ValueReview Published on 2017-08-012022-10-06 Journal: American Journal of Respiratory and Critical Care [Category] 진단, [키워드] acute lung injury acute respiratory distress adipose alveolar epithelium alveolar fluid clearance antiinflammatory antimicrobial effect ARDS assays Biology Bone marrow causes Cell clinical trial Clinical use conditioned media Effect Efficacy Endothelium ENhance Factor Factors heterogeneous Hyperinflammatory lung Lung injury Mesenchymal stromal cells Microvesicles MSC MSCs paracrine patients with ARDS phagocytosis phase phase 1 trial Potential preclinical studies Pulmonary edema respiratory Serious Adverse Events Support syndrome therapeutic therapeutic potential therapy tissue transfer umbilical up-regulating value Year [DOI] 10.1164/rccm.201701-0107CP PMC 바로가기 [Article Type] Review
Periodontal Ehlers-Danlos Syndrome Is Caused by Mutations in C1R and C1S , which Encode Subcomponents C1r and C1s of Complement치주 엘러스-단로스 증후군은 보체의 하위 구성요소 C1r 및 C1을 인코딩하는 C1R 및 C1S의 돌연변이로 인해 발생합니다.Article Published on 2016-11-032022-08-07 Journal: American Journal of Human Genetics [Category] 유전자 메커니즘, [키워드] affected attached gingiva autosomal-dominant disorder bruising C1q C1r candidate gene causes characterized childhood classical clinical Clinical features Complement pathway connection connective tissue defined early-onset periodontitis Ehlers-Danlos syndrome Endoplasmic reticulum feature Frame Genetic Gingiva heterotetramer heterozygous homeostasis hyperpigmentation identify include independent individual Inflammatory insertion/deletion International joint joint hypermobility lack locus loss of teeth mapped Mild Missense Musculoskeletal Mutation open periodontal Periodontitis physiological Premature pretibial hyperpigmentation Protein recruited skin subunit subunit interface subunits Symptoms teeth variant Vascular vascular fragility [DOI] 10.1016/j.ajhg.2016.08.019 PMC 바로가기 [Article Type] Article
Prevalence of anaemia among Quranic school (Khalawi) students (Heiran)in Wad El Magboul village, rural Rufaa, Gezira State, Central Sudan: a cross sectional study수단 중앙부 게지라 주 루파의 와드 엘 마그불 마을에서 꾸란 학교(칼라위) 학생들(헤이란) 사이의 빈혈 유병률: 단면 연구Research Published on 2016-07-152024-08-12 Journal: The Pan African Medical Journal [Category] 말라리아, [키워드] Anemia among childen causes iron deficiency anemia schools Khalwa students traditional Quranic [DOI] 10.11604/pamj.2016.24.244.8355 PMC 바로가기 [Article Type] Research
Molecular Evidence for the Inverse Comorbidity between Central Nervous System Disorders and Cancers Detected by Transcriptomic Meta-analyses전사체 메타 분석에 의해 발견된 중추신경계 장애와 암 사이의 역병환에 대한 분자적 증거Research Article Published on 2014-02-202022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] (Alzheimer's disease Alzheimer's disease Analysis Author biological processe biological processes cancers Candidates causes CENTRAL CNS CNS disorder Colorectal Comorbidity complex disorders conditions conducted contribute decrease Degradation deregulated deregulation described disease disorder disorders downregulated downregulation driven by Drug repurposing drug treatment drug treatments epidemiological Evidence expected expression Factors Gene Genetic genetic factors Hypothesis incidence inverse lung mechanism Meta-analysis molecular nervous observé opposite overlap Parkinson's Disease pathway Pathways Patient PIN1 Probability progression promote Prostate protective effect Protein related risk Schizophrenia System tested transcriptomic Treatment understanding upregulated upregulation Wnt [DOI] 10.1371/journal.pgen.1004173 PMC 바로가기 [Article Type] Research Article