A five-day course of ivermectin for the treatment of COVID-19 may reduce the duration of illnessRandomized Controlled Trial Published on 2021-02-012022-10-05 Journal: International Journal of Infectious Diseases [Category] SARS, 임상, 치료법, [키워드] acute respiratory syndrome anti-parasitic assigned Bangladesh clearance clinical Combination comparable conducted control group coronavirus cough Course COVID-19 determine double-blind doxycycline drug duration of illness effective event Fever food hospitalized patient in vitro inhibit Ivermectin ivermectin treatment Mild Patient Placebo placebo-controlled trial preliminary findings Randomized recorded reduce Replication Safe SARS-CoV-2 SARS-CoV-2 patients single dose sore throat Symptom the placebo group three groups Treatment Trial viral clearance [DOI] 10.1016/j.ijid.2020.11.191 PMC 바로가기 [Article Type] Randomized Controlled Trial
Usefulness of Plasma SARS-CoV-2 RNA Quantification by Droplet-based Digital PCR to Monitor Treatment Against COVID-19 in a B-cell Lymphoma PatientB 세포 림프종 환자에서 COVID-19에 대한 치료를 모니터링하기 위한 액적 기반 디지털 PCR에 의한 혈장 SARS-CoV-2 RNA 정량화의 유용성Case Reports Published on 2021-02-012022-09-12 Journal: Stem cell reviews and reports [Category] MERS, 진단, [키워드] absence Against anti-CD20 anti-IL6 autologous B-cell B-cell lymphoma Biomarker Cell clearance Clinical improvement complete recovery convalescent COVID-19 COVID-19 patients COVID19 Deterioration Digital digital PCR Efficacy eligible expected inflammatory markers monoclonal antibody Patient PCR plasma quantified receptor SARS-CoV-2 SARS-CoV-2 RNA slight increase subsequent suffered therapy tocilizumab therapy treated Treatment [DOI] 10.1007/s12015-020-10107-5 PMC 바로가기 [Article Type] Case Reports
Optimization of hydroxychloroquine dosing scheme based on COVID-19 patients’ characteristics: a review of the literature and simulations코로나19 환자 특성에 따른 하이드록시클로로퀸 투여 계획 최적화: 문헌 검토 및 시뮬레이션Review Published on 2021-02-012022-09-11 Journal: Xenobiotica; the fate of foreign compounds in biol [Category] 치료제, [키워드] adverse effects applied benefit clearance Clinical practice Clinical studies Concentration COVID-19 COVID-19 outbreak COVID-19 patient COVID-19 treatment Diagnosis dose effective Efficacy Efficacy and safety Evidence followed by HCQ Hydroxychloroquine impairment initial knowledge Loading dose modeling and simulation Moderate COVID-19 offer optimization Patient patients performed pharmacokinetic pharmacokinetics Population Precision precision dosing. provide retrieved Safe Symptom tested therapeutic option Treatment variety Viral Viral load was performed was selected [DOI] 10.1080/00498254.2020.1824301 PMC 바로가기 [Article Type] Review
Host sphingolipids: Perspective immune adjuvant for controlling SARS-CoV-2 infection for managing COVID-19 disease숙주 스핑고지질: COVID-19 질병 관리를 위한 SARS-CoV-2 감염 제어를 위한 관점 면역 보조제Review Published on 2021-02-012022-09-11 Journal: Prostaglandins & other lipid mediators [Category] SARS, 신약개발, 치료제, [키워드] Activation Antigen presentation Antiviral approach autophagy Bacterial infections ceramide clearance COVID 19 COVID-19 cases COVID-19 disease COVID-19 infection COVID-19 patients derivative effector immune response enzyme II epithelial cell epithelial cells expected Features fibrosis fingolimod FTY720 Host host-pathogen interactions human diseases hyper-inflammatory response Hyper-inflammatory responses IL-6 immune Immune adjuvants immune responses immunosuppressive Infection involved Lipid Lyase M1/M2 macrophages macrophages membrane-bound modulate Pathogenesis pathological outcomes pathological response phosphate promote receptor Replication respiratory SARS-CoV-2 SARS-COV-2 infection Signaling sphingolipid sphingolipids sphingosine-1-phosphate symptomatic T cell T cell response Th1 Th1 effector response. [DOI] 10.1016/j.prostaglandins.2020.106504 PMC 바로가기 [Article Type] Review
Depicting SARS-CoV-2 faecal viral activity in association with gut microbiota composition in patients with COVID-19COVID-19 환자의 장내 미생물 구성과 관련된 SARS-CoV-2 대변 바이러스 활동 묘사Observational Study Published on 2021-02-012022-09-11 Journal: Gut [Category] SARS, 임상, 치료기술, [키워드] absence active viral infection acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alteration Amino acid amino acid biosynthesis association Bacteria bacterial specy Bacteroide carbohydrate clearance clearance of SARS-CoV-2 coronavirus Coverage de novo density diagnostic diagnostic virology disease course enrichment Evidence faece Faeces fatty Fatty acid functional functional capacity GI Tract Glycolysis Gut gut inflammation gut microbiota gut microbiota composition hospitalised patient Infection Infectious disease investigated manifestation Manifestations metabolism metagenome metagenomic sequencing Microbiome microbiome composition microbiota nucleotide Opportunistic Pathogens Pathogens Patient patients with COVID-19 performed pilot study producing provide quantified respiratory respiratory infection Respiratory samples RNA SARS-CoV-2 SARS-CoV-2 genome Sequencing sequencing coverage Seven severe acute respiratory syndrome Coronavirus signature Stool Streptococcus the SARS-CoV-2 genome transcriptional activity Viral viral extraction viral infection Viral RNA virus with COVID-19 [DOI] 10.1136/gutjnl-2020-322294 PMC 바로가기 [Article Type] Observational Study
Mucociliary Respiratory Epithelium Integrity in Molecular Defense and Susceptibility to Pulmonary Viral InfectionsReview Published on 2021-01-292022-10-28 Journal: Biology [Category] COVID-19, [키워드] acute respiratory disease acute respiratory syndrome airways arising Bearing Cell cellular and molecular changes in chronic respiratory disease ciliary ciliated ciliated cells clearance coronavirus Coronavirus disease-19 Coronavirus-2 COVID-19 Defense develop directional disrupt driven by dysfunction elicit epithelial epithelium Genetic goblet cells Health healthy help host infection Human implication include individual Infection integrity Interaction involved lethal infection lung lung cilia maintain management MCC mechanism microbial infection microbial infections molecular molecular component Mucociliary clearance Mucus nasopharynx novel virus pandemic pathogen pathophysiology Patient predicted Protein pulmonary Pulmonary function regulate respiratory Respiratory disease respiratory diseases respiratory epithelium Respiratory system respiratory tract SARS-CoV-2 viral simple Surveillance susceptible transcriptional [DOI] 10.3390/biology10020095 PMC 바로가기 [Article Type] Review
Natural killer cells associated with SARS-CoV-2 viral RNA shedding, antibody response and mortality in COVID-19 patientsLetter to the Editor Published on 2021-01-272022-10-31 Journal: Experimental Hematology & Oncology [Category] COVID-19, [키워드] acute respiratory syndrome Admission Antibody Response B cell basophil caused cell count cells clearance Cohort coronavirus Coronavirus disease 2019 correlated correlation COVID-19 COVID-19 patient COVID-19 patients criteria CRP discharge first positive IgG antibody IgM/ IgG antibody IgM/IgG IL-6 Infection Inflammation innate immune cell Killer cell Lymphocyte count Lymphocyte subset Lymphocytes lymphocytopenia Mortality Nasopharyngeal swab natural natural killer cell Neutrophils NK cell non-severe group oropharyngeal swabs parameter Patient Peripheral blood platelets counts respiratory symptom RNA viral shedding SARS-CoV-2 SARS-CoV-2 viral RNA serum cytokine severe group significant difference significantly significantly lower specimens survival rate T cells therapy Treatment upper respiratory tract viral disease Viral RNA viral shedding White blood cells [DOI] 10.1186/s40164-021-00199-1 PMC 바로가기 [Article Type] Letter to the Editor
Single-cell RNA sequencing reveals SARS-CoV-2 infection dynamics in lungs of African green monkeys단일 세포 RNA 시퀀싱은 아프리카 녹색 원숭이의 폐에서 SARS-CoV-2 감염 역학을 보여줍니다Research Article Published on 2021-01-272022-09-10 Journal: Science Translational Medicine [Category] 유전자 메커니즘, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 African green monkey African green monkeys Alveolar macrophages Analysis animal model animal models animals best Cell cellular debris clearance contribute coronavirus coronavirus disease Coronavirus disease 2019 Course COVID-19 dataset degrade determine Factor genomic RNA green monkeys Host Host immune response host response host responses identify immune cell population immune cell populations immune responses in vivo inactivated Indicator infected cell infected cells Infection infiltrating Inflammatory response information inoculated knowledge lung Lungs Lymph node Macrophage macrophages mediastinal lymph nodes Mild mild to moderate moderate monocyte Monocyte-derived macrophages occur Pathogenesis phagocytosis pneumocyte Pneumocytes provide recruited replicate Replication respiratory respiratory tract responsible reveal RNA RNA sequencing SARS-CoV-2 SARS-COV-2 infection Sequencing sequencing data severe acute respiratory syndrome Coronavirus Single-cell RNA sequencing switching therapeutic targets valuable resource Viral viral genome viral replication virus virus replication while [DOI] 10.1126/scitranslmed.abe8146 PMC 바로가기 [Article Type] Research Article
Review of Medical Therapies for the Management of Pulmonary EmbolismReview Published on 2021-01-262022-10-30 Journal: Medicina [Category] Coronavirus, [키워드] administration antagonist antagonists Anticoagulant Anticoagulant treatment Anticoagulants anticoagulation clearance COVID-19 direct oral anticoagulants (DOAC) effective Embolism employment Evidence Evolution heparin Interaction limitations liver malignancy management medication parameters Patient pharmacological management populations provided pulmonary pulmonary embolism (PE) renal Research review Safe therapeutic option therapy Toxicity venous thromboembolism (VTE) [DOI] 10.3390/medicina57020110 PMC 바로가기 [Article Type] Review
Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages기관지폐포 세척액의 선천적 및 적응 면역 단일 세포 프로파일링을 통해 심각한 COVID-19와 경증 구별Article Published on 2021-01-212022-09-12 Journal: Cell Research [Category] 유전자 메커니즘, 임상, 진단, 치료기술, [키워드] adaptive Alveolar macrophages Anti-inflammatory BAL bioinformatics Bronchoalveolar lavage build CD4 CD8 Cell change Characteristics characterized clearance contribute COVID-19 Critical Evidence expressing fibrosis functions Gene Expression Genome-wide analysis of gene expression host immune system Hyperinflammatory immune immunopathology in viral Innate immunity involved lung Lung epithelial cells Macrophage marker Mild monocyte naïve neutrophil Non-COVID-19 Patient Pneumonia proportion reveal single-cell Stress T-cell Trajectories trajectory undergo vice [DOI] 10.1038/s41422-020-00455-9 PMC 바로가기 [Article Type] Article